Unveiling the emerging concern of per- and polyfluoroalkyl substances (PFAS) and their potential impacts on estuarine ecosystems

Marine Pollution Bulletin, Год журнала: 2025, Номер 212, С. 117554 - 117554

Опубликована: Янв. 20, 2025

Язык: Английский

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Research Progress in Current and Emerging Issues of PFASs’ Global Impact: Long-Term Health Effects and Governance of Food Systems

Foods, Год журнала: 2025, Номер 14(6), С. 958 - 958

Опубликована: Март 11, 2025

Per- and polyfluoroalkyl substances (PFASs) are found everywhere, including food, cosmetics, pharmaceuticals. This review introduces PFASs comprehensively, discussing their nature identifying interconnection with microplastics impacts on public health the environment. The human cost of decades delay, cover-ups, mismanagement plastic waste is outlined briefly explained. Following that, long-term effects critically assessed. Risk assessment then reviewed, mentioning different tools models. Scientific research in United States America analyzed, taking into consideration Center for Disease Control (CDC)'s PFAS Medical Studies Guidelines. impact activities studies around world have focused levels food products dietary intake countries such as China, European countries, USA Australia. Moreover, drinking water regard to risks, mitigation, regulatory needs, account chemical contaminants safety. Finally, briefings specific regions discussed, referring Australia, Vietnam, Canada, Europe, (USA), South America, Africa. crisis a multifaceted issue, exacerbated by mismanagement, it discussed context applying following problem-solving analytical tools: Domino Effect Model accident causation, Swiss Cheese Theory Model, Ishikawa Fish Bone Root Cause Analysis. Last but not least, PFASs' Sustainable Development Goals (SDGs) 2030 rigorously discussed.

Язык: Английский

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Association Between Serum Levels of Perfluoroalkyl and Polyfluoroalkyl Substances and Dental Floss Use: The Double‐Edged Sword of Dental Floss Use—A Cross‐Sectional Study

Journal Of Clinical Periodontology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

ABSTRACT Background Although evidence suggests that dental floss contains perfluoroalkyl and polyfluoroalkyl substances (PFASs), it is still uncertain whether the use of contributes to an increased risk PFAS exposure. Methods We analysed data on serum concentrations usage in a cohort 6750 adults who participated National Health Nutrition Examination Survey (NHANES) from 2009 2020. In our study, we used logistic regression, survey‐weighted linear model, item response theory (IRT) scores, inverse probability weights (IPWs) sensitivity analysis assess potential impact human levels. Results The six PFASs revealed users had higher perfluorooctanoic acid (PFOA) compared with non‐users, while other were lower. Dental recorded lower level overall burden score non‐users. Sensitivity showed statistically significant increase PFOA concentration among users. Conclusion Our findings suggest may be associated differently specific PFASs. Among large representative sample U.S. adults, individuals reporting levels overall, exception PFOA, which was slightly elevated. important oral hygiene tool, further research needed clarify its role

Язык: Английский

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Broad PFAS binding with fatty acid binding protein 4 is enabled by variable binding modes.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Abstract Per- and polyfluoroalkyl substances (PFAS) are ubiquitous pollutants that bioaccumulate in wildlife humans, yet the molecular basis of their protein interactions remains poorly understood. Here, we show human adipocyte fatty acid-binding (FABP4) can bind a diverse array PFAS, including next-generation replacements for legacy chemicals longer-chain perfluorocarboxylic acids. Shorter-chain although weaker binders, still displayed measurable affinities—surpassing those nonfluorinated analogs. We determined crystal structures FABP4 bound to perfluorooctanoic acid (PFOA), perfluorodecanoic (PFDA), perfluorohexadecanoic (PFHxDA), revealing three distinct binding modes. Notably, PFOA binds two separate sites, conformations define single-ligand PFDA PFHxDA. These arrangements enhance hydrophobic within cavity likely explain low micromolar dissociation constants observed fluorescence competition assays. Our findings underscore critical roles chain length, headgroup functionality, conformation PFAS–FABP4 interactions. Given emerging implications role endocrine function, even subtle PFAS-induced perturbations could affect metabolic regulation disease risk. Overall, this work highlights value direct structural biochemical insights into paves way future research on PFAS transport toxicological outcomes.

