Problems of Biological Medical and Pharmaceutical Chemistry,
Год журнала:
2024,
Номер
27(2), С. 15 - 22
Опубликована: Фев. 2, 2024
Introduction.
Coronary
heart
disease
(CHD),
leading
among
the
causes
of
death
in
adulthood
and
old
age,
is
an
urgent
medical
social
problem.
The
pathogenesis
most
forms
coronary
based
on
stenosing
atherosclerosis
arteries,
which
develops
against
background
dyslipidemia
arterial
hypertension
accompanied
by
activation
immunocompetent
cells
(ICCs)
vascular
wall
with
development
a
subclinical
inflammatory
reaction,
as
well
production
pro-inflammatory
factors
such
interleukins,
chemokines,
growth
etc.
In
turn,
ICC
activity
determined
state
their
intracellular
molecular
cascades,
transmit
signals
into
cell
ensure
its
reactivity
to
various
external
stimuli,
mitogens,
cytokines,
pathogen
components,
etcIt
has
been
shown
that
central
nervous
system
plays
important
role
regulation
due
neurohumoral
molecules,
melatonin,
endorphin,
sero-tonin,
etc.,
coordination
immune
responses
control
system.
aim
this
study
was
relationship
between
melatonin
regulate
activi-ty
whole
blood
mononuclear
metabolism
patients
artery
disease.
Material
methods.
As
part
cohort
study,
58
both
sexes
aged
49
67
years
20
practically
healthy
individuals
were
examined.
accordance
purpose
concentration
focal
adhesion
protein
kinase
(FAK),
5'AMP-activated
(AMPK),
AKT1
kinase,
signal
transducers
transcription
activators
(STAT)
nuclear
cy-toplasmic
lysates
cells:
STAT3,
STAT5A
STAT6,
c-Jun
N-terminal
1
2
isoforms
(JNK),
mitogen-activated
p38
(p38),
extracellular
(ERK),
Janus
type
(JAK2),
factor
NF
-kB,
caspase-1,
cyclooxygenase-2
(COX-2),
p70-S6K1
p53,
p27,
p21
proteins.
addition,
cyclic
adenosine
monophos-phate
(cAMP)
guanosine
monophosphate
(cGMP)
supernatants.
Melatonin
se-rum.
material
for
venous
taken
from
cubital
vein
morning
6.00
6.15.
Results.
analysis
showed
disease,
comparison
individuals,
MNCs
blood,
there
increased
level
kinases
FAK,
AKT,
JNK,
ERK,
p70-S6K1,
p21,
decrease
content
STAT5A,
JAK2,
NF-kB
caspase-1.
These
changes
levels
cGMP
cAMP.
Against
background,
revealed
MNC.
A
high
CAD
as-sociated
AMPK,
Jak2,
ERK1,
cAMP
MNCs,
observed
increase
p27
NF-kB.
results
correlation
indicate
different
na-ture
protein,
depending
characteristics
Conclusions.
exhibits
modulating
effect
energy
balance
ICCs
metabolism,
helps
limit
limiting
functional
MAPK/SAPK
signaling
pathways
MNCs.
Melatonin,
N-acetyl-5-methoxytryptamine,
is
a
neuroendocrine
hormone
secreted
by
the
pineal
gland.
This
pleiotropic
indoleamine
possesses
amphiphilic
properties,
allowing
it
to
penetrate
most
biological
barriers
and
exert
its
effects
at
subcellular
level.
Importantly,
melatonin
also
plays
crucial
role
in
regulating
body's
response
circadian
rhythms,
adapting
internal
external
environmental
cues.
Melatonin
functions
as
powerful
antioxidant
free
radical
scavenger,
protecting
cells
from
oxidative
damage.
Its
diverse
physiological
roles
include
maintaining
functional
integrity
of
endothelial
cells,
thereby
preventing
atherosclerosis,
major
contributor
cardiovascular
disease.
Additionally,
exhibits
scavenging
potentially
improving
metabolic
disorders.
These
combined
suggest
unique
adjunctive
therapeutic
potential
for
treating
diseases.
review
aims
explore
mechanisms
which
interacts
with
system
investigates
use
an
agent
managing
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Май 13, 2022
Mitochondria,
the
intracellular
organelles
for
cellular
aerobic
respiration
and
energy
production,
play
an
important
role
in
regulation
of
cell
metabolism
fate.
Mitophagy,
a
selective
form
autophagy,
maintains
dynamic
homeostasis
cells
through
targeting
long-lived
or
defective
mitochondria
timely
clearance
recycling.
Dysfunction
mitophagy
is
involved
molecular
mechanism
responsible
onset
development
human
diseases.
FUN14
domain
containing
1
(FUNDC1)
mitochondrial
receptor
located
outer
membrane
(OMM)
to
govern
process.
