The Potential of cfDNA as Biomarker: Opportunities and Challenges for Neurodegenerative Diseases DOI Creative Commons
Şeyma Aydın, Selçuk Özdemir, Ahmet Adıgüzel

и другие.

Journal of Molecular Neuroscience, Год журнала: 2025, Номер 75(1)

Опубликована: Март 13, 2025

Abstract Neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), and amyotrophic lateral (ALS), are characterized by the progressive gradual degeneration of neurons. The prevalence rates these disorders rise significantly with age. As life spans continue to increase in many countries, number cases is expected grow foreseeable future. Early precise diagnosis, along appropriate surveillance, continues pose a challenge. high heterogeneity neurodegenerative diseases calls for more accurate definitive biomarkers improve clinical therapy. Cell-free DNA (cfDNA), fragmented released into bodily fluids via apoptosis, necrosis, or active secretion, has emerged as promising non-invasive diagnostic tool various diseases. cfDNA can serve an indicator ongoing cellular damage mortality, neuronal loss, may provide valuable insights processes, progression, therapeutic responses. This review will first cover key aspects then examine recent advances its potential use biomarker disorders.

Язык: Английский

Energy metabolism in health and diseases DOI Creative Commons
Hui Liu, Shuo Wang, Jianhua Wang

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

5
Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence DOI Creative Commons

Enzo Pereira de Lima,

Lucas Fornari Laurindo,

Vitor Cavallari Strozze Catharin

и другие.

Metabolites, Год журнала: 2025, Номер 15(2), С. 124 - 124

Опубликована: Фев. 13, 2025

Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation structure, or loss function, leading to substantially reduced quality life. They remain significant focus scientific and clinical interest due their increasing medical social importance. Most neurodegenerative present intracellular protein aggregation extracellular deposition (plaques), such as α-synuclein in Parkinson's disease amyloid beta (Aβ)/tau aggregates Alzheimer's. Conventional treatments for conditions incur high costs are related the development several adverse effects. In addition, many patients irresponsive them. For these reasons, there is growing tendency find new therapeutic approaches help patients. This review intends investigate some phytocompounds' effects on diseases. These generally increased oxidative stress inflammation, so phytocompounds can prevent treat To achieve our aim provide critical assessment current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, COCHRANE, seeking trials that utilized against conditions. A few investigated humans, after screening, 13 were ultimately included following PRISMA guidelines. compounds include polyphenols (flavonoids luteolin quercetin, phenolic acids rosmarinic acid, ferulic caffeic other like resveratrol), alkaloids (such berberine, huperzine A, caffeine), terpenoids ginkgolides limonene). The gathered evidence underscores caffeine, ginkgolides, primarily anti-inflammatory, antioxidant, neuroprotective, counteracting neuroinflammation, oxidation, synaptic dysfunctions, which crucial aspects intervention various conditions, Alzheimer's dementias, depression, neuropsychiatric disorders. summary, they show use improvements cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, mood

Язык: Английский

Процитировано

4
Recent Advances in the Mechanisms of Postoperative Neurocognitive Dysfunction: A Narrative Review DOI Creative Commons
Tingting Wang, Xin Huang, Shujun Sun

и другие.

Biomedicines, Год журнала: 2025, Номер 13(1), С. 115 - 115

Опубликована: Янв. 7, 2025

Postoperative neurocognitive dysfunction (PND) is a prevalent and debilitating complication in elderly surgical patients, characterized by persistent cognitive decline that negatively affects recovery quality of life. As the aging population grows, rising number patients has made PND an urgent clinical challenge. Despite increasing research efforts, pathophysiological mechanisms underlying remain inadequately characterized, underscoring need for more integrated framework to guide targeted interventions. To better understand molecular therapeutic targets PND, this narrative review synthesized evidence from peer-reviewed studies, identified through comprehensive searches PubMed, Embase, Cochrane Library, Web Science. Key findings highlight neuroinflammation, oxidative stress, mitochondrial dysfunction, neurotransmitter imbalances, microvascular changes, white matter lesions as central pathophysiology, with particular parallels encephalocele- sepsis-associated impairments. Among these, mediated pathways such NLRP3 inflammasome blood-brain barrier disruption, emerges pivotal driver, triggering cascades exacerbate neuronal injury. Oxidative stress synergistically amplify these effects, while imbalances alterations, including lesions, contribute synaptic decline. Anesthetic agents modulate interconnected pathways, exhibiting both protective detrimental effects. Propofol dexmedetomidine demonstrate neuroprotective properties suppressing neuroinflammation microglial activation, whereas inhalational anesthetics like sevoflurane intensify inflammatory responses. Ketamine, its anti-inflammatory potential, offers promise but requires further evaluation determine long-term safety efficacy. By bridging insights practice, highlights critical role personalized anesthetic strategies mitigating improving patients. It aims inform future decision-making address multifaceted

