Curcumin Mitigates the High-Fat High-Sugar Diet-Induced Impairment of Spatial Memory, Hepatic Metabolism, and the Alteration of the Gut Microbiome in Alzheimer’s Disease-Induced (3xTg-AD) Mice

Nutrients, Год журнала: 2024, Номер 16(2), С. 240 - 240

Опубликована: Янв. 12, 2024

The escalating prevalence of metabolic diseases and an aging demographic has been correlated with a concerning rise in Alzheimer's disease (AD) incidence. This study aimed to access the protective effects curcumin, bioactive flavonoid from turmeric, on spatial memory, functions, regulation gut microbiome AD-induced (3xTg-AD) mice fed either normal chow diet (NCD) or high-fat high-sugar (HFHSD). Our findings revealed augmented susceptibility HFHSD-fed 3xTg-AD for weight gain memory impairment, while curcumin supplementation demonstrated effect against these changes. was evidenced by significantly reduced body improved behavioral cognitive function curcumin-treated group. These improvements were substantiated diminished fatty acid synthesis, altered cholesterol metabolism, suppressed adipogenesis-related pathways liver, along modified synaptic plasticity-related brain. Moreover, enriched beneficial microbiota, including

Язык: Английский

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Investigating causal associations among gut microbiota, metabolites, and liver diseases: a Mendelian randomization study

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Июль 5, 2023

Objective There is some evidence for an association between gut microbiota and nonalcoholic fatty liver disease (NAFLD), alcoholic (ALD), viral hepatitis, but no studies have explored their causal relationship. Methods Instrumental variables of the (N = 13266) microbiota-derived metabolites 7824) were acquired, a Mendelian randomization study was performed to explore influence on NAFLD (1483 European cases 17,781 controls), ALD (2513 332,951 hepatitis risk (1971 340,528 controls). The main method examining causality inverse variance weighting (IVW). Results IVW results confirmed that Anaerotruncus ( p 0.0249), Intestinimonas 0.0237), Lachnoclostridium 0.0245), Lachnospiraceae NC2004 group 0.0083), Olsenella 0.0163), Peptococcus 0.0472) protective factors NAFLD, Ruminococcus 1 0.0120) detrimental NAFLD. higher abundance three genera, Lachnospira 0.0388), Desulfovibrio 0.0252), torques 0.0364), correlated with lower ALD, while Ruminococcaceae UCG 002 level associated 0.0371). Alistipes 0.0069) NK4A214 0.0195) related hepatitis. Besides, alanine 0.0076) phenyllactate 0.0100) found be negatively stachydrine (O 0.0244) positively phenylacetate 0.0353) ursodeoxycholate 0.0144) had effect threonate 0.0370) exerted ALD. estimates 0.0408) cholate 0.0293) showed suggestive harmful effects against 0.0401) displayed its Conclusion In conclusion, our research supported links microbiome

Язык: Английский

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Composition of gut microbiota and non‐alcoholic fatty liver disease: A systematic review and meta‐analysis

Obesity Reviews, Год журнала: 2023, Номер 25(1)

Опубликована: Окт. 9, 2023

Summary The present systematic review and meta‐analysis aimed to summarize the associations between gut microbiota composition non‐alcoholic fatty liver disease. To compare differences individuals with or without NAFLD, standardized mean difference 95% confidence interval were computed for each α‐diversity index relative abundance of microbes. β‐diversity indices summarized in a qualitative manner. A total 54 studies 8894 participants included. Overall, patients NAFLD had moderate reduction including Shannon (SMD = −0.36, CI [−0.53, −0.19], p < 0.001) Chao 1 −0.42, [−0.68, −0.17], 0.001), but no significant found Simpson, observed species, phylogenetic diversity, richness, abundance‐based coverage estimator, evenness ( ranged from 0.081 0.953). Over 75% included reported β‐diversity. Although there was substantial interstudy heterogeneity, especially analyses at phylum, class, family levels, majority showed alterations depletion anti‐inflammatory microbes (i.e., Ruminococcaceae Coprococcus ) enrichment proinflammatory Fusobacterium Escherichia NAFLD. Perturbations associated commonly reflected by beneficial species an increase pathogenic species.

Язык: Английский

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Association between Gut Microbiota and Digestive System Cancers: A Bidirectional Two-Sample Mendelian Randomization Study

Nutrients, Год журнала: 2023, Номер 15(13), С. 2937 - 2937

Опубликована: Июнь 28, 2023

Accumulating evidence indicates that gut microbiota closely correlates with the tumorigenesis of digestive system cancers (DSCs). However, whether causality between and DSCs exists is unknown. Genome-wide association study (GWAS) summary statistics for bidirectional two-sample Mendelian randomization (MR) analysis were utilized to assess DSCs. Sensitivity analyses performed evaluate robustness our results. We found genus Eggerthella (OR = 0.464, 95%CI: 0.27 0.796, p 0.005) was negatively associated risk gastric cancer. The genetically predicted Lachnospiraceae FCS020 group 0.607, 0.439 0.84, 0.003) correlated a lower colorectal cancer, Turicibacter 0.271, 0.109 0.676, protective factor liver In reverse MR, regulated relative abundance specific strains microbiota. comprehensively screened using MR identified several microbial taxa Our discoveries are beneficial development novel markers microbiota-modifying therapeutics DSC patients.

