Neuroscience Research, Год журнала: 2022, Номер 181, С. 17 - 21
Опубликована: Май 14, 2022
Язык: Английский
Molecular and Cellular Endocrinology, Год журнала: 2022, Номер 546, С. 111572 - 111572
Опубликована: Янв. 20, 2022
The role of the intestinal microbiota as a regulator gut-brain axis signalling has risen to prominence in recent years. Understanding relationship between gut microbiota, metabolites it produces, and brain will be critical for subsequent development new therapeutic approaches, including identification novel psychobiotics. A key focus this regard have been short-chain fatty acids (SCFAs) produced by bacterial fermentation dietary fibre, which include butyrate, acetate, propionate. Ongoing research is focused on entry SCFAs into systemic circulation from lumen, their migration cerebral across blood barrier, potential exert acute chronic effects structure function. This review aims discuss our current mechanistic understanding direct indirect influence that function, behaviour physiology, inform future microbiota-targeted interventions disorders.
Язык: Английский
Процитировано
297
Ageing Research Reviews, Год журнала: 2021, Номер 70, С. 101397 - 101397
Опубликована: Июнь 30, 2021
An excess of saturated fatty acids and simple sugars in the diet is a known environmental risk factor Alzheimer's disease (AD) but holistic view interacting processes through which such may contribute to AD pathogenesis missing. We addressed this need extensive analysis published studies investigating effects western (WD) on development humans laboratory animals. reviewed WD-induced systemic alterations comprising metabolic changes, induction obesity adipose tissue inflammation, gut microbiota dysbiosis acceleration low-grade inflammation. Next we provide an overview evidence demonstrating that WD-associated drive impairment blood-brain barrier (BBB) neuroinflammation paralleled by accumulation toxic amyloid. Later these changes are followed dysfunction synaptic transmission, neurodegeneration finally memory cognitive impairment. conclude WD can trigger inflammaging, BBB induced inflammation play central role process. Moreover, concurrence Aβ dyshomeostasis, reciprocal interactions vicious cycle neurodegeneration, contradicts as primary AD. Given 2019 World Health Organization recommended focusing modifiable factors prevention, sequential, complex pathomechanisms initiated WD, lead from peripheral disturbances support future prevention strategies.
Язык: Английский
Процитировано
237
Molecular Neurodegeneration, Год журнала: 2022, Номер 17(1)
Опубликована: Март 5, 2022
The implication of gut microbiota in the control brain functions health and disease is a novel, currently emerging concept. Accumulating data suggest that exert its action at least part by modulating neuroinflammation. Given link between neuroinflammatory changes neuronal activity, it plausible may affect indirectly impacting microglia, key player Indeed, increasing evidence suggests interplay microglia synaptic dysfunction involve microbiota, among other factors. In addition to these indirect microglia-dependent actions on has been recently recognized could also activity directly stimulation vagus nerve.
Язык: Английский
Процитировано
201
Nutrients, Год журнала: 2022, Номер 14(3), С. 668 - 668
Опубликована: Фев. 5, 2022
Gut microbiota is emerging as a key regulator of many disease conditions and its dysregulation implicated in the pathogenesis several gastrointestinal extraintestinal disorders. More recently, gut microbiome alterations have been linked to neurodegeneration through increasingly defined brain axis, opening possibility for new microbiota-based therapeutic options. Although studies conducted unravel possible relationship between Alzheimer’s Disease (AD) progression, diagnostic potential approaches aiming at restoring eubiosis remain be fully addressed. In this narrative review, we briefly summarize role homeostasis health disease, present evidence AD patients. Based on these observations, then discuss how dysbiosis might exploited tool early advanced stages, examine prebiotics, probiotics, fecal transplantation, diets complementary interventions thus offering insights into diagnosis treatment devastating progressive disease.
Язык: Английский
Процитировано
162
Frontiers in Nutrition, Год журнала: 2022, Номер 9
Опубликована: Окт. 5, 2022
Prebiotics and probiotics play a positive role in promoting human nutrition health. are compounds that cannot be digested by the host, but can used fermented probiotics, so as to promote reproduction metabolism of intestinal for health body. It has been confirmed have clinical or care functions preventing controlling intestinal, respiratory, urogenital infections, allergic reaction, inflammatory bowel disease, irritable syndrome other aspects. However, there few systematic summaries these types, mechanisms action promotion relationship between prebiotics probiotic. Therefore, we summarized various types their individual mechanisms, mechanism tract. is hoped this review provide new ideas application future.
