The role of MAPK pathway in gastric cancer: unveiling molecular crosstalk and therapeutic prospects DOI Creative Commons
Weiwei Yuan, Shi Yin,

Shiping Dai

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 24, 2024

Gastric cancer remains a significant health burden globally, especially prevalent in Asian and European regions. Despite notable decline incidence the United States Western Europe over recent decades, disease's persistence underscores urgency for advanced research its pathogenesis treatment strategies. Central to this pursuit is exploration of mitogen-activated protein kinase (MAPK) pathway, pivotal cellular mechanism implicated complex processes gastric development, including proliferation, invasion, migration, metastasis. The MAPK or extracellular signal-regulated pathway serves as crucial conduit transmitting signals elicit intracellular responses, with signaling cascades subject alterations due genetic epigenetic variations across various diseases, prominently cancer. This review delves into intricate role cancer, drawing upon most critical studies that shed light on gateway disease. It highlights pathway's involvement Helicobacter pylori-mediated carcinogenesis tumorigenic induced by Epstein-Barr virus, showcasing substantial influence miRNAs lncRNAs modulating cancer's biological properties through their interaction pathway. Furthermore, extends therapeutic arena, discussing promising impacts herbal medicines, inhibitors, immunosuppressants mitigating progression. Through an exhaustive examination multifaceted from molecular crosstalks prospects, aspires contribute ongoing efforts understanding combating global challenge, paving way novel interventions improved patient outcomes.

Language: Английский

Helicobacter pylori infection: a dynamic process from diagnosis to treatment DOI Creative Commons

Qifang Sun,

Chengzhi Yuan,

Sainan Zhou

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Oct. 19, 2023

, a gram-negative microaerophilic pathogen, causes several upper gastrointestinal diseases, such as chronic gastritis, peptic ulcer disease, and gastric cancer. For the diseases listed above,

Language: Английский

Citations

47
Polyphenol-Loaded Nano-carriers for Breast Cancer Therapy: A Comprehensive Review DOI
Asif Ahmad Bhat, Gaurav Gupta, Muhammad Afzal

et al.

BioNanoScience, Journal Year: 2024, Volume and Issue: 14(4), P. 4219 - 4237

Published: Jan. 10, 2024

Language: Английский

Citations

21
Reshaping the immune microenvironment and reversing immunosenescence by natural products: prospects for immunotherapy in gastric cancer DOI
Zhipeng Cao, Zhilin Wang, Yang Li

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: 110, P. 1 - 16

Published: Feb. 8, 2025

Language: Английский

Citations

4
Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression DOI

Leiguang Ye,

Yingpu Li, Sifan Zhang

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2023, Volume and Issue: 73, P. 27 - 39

Published: May 24, 2023

Language: Английский

Citations

34
A review of signal pathway induced by virulent protein CagA of Helicobacter pylori DOI Creative Commons
Hai‐Qiang Wang,

Mei Zhao,

Fan Shi

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: April 14, 2023

Gastric cancer (GC), a common and high-mortality disease, still occupies an important position in current research, Helicobacter pylori ( H. ) infection as its risk factor has been hot challenging research area. Among the numerous pathogenic factors of , virulence protein CagA widely studied only bacterial-derived oncoprotein. It was found that entering into gastric epithelial cells (GECs) can induce dysregulation multiple cellular pathways such MAPK signaling pathway, PI3K/Akt NF-κB Wnt/β-catenin JAK-STAT Hippo pathway through phosphorylation non-phosphorylation. These disordered cause pathological changes morphology, adhesion, polarity, proliferation, movement, other processes GECs, which eventually promotes occurrence GC. With deepening -related on CagA-induced abnormal updated deepened to some extent, so key activated by are used main stem sort out pathogenesis this paper, aiming provide new strategies for treatment GC future.

Language: Английский

Citations

29
Effect of Helicobacter pylori eradication on gastric precancerous lesions: A systematic review and meta‐analysis DOI Creative Commons
Fangyuan Zhu,

Xiao-Ze Zhang,

Ping Li

et al.

Helicobacter, Journal Year: 2023, Volume and Issue: 28(6)

Published: Aug. 21, 2023

Abstract Background The question of whether eradication Helicobacter pylori (Hp) can reverse gastric precancerous lesions, including intestinal metaplasia, remains uncertain, leading to ongoing debate. Therefore, a meta‐analysis was performed evaluate the effect Hp on lesions. Materials and Methods PubMed, Embase, Cochrane Library, Web Science, Scopus database, ClinicalTrials.gov were systematically searched from inception April 2023 for studies that explored impact Risk ratios (RRs) their 95% confidence intervals (95% CIs) selected as size. We used random‐effects model assess pooled data. also quality assessments, subgroup analyses, sensitivity analyses. Results Fifteen included. Compared with placebo, could significantly prevent progression lesions (RR = 0.87, CI: 0.81–0.94, p < 0.01) them 1.32, 1.17–1.50, 0.01). Then, specific further explored. metaplasia prevented by compared placebo or no treatment 0.80, 0.69–0.94, Moreover, treatment, improved chronic atrophic gastritis 1.84, 1.30–2.61, 1.41, 1.15–1.73, However, in terms preventing dysplasia 0.86, 0.37–2.00) improving 0.89, 0.47–1.70), had advantage treatment. Conclusions therapy them. Notably, be reversed, but this may only appropriate patients epigenetic alterations milder

