Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Май 2, 2024
Objective
This
research
aims
to
investigate
putative
mechanisms
between
glymphatic
activity
and
cognition
in
mild
cognitive
impairment
(MCI)
analyzes
whether
the
relationship
reserve
(CR)
was
mediated
by
activity.
Methods
54
MCI
patients
31
NCs
were
enrolled
evaluate
bilateral
diffusivity
along
perivascular
spaces
acquire
an
index
for
space
(ALPS-index)
on
diffusion
tensor
imaging
(DTI).
The
year
of
education
used
as
a
proxy
CR.
ALPS-index
compared
two
groups
correlation
analyses
among
ALPS-index,
function,
CR
conducted.
Mediation
applied
correlations
CR,
cognition.
Results
group
had
significantly
lower
right
whole
brain
but
higher
y-axis
projection
fiber
area
(Dyproj)
than
NCs.
In
group,
left
Dyproj
negatively
related
test
scores
positively
correlated
with
analysis
demonstrated
that
partially
function.
Conclusion
exhibited
decreased
has
protective
effect
against
decline
MCI,
this
may
be
changes
Magnetic Resonance in Medical Sciences,
Год журнала:
2024,
Номер
23(3), С. 268 - 290
Опубликована: Янв. 1, 2024
More
than
5
years
have
passed
since
the
Diffusion
Tensor
Image
Analysis
ALong
Perivascular
Space
(DTI-ALPS)
method
was
proposed
with
intention
of
evaluating
glymphatic
system.
This
is
handy
due
to
its
noninvasiveness,
provision
a
simple
index
in
straightforward
formula,
and
possibility
retrospective
analysis.
Therefore,
ALPS
adopted
evaluate
system
for
many
disorders
studies.
The
purpose
this
review
look
back
discuss
at
moment.
Brain,
Год журнала:
2023,
Номер
147(1), С. 100 - 108
Опубликована: Авг. 16, 2023
Abstract
Recently,
an
astrocytic
aquaporin
4-dependent
drainage
system,
that
is,
the
glymphatic
has
been
identified
in
live
murine
and
human
brain.
Growing
evidence
suggests
function
is
impaired
patients
with
several
neurodegenerative
diseases,
including
Alzheimer’s
Parkinson’s
disease.
As
third
most
common
disease,
although
animal
studies
have
indicated
early
dysfunction
likely
important
pathological
mechanism
underpinning
amyotrophic
lateral
sclerosis
(ALS),
no
available
study
conducted
to
thoroughly
assess
vivo
ALS
date,
particularly
early-stage
ALS.
Thus,
using
diffusion
tensor
imaging
analysis
along
perivascular
space
(ALPS)
index,
approximate
measure
of
vivo,
we
aimed
explore
whether
ALS,
diagnostic
performance
ALPS
index
distinguishing
between
healthy
subjects.
We
also
identify
relationships
clinical
disabilities
sleep
problems
In
this
retrospective
study,
King’s
Stage
1
were
defined
as
enrolled
56
32
age-
sex-matched
control
All
participants
completed
screening,
assessment
analysis.
For
assessment,
Pittsburgh
Sleep
Quality
Index,
Epworth
Sleepiness
Scale
polysomnography
used.
Compared
subjects,
had
a
significantly
lower
after
family-wise
error
correction
(P
<
0.05).
Moreover,
receiver
operating
characteristic
showed
area
under
curve
for
was
0.792
(95%
confidence
interval
0.700–0.884).
Partial
correlation
analyses
correlated
disability
disturbances
Multivariate
efficiency
(r
=
0.419,
P
0.002)
periodic
limb
movements
−0.294,
0.017)
significant
predictive
factors
conclusion,
our
continues
support
role
pathology,
provide
additional
insights
into
value
its
suggest
improvement
may
be
promising
strategy
slowing
process
Future
are
needed
therapeutic
individuals
presymptomatic-stage
diseases.
NMR in Biomedicine,
Год журнала:
2024,
Номер
37(9)
Опубликована: Май 7, 2024
Abstract
Cerebrospinal
fluid
(CSF)
plays
a
critical
role
in
metabolic
waste
clearance
from
the
brain,
requiring
its
circulation
throughout
various
brain
pathways,
including
ventricular
system,
subarachnoid
spaces,
para‐arterial
interstitial
and
para‐venous
spaces.
The
complexity
of
CSF
has
posed
challenge
obtaining
noninvasive
measurements
dynamics.
assessment
dynamics
circulatory
pathways
is
possible
using
diffusion
magnetic
resonance
imaging
(MRI)
with
optimized
sensitivity
to
incoherent
water
movement
across
brain.
