Frontiers in Microbiology,
Год журнала:
2021,
Номер
12
Опубликована: Ноя. 16, 2021
Caffeic
acid
(CA)
is
one
of
the
major
phenolic
acids
coffee
with
multiple
biological
activities.
Our
previous
study
found
that
500
mg/kg
chlorogenic
(CGA)
had
potential
capacity
alleviating
colonic
inflammation.
Moreover,
CGA
can
be
degraded
into
caffeic
by
gut
microbiota
in
colon.
Therefore,
we
hypothesize
CA
exert
protective
effects
on
To
test
hypothesis,
251
was
supplemented
to
DSS-induced
colitis
mice.
The
results
showed
treatment
recovered
disease
activity
index
(DAI),
colon
length,
and
histopathology
scores
tissue.
Additionally,
significantly
decreased
pro-inflammatory
cytokines
malondialdehyde
(MDA)
levels
increased
level
IL-10,
total
antioxidant
(T-AOC),
superoxide
dismutase
(SOD),
glutathione
peroxidase
(GSH-Px),
catalase
(CAT)
serum.
qPCR
indicated
dramatically
downregulated
mRNA
expression
IL-1β,
IL-6,
TNF-α
as
well
upregulated
SOD1,
GPX1,
GPX2,
CAT,
IL-10.
In
addition,
supplementation
Nrf-2,
HO-1,
NQO1,
which
its
anti-inflammatory
capacities
potentially
activating
Nrf-2/HO-1
pathway.
prevented
barrier
damage
enhancing
Occludin
gene
expression.
Furthermore,
altered
microbiome
composition
decreasing
relative
abundance
Bacteroides
Turicibacter,
Alistipes
Dubosiella.
Meanwhile,
increases
Dubosiella
Akkermansia.
conclusion,
could
effectively
alleviate
improving
defense
against
oxidative
stress
inflammatory
response.
Frontiers in Immunology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 6, 2023
Inflammatory
bowel
diseases,
including
Crohn's
disease
and
ulcerative
colitis,
is
a
chronic
relapsing
gastrointestinal
inflammatory
mediated
by
dysregulated
immune
responses
to
resident
intestinal
microbiota.
Current
conventional
approaches
aminosalicylates,
corticosteroids,
immunosuppressive
agents,
biological
therapies
are
focused
on
reducing
inflammation
besides
inducing
maintaining
remission,
managing
complications.
However,
these
not
curative
associated
with
various
limitations,
such
as
drug
resistance,
low
responsiveness
adverse
events.
Recent
accumulated
evidence
has
revealed
the
involvement
of
mucin-degrading
bacterium
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(25)
Опубликована: Апрель 13, 2023
Diabetic
wounds
are
characterized
by
drug-resistant
bacterial
infections,
biofilm
formation,
impaired
angiogenesis
and
perfusion,
oxidative
damage
to
the
microenvironment.
Given
their
complex
nature,
diabetic
remain
a
major
challenge
in
clinical
practice.
Reactive
oxygen
species
(ROS),
which
have
been
shown
trigger
hyperinflammation
excessive
cellular
apoptosis,
play
pivotal
role
pathogenesis
of
wounds.
ROS-scavenging
nanosystems
recently
emerged
as
smart
multifunctional
nanomedicines
with
broad
synergistic
applicability.
The
documented
anti-inflammatory
pro-angiogenic
ability
treatments
predestines
these
promising
options
for
treatment
Yet,
this
context,
therapeutic
applicability
efficacy
be
elucidated.
Herein,
ROS
is
deciphered,
properties
strengths
capacity
summarized.
In
addition,
current
challenges
such
potential
future
directions
discussed
through
clinical-translational
lens.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Окт. 9, 2023
Abstract
Individual
variability
in
drug
response
(IVDR)
can
be
a
major
cause
of
adverse
reactions
(ADRs)
and
prolonged
therapy,
resulting
substantial
health
economic
burden.
Despite
extensive
research
pharmacogenomics
regarding
the
impact
individual
genetic
background
on
pharmacokinetics
(PK)
pharmacodynamics
(PD),
diversity
explains
only
limited
proportion
IVDR.