Language: Английский

Citations

26
Berberine alleviates neuroinflammation by downregulating NFκB/LCN2 pathway in sepsis-associated encephalopathy: network pharmacology, bioinformatics, and experimental validation DOI
Hailong Gong, Yun Xia, Guoqing Jing

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 133, P. 112036 - 112036

Published: April 18, 2024

Language: Английский

Citations

10
Traditional Chinese medicine for chronic atrophic gastritis: Efficacy, mechanisms and targets DOI
Li Wang,

Yan-Jie Lian,

Jingjing Dong

et al.

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(9)

Published: Feb. 18, 2025

Chronic atrophic gastritis (CAG) is an important stage of precancerous lesions gastric cancer. Effective treatment and regulation CAG are essential to prevent its progression malignancy. Traditional Chinese medicine (TCM) has shown multi-targeted efficacy in treatment, with advantages enhancing mucosal barrier defense, improving microcirculation, modulating inflammatory immune responses, promoting lesion healing, etc. Clinical studies meta-analyses indicate that TCM provides significant benefits, specific herbal compounds monomers demonstrating protective effects on the mucosa through mechanisms including anti-inflammation, anti-oxidation, cellular proliferation apoptosis, Finally, it pointed out requires standardized research unified standards, constantly clarifies improves evaluation criteria each dimension function.

Language: Английский

Citations

2
Potential mechanism of traditional Chinese medicine intervention in gastric cancer: targeted regulation of autophagy DOI Creative Commons

Siyuan Sun,

Wenqian Yu,

Guangheng Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 18, 2025

Gastric cancer (GC) is a prevalent malignant tumor that originates from the epithelial cells of gastric mucosa, predominantly in form adenocarcinoma. Extensive research has confirmed significant role autophagy initiation, progression, and chemoresistance GC. The potential traditional Chinese medicine (TCM) to exert anti-tumor effects by modulating been demonstrated, particularly context GC prevention treatment. Natural products (NPs) have great therapeutic treatment targeting autophagy-related genes signaling pathways intervene biological behaviors such as proliferation, metastasis, invasion death. This article describes molecular mechanisms key markers autophagy, involved GC-associated (PI3K/AKT/mTOR, AMPK, MAPK, p53), summarizes mechanism Helicobacter pylori infection GC, how interacts with apoptotic iron-death processes wide-ranging influences these factors play process. Finally, this paper systematically natural compounds terpenoids, polyphenols, alkaloids, saponins, polysaccharides modulate targets for evaluates toxic NPs, providing more compelling rationale direction therapy.

Language: Английский

Citations

2
Emerging trends and research foci of berberine on tumor from 2002 to 2021: A bibliometric article of the literature from WoSCC DOI Creative Commons

Runzhu Yuan,

Yao Tan, Ping‐Hui Sun

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 3, 2023

Background: Cancer, also known as a malignant tumor, is caused by the activation of oncogenes, which leads to uncontrolled proliferation cells that results in swelling. According World Health Organization (WHO), cancer one main causes death worldwide. The variables limiting efficacy anti-tumor treatments are side effects and drug resistance. search for natural, safe, low toxicity, efficient chemical compounds tumor research essential. Berberine pentacyclic isoquinoline quaternary ammonium alkaloid isolated from Berberis Coptis has long been used clinical settings. Studies recent years have reported use berberine treatment. In this study, we performed bibliometric analysis berberine- tumor-related research. Materials methods: Relevant articles January 1, 2002, December 31, 2021, were identified Web Science Core Collection (WOSCC) Clarivate Analytics. Microsoft Excel, CiteSpace, VOSviewer, an online platform literary metrology analysis. Results: A total 1368 publications had unique characteristics. Publications China most common (783 articles), Y. B. Feng (from China) was productive author, with highest citations. Medical University (Taiwan) Sun Yat-sen (China) two organizations largest numbers (36 each). Frontiers Pharmacology commonly occurring journal (29 articles). present body focused on mechanism, molecular docking, oxidative stress tumors. Conclusion: Research tumors thoroughly reviewed using knowledge map methods. study reveal dynamic evolution provide basis strategic planning

Language: Английский

Citations

22