Язык: Английский

Процитировано

2
Regulatory roles of microRNAs in modulating mitochondrial dynamics, amyloid beta fibrillation, microglial activation, and cholinergic signaling: Implications for alzheimer's disease pathogenesis DOI
Monika Sharma, Ankur Kumar Tanwar,

Paresh Kumar Purohit

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 161, С. 105685 - 105685

Опубликована: Апрель 25, 2024

Язык: Английский

Процитировано

11
New Insights into Mitochondria in Health and Diseases DOI Open Access
Ya Li, Huhu Zhang,

Chunjuan Yu

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 9975 - 9975

Опубликована: Сен. 16, 2024

Mitochondria are a unique type of semi-autonomous organelle within the cell that carry out essential functions crucial for cell's survival and well-being. They location where eukaryotic cells energy metabolism. Aside from producing majority ATP through oxidative phosphorylation, which provides cellular functions, mitochondria also participate in other metabolic processes cell, such as electron transport chain, citric acid cycle, β-oxidation fatty acids. Furthermore, regulate production elimination ROS, synthesis nucleotides amino acids, balance calcium ions, process death. Therefore, it is widely accepted mitochondrial dysfunction factor causes or contributes to development advancement various diseases. These include common systemic diseases, aging, diabetes, Parkinson's disease, cancer, well rare disorders, like Kearns-Sayre syndrome, Leigh myopathy. This overview outlines mechanisms by involved numerous illnesses physiological activities. Additionally, new discoveries regarding involvement both disorders maintenance good health.

Язык: Английский

Процитировано

8
Neurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, H2S overproduction, altered protein persulfidation, synaptic dysfunction, endoplasmic reticulum stress, and autophagy DOI Creative Commons

Theodora Panagaki,

Lucia Janickova,

Dunja Petrovic

и другие.

GeroScience, Год журнала: 2024, Номер 46(5), С. 4275 - 4314

Опубликована: Апрель 1, 2024

Down syndrome (DS) is a genetic condition where the person born with an extra chromosome 21. DS associated accelerated aging; people are prone to age-related neurological conditions including early-onset Alzheimer's disease. Using Dp(17)3Yey/ + mice, which overexpresses portion of mouse 17, encodes for transsulfuration enzyme cystathionine β-synthase (CBS), we investigated functional role CBS/hydrogen sulfide (H

Язык: Английский

Процитировано

7
Recent advances of honokiol：pharmacological activities, manmade derivatives and structure-activity relationship DOI
Xiuxia Li,

Zhuo Yuan,

Yu-Xia Wang

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 272, С. 116471 - 116471

Опубликована: Апрель 30, 2024

Язык: Английский

Процитировано

6
Antioxidant and anti-Alzheimer's disease activities of 1,8-cineole and its cyclodextrin inclusion complex DOI Open Access
Xin Tan, Rui Xu,

А. А. Ли

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116784 - 116784

Опубликована: Май 22, 2024

1,8-Cineole is a bicyclic monoterpene widely distributed in the essential oils of various medicinal plants, and it exhibits significant anti-inflammatory antioxidant activities. We aimed to investigate therapeutic effect 1,8-cineole on anti-Alzheimer's disease by using transgenic Caenorhabditis elegans models. Our studies demonstrated that significantly relieved Aβ1–42-induced paralysis exhibited remarkable anti-Aβ1–42 aggregation activities nematodes CL4176, CL2006 CL2355. developed 1,8-cineole/cyclodextrin inclusion complex, displaying enhanced anti-paralysis, anti-Aβ compared 1,8-cineole. In addition, we found treatment activated SKN-1/Nrf-2 pathway induced autophagy nematodes. results 1,8-cineole, which provide potential approach for Alzheimer's disease.

Язык: Английский

Процитировано

6
Nrf2 pathways in neuroprotection: Alleviating mitochondrial dysfunction and cognitive impairment in aging DOI
Asif Ahmad Bhat, Ehssan Moglad, Ahsas Goyal

и другие.

Life Sciences, Год журнала: 2024, Номер 357, С. 123056 - 123056

Опубликована: Сен. 12, 2024

Язык: Английский

Процитировано

6
Mitochondrial Aconitase and Its Contribution to the Pathogenesis of Neurodegenerative Diseases DOI Open Access
Volodymyr Padalko, Filip Posnik, Małgorzata Adamczyk

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 9950 - 9950

Опубликована: Сен. 15, 2024

This survey reviews modern ideas on the structure and functions of mitochondrial cytosolic aconitase isoenzymes in eukaryotes. Cumulative experimental evidence about aconitases (Aco2) as one main targets reactive oxygen nitrogen species is generalized. The important role Aco2 maintenance homeostasis intracellular iron pool DNA discussed. pathogenesis some neurodegenerative diseases highlighted. Inactivation or dysfunction well mutations found ACO2 gene appear to be significant factors development promotion various types diseases. A restoration efficient functioning a source energy for cell by targeting seems promising therapeutic directions minimize progressive disorders.

Язык: Английский

Процитировано

5