Update on Autoimmune Pancreatitis and IgG4‐Related Disease DOI Creative Commons
Marco Lanzillotta, Miroslav Vujasinović, Matthias Löhr

et al.

United European Gastroenterology Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

ABSTRACT Autoimmune pancreatitis is an increasingly recognized inflammatory type of subacute pancreatitis; two subtypes autoimmune have been identified so far: the “lymphoplasmacytic” 1 variant and “neutrophilic” 2 variant. Type represents most common manifestation IgG4‐related disease, a fibro‐inflammatory disorder characterized by elevated IgG4 levels in serum affected tissues. pancreas‐specific that frequently occurs context bowel diseases. Due to complexity both diseases, comprehensive work up with imaging, laboratory, histological studies required achieve diagnosis rule out malignancies. Glucocorticoids represent cornerstone treatment, often supported other immunosuppressive drugs case steroid intolerance or aggressive disease. Maintenance treatment employed because higher relapse rate compared pancreatitis. In this review, we summarize key concept pancreatitis, delve into differential between subtypes, cover recent relevant research findings pressing unmet needs.

Language: Английский

Pharmacological Management of IgG4-Related Disease: From Traditional to Mechanism-Based Targeted Therapies DOI
Mitsuhiro Akiyama, Waleed Alshehri, Koichi Saito

et al.

Drugs & Aging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Language: Английский

Citations

0
Malignancies and immunoglobulin G4‐related disease DOI Creative Commons
Jingna Li, Wen Zhang

Rheumatology & autoimmunity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Immunoglobulin G4‐related disease (IgG4‐RD) is a systemic fibro‐inflammatory characterized by tumefactive lesions. Beyond the role of as cancer mimic, studies over past decade have demonstrated that IgG4‐RD associated with increased risk. A search articles, case reports, and reviews concerning malignancies in patients was conducted on PubMed, Web Science, Google Scholar. The site development not always affected IgG4‐RD. prevalence solid cancers varies among populations. Moreover, B‐cell neoplasms constitute proportion linked to this disease. precise mechanism oncogenesis ambiguous. Several mechanisms may be relevant risk IgG4‐RD, including chronic inflammation, IgG4‐positive plasma cell infiltration, involvement follicular helper T cells, macrophages, plasmacytoid dendritic cells tumor immunity. factors include male sex, older age, smoking status, occupational exposure, recurrence, specific organs. Malignancies are poor prognosis, underscoring importance management regular screening during follow‐up. linking malignancy remain unclear warrant further research. Regular should prioritized follow‐up facilitate early detection malignancies.

Language: Английский

Citations

0
Association of autoimmune pancreatitis and intraductal papillary mucinous neoplasm. A retrospective analysis from a tertiary care referral center DOI
Marco Lanzillotta, Lino Iago Belli, Giulio Belfiori

et al.

Pancreatology, Journal Year: 2024, Volume and Issue: 24(3), P. 456 - 462

Published: March 1, 2024

Language: Английский

Citations

2
A case report of IgG4-related hepatic inflammatory pseudotumor in a 3-year old boy DOI Creative Commons

Qian Wan,

Zhongjin Xu,

Xiaohui Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 30, 2024

Background Hepatic Inflammatory Pseudotumor (IPT) is an infrequent condition often masquerading as a malignant tumor, resulting in misdiagnosis and unnecessary surgical resection. The emerging concept of IgG4-related diseases (IgG4-RD) has gained widespread recognition, encompassing entities like hepatic IPT. Clinically radiologically, corticosteroids immunosuppressive therapies have proven effective managing this condition. Case Presentation A 3-year-old Chinese boy presented to the clinic with 11-month history anemia, fever unknown origin, tender mass. Blood examinations revealed chronic anemia (Hb: 6.4 g/L, MCV: 68.6 fl, MCH: 19.5 pg, reticulocytes: 1.7%) accompanied by inflammatory reaction elevated serum IgG4 level (1542.2 mg/L). Abdominal contrast-enhanced computed tomography unveiled 7.6 cm low-density mass right lateral lobe, while magnetic resonance imaging demonstrated slight hypointensity on T1-weighted images hyperintensity T2-weighted images, prompting suspicion malignancy. subsequent liver biopsy characterized fibrous stroma dense lymphoplasmacytic infiltration. Immunohistochemical analysis confirmed presence IgG4-positive plasma cells, leading diagnosis Swift resolution occurred upon initiation corticosteroid mycophenolate mofetil therapies. Conclusion This study underscores diagnostic approach IPT, utilizing histopathology, immunostaining, imaging, serology, organ involvement, therapeutic response. Early histological examination plays pivotal role clinical guidance, averting tumor interventions.