This
review
presents
an
overview
both
established
emerging
MRI
techniques
designed
measure
their
potential
clinical
applications.
discussion
offers
insights
into
optimization
acquisition
parameters
enhance
specificity
metrics
on
underlying
Lastly,
we
emphasize
importance
cautious
interpretations
diffusion‐based
imaging,
especially
when
differentiating
between
tissue‐
fluid‐related
changes
or
elucidating
structural
versus
functional
alterations.
Japanese Journal of Radiology,
Год журнала:
2024,
Номер
42(10), С. 1146 - 1156
Опубликована: Май 31, 2024
Abstract
Purpose
To
investigate
glymphatic
system
function
in
patients
with
brain
tumors,
including
both
primary
and
secondary
using
diffusion
tensor
imaging
along
perivascular
spaces
(DTI-ALPS).
Methods
We
retrospectively
analyzed
the
MR
DTI
of
24
unilateral
tumors
compared
them
age
sex-matched
controls.
DTI-ALPS
index
ipsi-
contralateral
hemispheres.
The
region
interest
was
placed
periventricular
vessels
adjacent
to
lateral
ventricles.
Differences
between
sex,
age,
kind
tumor
(primary
or
metastasis)
were
evaluated.
Correlations
tumor's
apparent
coefficient
(ADC)
also
investigated.
Results
significantly
lower
(
p
<
0.05)
tumor-affected
hemisphere
(mean
=
1.26
±
0.24)
than
1.43
0.28).
A
comparison
healthy
controls
revealed
no
significant
difference
on
matched
ipsilateral
side.
However,
side
larger
HC.
Additionally,
statistically
differences
found
when
analyzing
vs.
entity.
we
did
not
find
a
correlation
patient
ADC.
Conclusion
decreased
may
be
related
impaired
function.
cancer
is
often
systemic
disease;
thus,
from
generally
considered
as
normal
control.
Nonetheless,
does
only
reflect
but
it
can
influenced
by
factors
such
axonal
degeneration.
Therefore,
directly
waste
clearance
changes
should
interpreted
carefully.
Sleep Medicine,
Год журнала:
2024,
Номер
119, С. 399 - 405
Опубликована: Май 3, 2024
The
recently
discovered
glymphatic
system
may
support
the
removal
of
neurotoxic
proteins,
mainly
during
sleep,
that
are
associated
with
neurodegenerative
diseases
such
as
Alzheimer's
and
Parkinson's
Disease.
Diffusion
tensor
image
analysis
along
perivascular
space
(DTI-ALPS)
has
been
suggested
a
method
to
index
health
(with
higher
values
indicating
more
intact
system).
Indeed,
in
small-scale
studies
DTI-ALPS
shown
correlate
age,
cognitive
health,
is
females
than
males.
To
determine
whether
these
relationships
stable
we
replicated
previous
findings
associating
demographic,
sleep-related,
markers
large
sample
participants
from
UK
Biobank.
We
calculated
Biobank
(n
=
17723).
Using
Bayesian
Frequentist
approaches,
replicate
previously
reported
between
index.
found
predicted
associations
longest
uninterrupted
sleep
window
(LUSWT)
on
typical
night,
performance,
sex.
However,
effects
were
substantially
smaller
those
studies.
Parameter
estimates
this
study
be
used
priors
subsequent
using
approach.
These
results
suggest
consistently,
therefore
predictably,
demographics,
LUWST,
cognition.
propose
metric,
for
first
time
large-scale,
population-based
cohort,
measure,
but
one
which
stronger
links
function
needed
before
it
can
understand
outcomes
UKBiobank.
Journal of Cerebral Blood Flow & Metabolism,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 25, 2024
We
discuss
two
potential
non-invasive
MRI
methods
to
study
phenomena
related
subarachnoid
cerebrospinal
fluid
(CSF)
motion
and
perivascular
transport,
their
association
with
sleep
aging.
apply
diffusion-based
intravoxel
incoherent
(IVIM)
imaging
evaluate
pseudodiffusion
coefficient,
D*,
or
CSF
movement
across
large
spaces
like
the
space
(SAS).
also
performed
perfusion-based
multi-echo,
Hadamard
encoded
arterial
spin
labeling
(ASL)
whole
brain
cortical
cerebral
blood
flow
(CBF)
trans-endothelial
exchange
(
T
ex
)
of
water
from
vasculature
into
parenchyma.
Both
were
used
in
young
adults
(N
=
9,
6
F,
23
±
3
years
old)
setting
deprivation.
To
aging,
10
older
(6
67
imaged
after
a
night
normal
compared
adults.
D*
SAS
was
significantly
(p
<
0.05)
reduced
deprivation
(0.016
0.001
mm
2
/s)
(0.018
marginally
aging
(0.017
/s,
p
0.029).
Cortical
CBF
unchanged
but
lower
(37
ml/100
g/min,
578
61
ms)
than
(42
696
62
ms).
IVIM
sensitive
physiology
multi-delay
ASL
