Oxytocin-induced increases in cytokines and clinical effect on the core social features of autism: Analyses of RCT datasets

Brain Behavior and Immunity, Год журнала: 2024, Номер 118, С. 398 - 407

Опубликована: Март 8, 2024

Язык: Английский

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Severe PTSD is marked by reduced oxytocin and elevated vasopressin

Comprehensive Psychoneuroendocrinology, Год журнала: 2024, Номер 19, С. 100236 - 100236

Опубликована: Апрель 27, 2024

Neuroendocrine analyses of posttraumatic stress disorder (PTSD) have generally focused on hypothalamic-pituitary-adrenal (HPA) axis alterations. In the present analyses, we examine two additional neuroendocrine factors that been previously implicated in biological responses: oxytocin (OT) and arginine vasopressin (AVP). Here examined basal neuropeptide status military veterans clinically diagnosed with PTSD (n = 29) non-traumatized comparison groups previous exposure 11 SWAT trainees n 21 ultramarathon runners). patients showed low levels plasma OT high AVP. The ratio AVP/OT robustly related to status, emerged as a statistically plausible mediator relationships between number personal traumatic experiences subsequent symptom burden. Over course behavioral therapy for PTSD, measures significant but modest normalization. Plasma cortisol were not different among three groups. This study suggests ratios may represent predictor severe well potential treatment response biomarker.

Язык: Английский

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Acute, chronic and conditioned effects of intranasal oxytocin in the mu-opioid receptor knockout mouse model of autism: Social context matters

Neuropsychopharmacology, Год журнала: 2024, Номер 49(12), С. 1934 - 1946

Опубликована: Июль 17, 2024

Autism Spectrum Disorders (ASD) are neurodevelopmental disorders whose diagnosis relies on deficient social interaction and communication together with repetitive behaviours. Multiple studies have highlighted the potential of oxytocin (OT) to ameliorate behavioural abnormalities in animal models subjects ASD. Clinical trials, however, yielded disappointing results. Our study aimed at assessing effects different regimens OT administration Oprm1 null mouse model We assessed intranasal injected once doses (0.15, 0.3, 0.6 IU) time points (5, 15, 30 min) following administration, or chronically, ASD-related behaviours (social preference, stereotypies, anxiety, nociception)

Язык: Английский

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Acute, chronic and conditioned effects of intranasal oxytocin in the mu opioid receptor knockout mouse model of autism: social context matters

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 10, 2024

Abstract Autism Spectrum Disorders (ASD) are neurodevelopmental disorders whose diagnosis relies on deficient social interaction and communication together with repetitive behaviours. Multiple studies have highlighted the potential of oxytocin (OT) to ameliorate behavioural abnormalities in animal models subjects ASD. Clinical trials, however, yielded disappointing results. Our study aimed at challenging hypotheses accounting for such negative results by assessing effects different regimens OT administration Oprm1 null mouse model We assessed intranasal injected once doses time points following administration, or chronically, ASD-related behaviours +/+ -/- mice. then tested whether pairing injection experience would influence its outcome ASD-like core symptoms, measured gene expression several regions reward/social circuit. Acute improved behaviour mice a moderate dose (0.3 IU) shortly after (5 min). Effects non-social were limited. Chronic this maintained beneficial but was deleterious wild-type Finally, improvements greater longer lasting when administered context, while vasopressin receptor genes, as well marker genes striatal projection neurons, suppressed. highlight importance considering dosage context evaluating treatment Highlights limited mutant Oxytocin triggers longer-lasting within suppresses own key neuron markers

Язык: Английский

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R150S mutation in the human oxytocin receptor: gain-of-function effects and implication in autism spectrum disorder

Peptides, Год журнала: 2024, Номер 182, С. 171301 - 171301

Опубликована: Окт. 10, 2024

Язык: Английский

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White matter; SYNGAP1-related intellectual disability; vitamin D

The Transmitter, Год журнала: 2023, Номер unknown

Опубликована: Янв. 1, 2023

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