Language: Английский

Citations

2
Serum IgG4-negative and IgG4-positive type 1 autoimmune pancreatitis present with different clinicopathological features: an analysis of a nationwide survey in Japan DOI Creative Commons
Takanori Sano,

Kazuhiro Kikuta,

Tetsuya Takikawa

et al.

Pancreatology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

1
Risk factors to to monitor to facilitate early diagnosis of pancreatic cancer DOI
Atsushi Kanno,

Akitsugu Tanaka,

Yusuke Sakurai

et al.

Suizo, Journal Year: 2024, Volume and Issue: 39(4), P. 205 - 214

Published: Aug. 29, 2024

膵癌の予後は不良であり,早期に診断し治療することが望まれる.そのためには,危険因子を同定し,患者群を限定することが求められる.現在まで,家族性膵癌,遺伝性膵癌症候群,膵管内乳頭粘液性腫瘍,膵嚢胞,慢性膵炎,糖尿病など様々な膵癌の危険因子が同定されている.また,自己免疫性膵炎の膵癌発生率が高いことが報告されるなど,新たな膵癌の危険因子も同定されつつある.これらの膵癌発生の危険因子から効率のよいサーベイランス法が実行され,膵癌の早期診断症例が増加し,予後改善へ寄与することが期待される.

Language: Английский

Citations

0
What Is the Latest in Autoimmune Pancreatitis DOI

Krystal C Mills,

Shounak Majumder

Gastroenterology Clinics of North America, Journal Year: 2024, Volume and Issue: 54(1), P. 245 - 258

Published: Oct. 10, 2024

Language: Английский

Citations

0
Pancreatic Ductal Adenocarcinoma with Autoimmune Pancreatitis: A Case Report and Literature Review DOI Open Access
Yusuke Sakurai, Kensuke Yokoyama, Atsushi Kanno

et al.

Internal Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A 50-year-old man was diagnosed with type 1 autoimmune pancreatitis (AIP) following endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and a histopathological examination. After six months of untreated follow-up, the serum IgG4 level decreased, diffuse pancreatic enlargement improved; however, head mass became apparent. EUS-FNA this revealed ductal adenocarcinoma (PDAC) IgG4-positive plasma cells. In addition, resected specimen PDAC, without any features AIP. pancreatoduodenectomy, AIP did not recur. The development in case could be related to paraneoplastic syndrome.

Language: Английский

Citations

0
Endoscopic ultrasound‐guided fine‐needle biopsy needle can facilitate histological diagnosis of type 1 autoimmune pancreatitis DOI Open Access
Yusuke Kurita, Kensuke Kubota,

J Harada

et al.

Journal of Hepato-Biliary-Pancreatic Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

The choice between 22-gauge endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) and EUS-guided aspiration (EUS-FNA) for histological diagnosis of type 1 autoimmune pancreatitis (AIP) is unclear. We retrospectively examined the detection rate findings AIP using EUS-FNA/FNB. Patients diagnosed with EUS-FNB (Franseen needle) or EUS-FNA (conventional needles at our hospital 2012 2023 were included in this study. was according to International Consensus Diagnostic Criteria (ICDC). rates level findings, which storiform fibrosis and/or obliterative phlebitis, 2 evaluated ICDC. groups 25 24 patients, respectively. No significant differences patient background noted two groups. prominent filtration lymphocytes plasma cells along 56.0% group 12.5% (p = .001). more than 10 IgG4-positive per high-power microscopic field 68.0% 29.2% groups, respectively .007). levels significantly higher (56.0% vs. 12.5%; p Mild observed group; however, no other serious adverse events occurred. yielded a EUS-FNA, suggesting that suitable safe AIP.

Language: Английский

Citations

0
Update on Autoimmune Pancreatitis and IgG4‐Related Disease DOI Creative Commons
Marco Lanzillotta, Miroslav Vujasinović, Matthias Löhr

et al.

United European Gastroenterology Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

ABSTRACT Autoimmune pancreatitis is an increasingly recognized inflammatory type of subacute pancreatitis; two subtypes autoimmune have been identified so far: the “lymphoplasmacytic” 1 variant and “neutrophilic” 2 variant. Type represents most common manifestation IgG4‐related disease, a fibro‐inflammatory disorder characterized by elevated IgG4 levels in serum affected tissues. pancreas‐specific that frequently occurs context bowel diseases. Due to complexity both diseases, comprehensive work up with imaging, laboratory, histological studies required achieve diagnosis rule out malignancies. Glucocorticoids represent cornerstone treatment, often supported other immunosuppressive drugs case steroid intolerance or aggressive disease. Maintenance treatment employed because higher relapse rate compared pancreatitis. In this review, we summarize key concept pancreatitis, delve into differential between subtypes, cover recent relevant research findings pressing unmet needs.

Language: Английский

Citations

0