Язык: Английский

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Computational Study of the Gas-Phase Thermal Degradation and the Reaction Rate Coefficients of Perfluoroalkyl Ether Carboxylic Acids

The Journal of Physical Chemistry A, Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

Perfluoroalkyl ether carboxylic acids (PFECA), which are replacements for legacy per- and polyfluorinated alkyl substances (PFAS), exhibit undesirable properties often require thermal remediation. Detailed kinetic evaluation of the pyrolysis PFECA was achieved computationally using density functional ωB97xD/6-311+G (d,p) to establish homolytic bond dissociation energies acid carboxylate forms ∼90-100 kcal/mol as low 65 ± 3 kcal/mol, respectively. The negatively charged oxygenated radical products collapse with activation (Ea) Ea(β-scission) ∼ 12-42 Ea(1,2-F-shift) 24-47 Ea(oxygen atom-shift) 33-35 enthalpies (ΔH) ΔH(F-loss) 56-71 kcal/mol. perfluoroalkoxyl intermediates transform via Ea(β scission) 2-9 Ea(F-loss) 25-43 have lifetimes in microsecond-to-nanosecond range at 1000 K 1 atm, some radicals stable hours or even days respect unimolecular processes. results provide new fundamental thermodynamic parameters partitioning degradation pathways specific structure-activity relationships intermediates, leading final products. These critical modeling treatment related PFAS.

Язык: Английский

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The sources and bioaccumulation of per- and polyfluoroalkyl substances in animal-derived foods and the potential risk of dietary intake

The Science of The Total Environment, Год журнала: 2023, Номер 905, С. 167313 - 167313

Опубликована: Сен. 22, 2023

Язык: Английский

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Harnessing carbon-based adsorbents for poly- and perfluorinated substance removal: A comprehensive review

Journal of Water Process Engineering, Год журнала: 2024, Номер 69, С. 106621 - 106621

Опубликована: Ноя. 22, 2024

Язык: Английский

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Impact of perfluorooctanoic acid (PFOA) and perfluorobutanoic acid (PFBA) on oxidative stress and metabolic biomarkers in human neuronal cells (SH-SY5Y)

Environment International, Год журнала: 2024, Номер 190, С. 108864 - 108864

Опубликована: Июль 2, 2024

Perfluorinated alkyl substances (PFAS) are pervasive environmental contaminants that have attracted considerable attention due to their widespread utilization, resilient characteristics, adverse health implications, and regulatory scrutiny. Despite documented toxicity in living organisms, the precise molecular mechanisms governing induced effects remain unclear. This study aims elucidate of toxic action by collecting empirical data sets along oxidative stress metabolic disruption pathways. We investigated impact long-chain PFAS (perfluorooctanoic acid (PFOA)) its short-chain analog (perfluorobutanoic (PFBA)) on human neuronal cells (SH-SY5Y). The functionalities enzymes associated with (catalase glutathione reductase) cellular metabolism (lactate dehydrogenase pyruvate dehydrogenase) were also characterized. Our results reveal a 24-hour exposure PFOA PFBA generated significant levels reactive oxygen species. Correspondingly, there was notable decline catalase reductase activities, demonstrating more pronounced effect. High concentrations reduced activity. Lactate activity only impacted high concentration PFBA, while decreased increased exposure. findings from this contribute knowledge cell interactions potential underlying PFAS-induced toxicity.

Язык: Английский

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Effect of physicochemical parameters on the occurrence of per- and polyfluoroalkyl substances (PFAS) in aquatic environment

Marine Pollution Bulletin, Год журнала: 2024, Номер 208, С. 117040 - 117040

Опубликована: Окт. 3, 2024

Язык: Английский

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Suspect and nontarget screening of per- and polyfluoroalkyl substances based on ion mobility mass spectrometry and machine learning techniques

Journal of Hazardous Materials, Год журнала: 2023, Номер 461, С. 132669 - 132669

Опубликована: Сен. 29, 2023

Язык: Английский

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