Язык: Английский

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Gut microbiome features and metabolites in non-alcoholic fatty liver disease among community-dwelling middle-aged and older adults

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Март 7, 2024

Abstract Background The specific microbiota and associated metabolites linked to non-alcoholic fatty liver disease (NAFLD) are still controversial. Thus, we aimed understand how the core gut impact NAFLD. Methods data for discovery cohort were collected from Guangzhou Nutrition Health Study (GNHS) follow-up conducted between 2014 2018. We 272 metadata points 1546 individuals. input into four interpretable machine learning models identify important with These subsequently applied two validation cohorts [the internal ( n = 377), prospective 749)] assess generalizability. constructed an individual microbiome risk score (MRS) based on identified animal faecal transplantation experiment using samples individuals different levels of MRS determine relationship Additionally, targeted metabolomic sequencing analyse potential metabolites. Results Among used, lightGBM algorithm achieved best performance. A total 12 taxa-related features selected by further used calculate MRS. Increased was positively presence NAFLD, odds ratio (OR) 1.86 (1.72, 2.02) per 1-unit increase in An elevated abundance f__veillonellaceae ) increased NAFLD risk, whereas f__rikenellaceae , f__barnesiellaceae s__adolescentis a decreased Higher microbiota-derived bile acids (taurocholic acid) might be both higher risk. FMT mice confirmed causal association development Conclusions that alteration composition biologically relevant development. Our work demonstrated role

Язык: Английский

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Polysaccharide from Panax japonicus C.A. Mey prevents non-alcoholic fatty liver disease development based on regulating liver metabolism and gut microbiota in mice

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129430 - 129430

Опубликована: Янв. 18, 2024

Язык: Английский

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Alteration of Gut Microbiota Composition in the Progression of Liver Damage in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4387 - 4387

Опубликована: Апрель 16, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex disorder whose prevalence rapidly growing in South America. The disturbances the microbiota–gut–liver axis impact damaging processes toward fibrosis. Gut microbiota status shaped by dietary and lifestyle factors, depending on geographic location. We aimed to identify microbial signatures group of Chilean MASLD patients. Forty subjects were recruited, including healthy controls (HCs), overweight/obese (Ow/Ob), patients with without fibrosis (MASLD/F−), (MASLD/F+). Both detected through elastography and/or biopsy, fecal analyzed deep sequencing. Despite no differences α- β-diversity among all groups, higher abundance Bilophila lower presence Defluviitaleaceae, Lachnospiraceae ND3007, Coprobacter was found MASLD/F− MASLD/F+, compared HC. Ruminococcaceae UCG-013 Sellimonas more abundant MASLD/F+ than Ow/Ob; both significantly differed between Significant positive correlations observed stiffness Bifidobacterium, Prevotella, Sarcina, Acidaminococcus abundance. Our results show that associated changes bacterial taxa are known be involved bile acid metabolism SCFA production, some them being specifically linked

Язык: Английский

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Chronic exposure to parabens promotes non-alcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism

Food & Function, Год журнала: 2024, Номер 15(3), С. 1562 - 1574

Опубликована: Янв. 1, 2024

Non-alcoholic fatty liver disease (NAFLD) has become a serious public health issue due to changing dietary patterns and composition. However, the relationship between NAFLD occurrence food additives, such as preservatives, remains unknown. This study aimed evaluate toxicity of parabens, namely methylparaben (MeP) ethylparaben (EtP), in relation mice under different conditions. Exposure MeP EtP exacerbated high-fat diet (HFD)-induced obesity, glucose intolerance, higher serum lipid concentrations, fat accumulation by upregulating genes involved metabolism. Untargeted metabolomics revealed that arachidonic acid (AA) metabolism was top enriched pathway upon exposure presence HFD. 11,12-Epoxyeicosatrienoic (11,12-EET) most abundant AA metabolite significantly reduced or EtP. Moreover, an integrative analysis differential fecal taxa at genus level metabolites significant associations. In addition, enhanced AML12 cells HepG2 cultured with oleic acid. 11,12-EET supplementation could alleviate suppressing expression metabolism-related proteins. The present suggests chronic promoted

Язык: Английский

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Aqueous extract of Polygala japonica Houtt. ameliorated nonalcoholic steatohepatitis in mice through restoring the gut microbiota disorders and affecting the metabolites in feces and liver

Phytomedicine, Год журнала: 2023, Номер 118, С. 154937 - 154937

Опубликована: Июнь 21, 2023

Polygala japonica Houtt. (PJ) has been demonstrated with several biological potentials such as lipid-lowering and anti-inflammatory effects. However, the effects mechanisms of PJ on nonalcoholic steatohepatitis (NASH) remain unclear.The aim this study was to evaluate NASH illustrate mechanism based modulating gut microbiota host metabolism.NASH mouse model induced using methionine choline deficient (MCD) diet orally treated PJ. The therapeutic, anti-inflammatory, anti-oxidative mice were firstly assessed. Then, analyzed 16S rRNA sequencing assess changes. Finally, metabolites in liver feces explored by untargeted metabolomics.The results indicated that could improve hepatic steatosis, injury, inflammatory response, oxidative stress mice. treatment also affected diversity changed relative abundances Faecalibaculum. Lactobacillus, Muribaculaceae, Dubosiella, Akkermansia, Lachnospiraceae_NK4A136_group, Turicibacter In addition, modulated 59 both feces. Metabolites involved histidine, tryptophan metabolism pathways identified key according correlation analysis between differential metabolites.Our NASH. related improvement dysbiosis regulation histidine metabolism.

Язык: Английский

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Involvement of intestinal mucosal microbiota in adenine-induced liver function injury

3 Biotech, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 12, 2024

Язык: Английский

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