Food & Function,
Год журнала:
2023,
Номер
14(12), С. 5606 - 5619
Опубликована: Янв. 1, 2023
Ginseng,
when
used
as
a
food
and
nutritional
supplement,
has
the
ability
to
regulate
human
immunity.
Here,
potential
anti-hepatic
fibrosis
effect
of
ginsenoside
Rd
(Rd),
one
protopanaxadiol
types
ginsenoside,
was
investigated.
We
established
hepatic
model
using
intraperitoneal
injection
thioacetamide
(TAA)
for
five
weeks
in
mice.
In
addition,
an
vitro
by
TGF-β
activate
stellate
cells
(HSCs),
treated
with
estrogen-related
receptor
α
(ERRα)
inhibitor
(XCT-790).
The
ERRα
knockdown
(shRNA-ERRα)
primary
mouse
hepatocytes
establish
hepatocyte
injury
TGF-β,
they
were
then
incubated
Rd.
significantly
alleviated
histopathological
changes,
reduced
serum
alanine
aminotransferase
(ALT)
aspartate
(AST)
levels.
could
upregulate
downregulate
markers
livers
TAA-induced
mice,
inhibited
purinergic
ligand-gated
ion
channel
7
(P2X7r)-mediated
NLRP3
inflammasome
activation,
consequently
reversing
liver
inflammatory
response.
increased
expression
suppressed
extracellular
matrix
(ECM)
HSCs
or
hepatocytes.
decreased
P2X7r-mediated
response,
including
production
IL-1β,
IL-23
activated
ameliorate
damage
further
inhibit
entry
IL-1β
IL-18
into
matrix.
reaction
regulating
ERRα-P2X7r
signaling
pathway
while
suppressing
fibrogenesis,
which
suggests
that
can
serve
novel
dietary
supplement
approach
combat
fibrosis.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(5), С. 4772 - 4772
Опубликована: Март 1, 2023
Depression
is
a
mental
health
disorder
that
develops
as
result
of
complex
psycho-neuro-immuno-endocrinological
disturbances.
This
disease
presents
with
mood
disturbances,
persistent
sadness,
loss
interest
and
impaired
cognition,
which
causes
distress
to
the
patient
significantly
affects
ability
function
have
satisfying
family,
social
professional
life.
requires
comprehensive
management,
including
pharmacological
treatment.
Because
pharmacotherapy
depression
long-term
process
associated
risk
numerous
adverse
drug
effects,
much
attention
paid
alternative
therapy
methods,
phytopharmacotherapy,
especially
in
treating
mild
or
moderate
depression.
Preclinical
studies
previous
clinical
confirm
antidepressant
activity
active
compounds
plants,
such
St.
John’s
wort,
saffron
crocus,
lemon
balm
lavender,
less
known
European
ethnopharmacology,
roseroot,
ginkgo,
Korean
ginseng,
borage,
brahmi,
mimosa
tree
magnolia
bark.
The
these
plants
exert
antidepressive
effects
similar
mechanisms
those
found
synthetic
antidepressants.
description
phytopharmacodynamics
includes
inhibiting
monoamine
reuptake
oxidase
complex,
agonistic
antagonistic
on
multiple
central
nervous
system
(CNS)
receptors.
Moreover,
it
noteworthy
anti-inflammatory
effect
also
important
mentioned
above
light
hypothesis
immunological
disorders
CNS
are
significant
pathogenetic
factor
narrative
review
results
from
traditional,
non-systematic
literature
review.
It
briefly
discusses
pathophysiology,
symptomatology
treatment
depression,
particular
focus
role
phytopharmacology
its
provides
action
revealed
experimental
ingredients
isolated
herbal
antidepressants
selected
confirming
their
effectiveness.
Nanoscale,
Год журнала:
2023,
Номер
15(12), С. 5798 - 5808
Опубликована: Янв. 1, 2023
Ginseng-derived
extracellular
nanovesicles
effectively
blocked
bone
loss
both
in
vitro
and
vivo
by
inhibiting
osteoclast
differentiation
through
RANKL-induced
IκBα,
JNK,
ERK
activation.
Frontiers in Pharmacology,
Год журнала:
2021,
Номер
12
Опубликована: Март 4, 2021
Depressive
disorder
is
a
common
mental
characterized
by
depressed
mood
and
loss
of
interest
or
pleasure.
As
the
Herbal
medicines
are
mainly
used
as
complementary
alternative
therapy
for
depression.
This
study
aimed
at
exploring
antidepressant
activity
Huang-lian
Jie-du
Decoction
(HLJDD),
evaluating
active
components
potential
depression-associated
targets.
HLJDD
was
administered
on
chronic
unpredictable
mild
stress-induced
(CUMS)
depressive
mice.
Behavior
evaluation
performed
through
force
swimming
test
(FST),
novelty-suppressed
feeding
(NSF),
open
field
(OFT).
Active
HLJDD,
targets,
metabolic
pathways
involved
in
depression
were
explored
systemic
biology-based
network
pharmacology
assay,
molecular
docking
metabonomics.
FST
assay
showed
that
CUMS
mice
with
had
significantly
shorter
immobility
time
compared
control
Further,
alleviated
latency
NSFand
increased
moving
distance
duration
OFT.
In
following
thirty-eight
compounds
identified
based
drug-like
characteristics,
pharmacokinetics
pharmacodynamics
profiles.