Язык: Английский
Процитировано
149
Nutrients, Год журнала: 2021, Номер 13(2), С. 690 - 690
Опубликована: Фев. 21, 2021
The gut microbiota (GM) represents a diverse and dynamic population of microorganisms about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies suggest GM can influence health host, several factors modify composition, such as diet, drug intake, lifestyle, geographical locations. Gut dysbiosis affect brain immune homeostasis through microbiota-gut-brain axis play key role pathogenesis neurodegenerative diseases, including dementia Alzheimer's disease (AD). relationship between AD is still elusive, but emerging evidence suggests it enhance secretion lipopolysaccharides amyloids may disturb intestinal permeability blood-brain barrier. In addition, promote hallmarks AD, oxidative stress, neuroinflammation, amyloid-beta formation, insulin resistance, ultimately causation neural death. Poor dietary habits aging, along with inflammatory responses due to dysbiosis, contribute AD. Thus, modulation probiotics, or fecal transplantation could represent potential therapeutics this review, we discuss therapeutic strategies modulate
Язык: Английский
Процитировано
144
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114985 - 114985
Опубликована: Июнь 11, 2023
The gut microbiota is indispensable for maintaining host health by enhancing the host's digestive capacity, safeguarding intestinal epithelial barrier, and preventing pathogen invasion. Additionally, exhibits a bidirectional interaction with immune system promotes of to mature. Dysbiosis microbiota, primarily caused factors such as genetic susceptibility, age, BMI, diet, drug abuse, significant contributor inflammatory diseases. However, mechanisms underlying diseases resulting from dysbiosis lack systematic categorization. In this study, we summarize normal physiological functions symbiotic in healthy state demonstrate that when occurs due various external factors, are lost, leading pathological damage lining, metabolic disorders, barrier damage. This, turn, triggers disorders eventually causes systems. These discoveries provide fresh perspectives on how diagnose treat unrecognized variables might affect link between illnesses need further studies extensive basic clinical research will still be required investigate relationship future.
Язык: Английский
Процитировано
120
Apmis, Год журнала: 2022, Номер 130(12), С. 690 - 705
Опубликована: Апрель 8, 2022
This narrative review seeks to examine the relationships between bacterial microbiomes and infectious disease. is achieved by detailing how different human host develop function, from earliest infant acquisitions of maternal environmental species through full development adulthood. Communication or communities within outside microbiome a factor in both maintenance homeostasis management threats external environment. Dysbiosis this key understanding disease states. Several microbiota are used as prime examples changes composition, particularly at phylum level, leads such diverse conditions inflammatory bowel (IBD), type 2 diabetes, psoriasis, Parkinson's disease, reflux oesophagitis others. The examines spatial understand dysbiosis gut particular can influence diseases distant sites via routes gut-lung, gut-skin gut-brain axes. Microbiome interaction with processes adaptive immunity increasingly identified critical developing capacity immune system react pathogens. essential bacteria involved modification substrates bile acid components result Crohn's small intestine overgrowth, hepatic cancer obesity. Interactions distantly located being identified, resulting 'whole body' effect combined microbiome.
Язык: Английский
Процитировано
111
Ageing Research Reviews, Год журнала: 2022, Номер 75, С. 101556 - 101556
Опубликована: Янв. 3, 2022
Alzheimer’s disease (AD) is the most common cause of dementia, accounting for more than 50 million patients worldwide. Current evidence suggests exact mechanism behind this devastating to be multifactorial origin, which seriously complicates quest an effective disease-modifying therapy, as well impedes search strategic preventative measures. Of interest, preclinical studies point serotonergic alterations, either induced via selective serotonin reuptake inhibitors or receptor (ant)agonists, in mitigating AD brain neuropathology next its clinical symptoms, latter being supported by a handful human intervention trials. Additionally, substantial amount trials highlight potential diet, fecal microbiota transplantations, pre- and probiotics modulating brain’s neurotransmitter system, starting from gut. Whether such interventions could truly prevent, reverse slow down progression likewise, should initially tested with mouse models, including sufficient analytical measurements both gut brain. Thereafter, therapeutic effect confirmed rigorously randomized controlled humans, preferentially across continuum, but especially prodromal up mild stages, where high adherence therapies, room noticeable enhancement are feasible still. In end, might aid development comprehensive approach tackle complex disease, since derivatives microbiota-gut-brain axis serve possible biomarkers progression, forming valuable target drug development. narrative review, available concerning orchestrating role within summarized discussed, general considerations future highlighted.
Язык: Английский
Процитировано
91
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Дек. 6, 2023
Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and nervous systems. In past few decades, breakthrough progress has been made in gut liver brain axis, mainly through understanding its formation mechanism increasing treatment strategies. this review, we discuss various complex networks including barrier permeability, hormones, microbial metabolites, vagus nerve, neurotransmitters, immunity, toxic β-amyloid (Aβ) metabolism, epigenetic regulation gut-liver-brain axis. Some therapies containing antibiotics, probiotics, prebiotics, synbiotics, fecal microbiota transplantation (FMT), polyphenols, low FODMAP diet nanotechnology application regulate Besides, some special treatments targeting gut-liver include farnesoid X receptor (FXR) agonists, takeda G protein-coupled 5 (TGR5) glucagon-like peptide-1 (GLP-1) antagonists fibroblast growth factor 19 (FGF19) analogs. Targeting gut-brain embraces cognitive behavioral therapy (CBT), antidepressants tryptophan metabolism-related therapies. liver-brain contains Aβ future, better interactions will promote development novel preventative strategies discovery precise therapeutic targets multiple diseases.
Язык: Английский
Процитировано
86