Journal of Hepato-Biliary-Pancreatic Sciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 6, 2024
The
choice
between
22-gauge
endoscopic
ultrasound-guided
fine-needle
biopsy
(EUS-FNB)
and
EUS-guided
aspiration
(EUS-FNA)
for
histological
diagnosis
of
type
1
autoimmune
pancreatitis
(AIP)
is
unclear.
We
retrospectively
examined
the
detection
rate
findings
AIP
using
EUS-FNA/FNB.
Patients
diagnosed
with
EUS-FNB
(Franseen
needle)
or
EUS-FNA
(conventional
needles
at
our
hospital
2012
2023
were
included
in
this
study.
was
according
to
International
Consensus
Diagnostic
Criteria
(ICDC).
rates
level
findings,
which
storiform
fibrosis
and/or
obliterative
phlebitis,
2
evaluated
ICDC.
groups
25
24
patients,
respectively.
No
significant
differences
patient
background
noted
two
groups.
prominent
filtration
lymphocytes
plasma
cells
along
56.0%
group
12.5%
(p
=
.001).
more
than
10
IgG4-positive
per
high-power
microscopic
field
68.0%
29.2%
groups,
respectively
.007).
levels
significantly
higher
(56.0%
vs.
12.5%;
p
Mild
observed
group;
however,
no
other
serious
adverse
events
occurred.
yielded
a
EUS-FNA,
suggesting
that
suitable
safe
AIP.
Rheumatology & autoimmunity,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Abstract
Immunoglobulin
G4‐related
disease
(IgG4‐RD)
is
a
systemic
fibro‐inflammatory
characterized
by
tumefactive
lesions.
Beyond
the
role
of
as
cancer
mimic,
studies
over
past
decade
have
demonstrated
that
IgG4‐RD
associated
with
increased
risk.
A
search
articles,
case
reports,
and
reviews
concerning
malignancies
in
patients
was
conducted
on
PubMed,
Web
Science,
Google
Scholar.
The
site
development
not
always
affected
IgG4‐RD.
prevalence
solid
cancers
varies
among
populations.
Moreover,
B‐cell
neoplasms
constitute
proportion
linked
to
this
disease.
precise
mechanism
oncogenesis
ambiguous.
Several
mechanisms
may
be
relevant
risk
IgG4‐RD,
including
chronic
inflammation,
IgG4‐positive
plasma
cell
infiltration,
involvement
follicular
helper
T
cells,
macrophages,
plasmacytoid
dendritic
cells
tumor
immunity.
factors
include
male
sex,
older
age,
smoking
status,
occupational
exposure,
recurrence,
specific
organs.
Malignancies
are
poor
prognosis,
underscoring
importance
management
regular
screening
during
follow‐up.
linking
malignancy
remain
unclear
warrant
further
research.
Regular
should
prioritized
follow‐up
facilitate
early
detection
malignancies.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 30, 2024
Background
Hepatic
Inflammatory
Pseudotumor
(IPT)
is
an
infrequent
condition
often
masquerading
as
a
malignant
tumor,
resulting
in
misdiagnosis
and
unnecessary
surgical
resection.
The
emerging
concept
of
IgG4-related
diseases
(IgG4-RD)
has
gained
widespread
recognition,
encompassing
entities
like
hepatic
IPT.
Clinically
radiologically,
corticosteroids
immunosuppressive
therapies
have
proven
effective
managing
this
condition.
Case
Presentation
A
3-year-old
Chinese
boy
presented
to
the
clinic
with
11-month
history
anemia,
fever
unknown
origin,
tender
mass.
Blood
examinations
revealed
chronic
anemia
(Hb:
6.4
g/L,
MCV:
68.6
fl,
MCH:
19.5
pg,
reticulocytes:
1.7%)
accompanied
by
inflammatory
reaction
elevated
serum
IgG4
level
(1542.2
mg/L).
Abdominal
contrast-enhanced
computed
tomography
unveiled
7.6
cm
low-density
mass
right
lateral
lobe,
while
magnetic
resonance
imaging
demonstrated
slight
hypointensity
on
T1-weighted
images
hyperintensity
T2-weighted
images,
prompting
suspicion
malignancy.
subsequent
liver
biopsy
characterized
fibrous
stroma
dense
lymphoplasmacytic
infiltration.
Immunohistochemical
analysis
confirmed
presence
IgG4-positive
plasma
cells,
leading
diagnosis
Swift
resolution
occurred
upon
initiation
corticosteroid
mycophenolate
mofetil
therapies.
Conclusion
This
study
underscores
diagnostic
approach
IPT,
utilizing
histopathology,
immunostaining,
imaging,
serology,
organ
involvement,
therapeutic
response.
Early
histological
examination
plays
pivotal
role
clinical
guidance,
averting
tumor
interventions.
United European Gastroenterology Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 21, 2024
ABSTRACT
Autoimmune
pancreatitis
is
an
increasingly
recognized
inflammatory
type
of
subacute
pancreatitis;
two
subtypes
autoimmune
have
been
identified
so
far:
the
“lymphoplasmacytic”
1
variant
and
“neutrophilic”
2
variant.
Type
represents
most
common
manifestation
IgG4‐related
disease,
a
fibro‐inflammatory
disorder
characterized
by
elevated
IgG4
levels
in
serum
affected
tissues.
pancreas‐specific
that
frequently
occurs
context
bowel
diseases.
Due
to
complexity
both
diseases,
comprehensive
work
up
with
imaging,
laboratory,
histological
studies
required
achieve
diagnosis
rule
out
malignancies.
Glucocorticoids
represent
cornerstone
treatment,
often
supported
other
immunosuppressive
drugs
case
steroid
intolerance
or
aggressive
disease.
Maintenance
treatment
employed
because
higher
relapse
rate
compared
pancreatitis.
In
this
review,
we
summarize
key
concept
pancreatitis,
delve
into
differential
between
subtypes,
cover
recent
relevant
research
findings
pressing
unmet
needs.
Internal Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
A
50-year-old
man
was
diagnosed
with
type
1
autoimmune
pancreatitis
(AIP)
following
endoscopic
ultrasound-guided
fine-needle
aspiration
(EUS-FNA)
and
a
histopathological
examination.
After
six
months
of
untreated
follow-up,
the
serum
IgG4
level
decreased,
diffuse
pancreatic
enlargement
improved;
however,
head
mass
became
apparent.
EUS-FNA
this
revealed
ductal
adenocarcinoma
(PDAC)
IgG4-positive
plasma
cells.
In
addition,
resected
specimen
PDAC,
without
any
features
AIP.
pancreatoduodenectomy,
AIP
did
not
recur.
The
development
in
case
could
be
related
to
paraneoplastic
syndrome.