Emerging
evidence
has
demonstrated
that
levels
phosphorylation
states
FUNDC1
are
closely
related
occurrence,
progression
prognosis
cardiovascular
diseases,
indicating
novel
this
system.
Here
we
review
mediated
by
its
various
forms
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 14, 2024
Abstract
Background
Chimeric
antigen
receptor
CAR-T
cell
therapies
have
ushered
in
a
new
era
of
treatment
for
specific
blood
cancers,
offering
unparalleled
efficacy
cases
resistance
or
relapse.
However,
the
emergence
cytokine
release
syndrome
(CRS)
as
side
effect
poses
challenge
to
widespread
application
therapies.
Melatonin,
natural
hormone
produced
by
pineal
gland
known
its
antioxidant
and
anti-inflammatory
properties,
has
been
explored
potential
immunomodulatory
effects.
Despite
this,
role
mitigating
cell-induced
CRS
remains
poorly
understood.
Methods
In
this
study,
our
aim
was
investigate
melatonin
an
agent
context
CD19-targeting
therapy
impact
on
associated
Using
mouse
model,
we
evaluated
effects
overall
survival.
Additionally,
assessed
whether
administration
had
any
detrimental
antitumor
persistence
CD19
cells.
Results
Our
findings
demonstrate
that
effectively
mitigated
severity
leading
improved
survival
outcomes.
Remarkably,
did
not
compromise
effectiveness
cells,
indicating
compatibility
with
therapeutic
goals.
These
results
suggest
melatonin's
compound
alleviate
without
compromising
benefits
therapy.
Conclusion
The
study's
outcomes
shed
light
promise
valuable
addition
existing
protocols
By
attenuating
while
preserving
offers
strategy
optimizing
refining
safety
profile
This
research
contributes
evolving
understanding
how
harness
agents
enhance
clinical
innovative
cancer
treatments.
Pharmaceutics,
Год журнала:
2022,
Номер
14(12), С. 2760 - 2760
Опубликована: Дек. 9, 2022
Cardiovascular
disease
(CVD)
is
a
group
of
systemic
disorders
threatening
human
health
with
complex
pathogenesis,
among
which
mitochondrial
energy
metabolism
reprogramming
has
critical
role.
Mitochondria
are
cell
organelles
that
fuel
the
essential
for
biochemical
reactions
and
maintain
normal
physiological
functions
body.
Mitochondrial
metabolic
extensively
involved
in
progression
CVD,
especially
energy-demanding
organs
such
as
heart.
Therefore,
elucidating
role
CVD
great
significance
to
further
understand
pathogenesis
explore
preventive
therapeutic
methods.
In
this
review,
we
discuss
major
factors
their
potential
roles
prevention
treatment
CVD.
The
current
application
mitochondria-targeted
agents
advances
gene
therapy
technologies
also
overviewed.
Heliyon,
Год журнала:
2023,
Номер
9(6), С. e16735 - e16735
Опубликована: Май 30, 2023
Mammalian
infertile-20-like
kinase
4
(MST4)
plays
major
roles
in
the
progression
of
malignant
tumor
types,
but
its
function
gastric
cancer
(GC)
remains
poorly
understood.To
investigate
regulatory
mechanism
MST4
GC.Immunohistochemistry
was
used
to
detect
protein
GC
tissue.
Additionally,
correlation
between
expression
and
clinicopathological
characteristics
prognosis
evaluated.
The
level
cells
measured
by
western
blotting
quantitative
real-time
polymerase
chain
reaction.
Moreover,
investigated
vitro
vivo.Overexpression
found
tissue
cell
lines,
which
correlated
size,
histological
type,
invasion
depth,
ulcer,
lymph
node
metastasis,
lymphovascular
invasion,
perineural
TNM
stage
(all
P
<
0.01).
In
terms
functions
vitro,
upregulation
facilitated
proliferation,
migration,
cells.
Furthermore,
promoted
these
processes
facilitating
autophagy,
whereas
downregulation
significantly
attenuated
processes.
Downregulation
also
growth
vivo.High
indicates
a
poor
promotes
metastasis
enhancing
autophagy.
Molecules,
Год журнала:
2022,
Номер
27(15), С. 4888 - 4888
Опубликована: Июль 30, 2022
Psychoneuroendocrinoimmunology
is
the
area
of
study
intimate
relationship
between
immune,
physical,
emotional,
and
psychological
aspects.
This
new
way
studying
human
body
its
diseases
was
initiated
in
last
century’s
first
decades.
However,
molecules
that
participate
communication
endocrine,
neurological
systems
are
still
being
discovered.
paper
aims
to
describe
development
psychoneuroendocrinoimmunology,
scopes,
limitations
actual
medicine,
extent
melatonin
within
it.