The
role
gut
microbiota,
also
known
as
second
genome,
its
metabolites
modulating
therapeutic
outcomes
human
diseases
have
been
highlighted
by
recent
studies.
Consequently,
burgeoning
field
pharmacomicrobiomics
aims
to
explore
correlation
between
microbiota
variation
IVDR
or
ADRs.
This
review
presents
an
up-to-date
overview
intricate
interactions
classical
agents
for
systemic
diseases,
including
cancer,
cardiovascular
(CVDs),
endocrine
others.
We
summarise
how
directly
indirectly,
modify
absorption,
distribution,
metabolism,
excretion
(ADME)
drugs.
Conversely,
drugs
modulate
composition
function
leading
changes
microbial
metabolism
immune
response.
discuss
practical
challenges,
strategies,
opportunities
this
field,
emphasizing
critical
need
develop
innovative
approach
multi-omics,
integrate
various
data
types,
genomic
data,
well
translate
lab
into
clinical
practice.
To
sum
up,
represents
promising
avenue
address
improve
patient
outcomes,
further
is
imperative
unlock
full
potential
precision
medicine.
Abstract
High‐fat
diet
(HFD)
has
been
recognized
as
a
primary
factor
in
the
risk
of
chronic
disease.
Obesity,
diabetes,
gastrointestinal
diseases,
neurodegenerative
and
cardiovascular
diseases
have
long
known
with
high
worldwide
incidence.
In
this
review,
influences
gut
microbiota
their
corresponding
bacterial
metabolites
on
mechanisms
HFD‐induced
are
systematically
summarized.
Gut
imbalance
is
also
to
increase
susceptibility
diseases.
Several
studies
proven
that
HFD
negative
impact
microbiota,
exacerbating
course
many
through
increased
populations
Erysipelotrichaceae
,
facultative
anaerobic
bacteria,
opportunistic
pathogens.
Since
bile
acids,
lipopolysaccharide,
short‐chain
fatty
trimethylamine
N
‐oxide
common
features
metabolites,
we
will
explore
possibility
synergistic
among
those
context
Recent
literature
concerning
mechanistic
actions
HFD‐mediated
collected
from
PubMed,
Google
Scholar,
Scopus.
The
aim
review
provide
new
insights
into
point
out
potential
biomarkers
microbiota.
Inflammation-associated
insulin
resistance
is
a
key
trigger
of
gestational
diabetes
mellitus
(GDM),
but
the
underlying
mechanisms
and
effective
interventions
remain
unclear.
Here,
we
report
association
placental
inflammation
(tumor
necrosis
factor–α)
abnormal
maternal
glucose
metabolism
in
patients
with
GDM,
high
fermentable
dietary
fiber
(HFDF;
konjac
)
could
reduce
GDM
development
through
gut
flora–short-chain
fatty
acid–placental
axis
mouse
model.
Mechanistically,
HFDF
increases
abundances
Lachnospiraceae
butyrate,
reduces
placental-derived
by
enhancing
barrier
inhibiting
transfer
bacterial-derived
lipopolysaccharide,
ultimately
resists
high-fat
diet–induced
resistance.
butyrate
have
similar
anti-GDM
anti–placental
effects,
they
can
ameliorate
function
pregnancy
outcome
effects
probably
dampening
immune
dysfunction.
These
findings
demonstrate
involvement
important
inflammation–related
progression
great
potential
HFDFs
to
susceptibility
gut-flora-placenta
axis.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 14, 2024
Recent
studies
have
indicated
that
gut
microbiota-mediated
oxidative
stress
is
significantly
associated
with
intestinal
diseases
such
as
colorectal
cancer,
ulcerative
colitis,
and
Crohn’s
disease.
The
level
of
reactive
oxygen
species
(ROS)
has
been
reported
to
increase
when
the
microbiota
dysregulated,
especially
several
bacterial
metabolites
are
present.
Although
healthy
plays
a
vital
role
in
defending
against
excessive
stress,
disease
influenced
by
ROS,
this
process
controlled
immunological
responses,
DNA
damage,
inflammation.
In
review,
we
discuss
relationship
between
from
an
perspective.
addition,
also
provide
summary
most
recent
therapeutic
approaches
for
preventing
or
treating
modifying
microbiota.