Moreover,
forty-eight
targets
ten
biochemical
uncovered
GRIN2B,
DRD,
PRKCA,
HTR,
MAOA,
SLC6A4,
GRIN2A,
CACNA1A
implicated
inhibition
symptoms
modulating
tryptophan
metabolism,
serotonergic
dopaminergic
synaptic
activities,
cAMP
signaling
pathway,
calcium
pathway.
Further
pharmacology-based
analysis
correlation
between
metabolism.
A
total
thirty-seven
compounds,
seventy-six
sixteen
These
findings
show
acts
such
INS,
MAO,
CAT,
FoxO,
PI3K/Akt,
calcium,
HIF-1,
mTOR
pathways,
modulates
serotoninergic
functions.
addition,
metabonomics
metabolism
primary
target
The
exhibited
effects.
SLC6A4
MAOA
modulated
berberine,
baicalein,
tetrahydroberberine,
candicine
may
be
main
HLJDD.
Nutrition,
Год журнала:
2023,
Номер
115, С. 112143 - 112143
Опубликована: Июнь 28, 2023
In
recent
years,
there
has
been
a
significant
increase
in
depression,
which
is
related
to,
among
other
things,
the
COVID-19
pandemic.
Depression
can
be
fatal
if
not
treated
or
inappropriately.
leading
cause
of
suicide
attempts.
The
disease
multifactorial,
and
pharmacotherapy
often
fails
to
bring
satisfactory
results.
Therefore,
increasingly
more
importance
attached
natural
healing
substances
nutrients
food,
significantly
affect
therapy
process
prevention
depressive
disorders.
A
proper
diet
vital
preventing
depression
valuable
addition
psychological
pharmacologic
treatment.
An
inadequate
may
reduce
effectiveness
antidepressants
their
side
effects,
life-threatening
symptoms.
This
study
aimed
review
literature
on
pathogenesis
development
treatment
with
particular
emphasis
dietary
supplements
role
nutrition
Pharmaceuticals,
Год журнала:
2024,
Номер
17(4), С. 512 - 512
Опубликована: Апрель 16, 2024
The
incidence
of
depression
has
been
steadily
rising
in
recent
years,
making
it
one
the
most
prevalent
mental
illnesses.
As
pursuit
novel
antidepressant
drugs
captivates
pharmaceutical
field,
therapeutic
efficacy
Traditional
Chinese
Medicine
(TCM)
widely
explored.
Chaihu
(
Planta Medica,
Год журнала:
2021,
Номер
87(09), С. 656 - 685
Опубликована: Янв. 12, 2021
Medicinal
plants
and
their
extracts
are
natural
remedies
with
enormous
potential
for
treating
various
diseases,
including
depression
anxiety.
In
the
case
of
depression,
hundreds
have
traditionally
been
used
in
folk
medicine
generations.
Different
plant
products
analyzed
as
antidepressant
agents
validated
models
to
test
antidepressant-like
effects
animals,
although
other
complementary
studies
also
employed.
Most
these
focus
on
possible
mediators
implicated
effects,
dopamine,
serotonin,
noradrenaline
being
principal
neurotransmitters
implicated,
both
through
interference
receptors
metabolism
by
monoamino
oxidases,
well
neuro-endocrine
neuroprotective
effects.
There
approximately
650
reports
medicinal
PubMed;
155
them
compiled
this
review,
a
relevant
group
yielding
positive
results.
Saffron
turmeric
most
species
studied
preclinical
clinical
studies;
St.
John's
wort
or
kava
tested
extensively.
To
best
our
knowledge,
no
review
date
has
provided
comprehensive
understanding
biomolecular
mechanisms
action
herbs
whether
could
real
benefits.
The
purpose
narrative
is
provide
an
update
regarding
from
year
2000
present
examine
therapeutic
order
contribute
development
new
methods
alleviate
tremendous
burden
that
causes
worldwide.
Nutrients,
Год журнала:
2022,
Номер
14(16), С. 3270 - 3270
Опубликована: Авг. 10, 2022
L-tryptophan
(Trp)
contributes
to
regulating
bilateral
communication
of
the
gut-brain
axis.
It
undergoes
three
major
metabolic
pathways,
which
lead
formation
kynurenine,
serotonin
(5-HT),
and
indole
derivatives
(under
control
microbiota).
Metabolites
from
principal
Trp
pathway,
kynurenic
acid
quinolinic
acid,
exhibit
neuroprotective
activity,
while
picolinic
exhibits
antioxidant
5-HT
modulates
appetite,
sleep
cycle,
pain.
Abnormality
in
plays
crucial
roles
diseases,
including
depression,
colitis,
ulcer,
gut
microbiota-related
dysfunctions.
To
address
these
use
natural
products
could
be
a
favorable
alternative
because
they
are
rich
source
compounds
that
can
modulate
activity
combat
various
diseases
through
modulating
different
signaling
microbiota,
kynurenine
pathway.
Alterations
cascade
pathways
via
phytochemicals
may
help
us
explore
deep
relationships
axis
study
neuroprotection.
This
review
highlights
their
metabolites
targeting
diseases.
Additionally,
role
regulation
gastroprotective
activities
is
discussed.
compiles
literature
on
novel,
potent
agents
action
mechanisms
proposes
prospective
future
studies
identify
more
pharmaceuticals
based
Trp.
