Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 281 - 281
Опубликована: Фев. 27, 2025
Ilex
rotunda,
an
evergreen
tree
in
the
holly
family,
is
a
traditional
medicine
with
high
phenolic
content
and
various
pharmacological
effects.
This
study
aimed
to
investigate
constituents
from
enriched
fractions
guided
by
total
assay
along
feature-based
molecular
network.
Nine
compounds
were
isolated
identified
using
multiple
chromatography
spectroscopic
techniques.
These
isolates
exhibited
significantly
antioxidative
effects
both
free
radical
scavenging
ROS
assays.
They
also
remarkedly
alternated
interleukin
(IL)-2
production
CD3/CD28-stimulated
Jurkat
T
cells.
The
Western
blotting
suggested
that
these
active
might
decrease
IL-2
blocking
activation
of
NF-κB
MAPK
signaling
pathways
downregulating
phosphorylation
p38
p65
proteins
as
well
ERK
JNK
kinases.
Molecular
docking
data
confirmed
above-mentioned
biological
properties
those
evaluating
their
binding
affinities
for
target
proteins.
Our
findings
offer
guidance
assessing
potential
chemicals
I.
rotunda
products
improve
oxidative
stress
enhance
immune
response
more
in-depth
studies.
Pharmaceutics,
Год журнала:
2023,
Номер
15(9), С. 2361 - 2361
Опубликована: Сен. 21, 2023
Nanoformulations
have
become
increasingly
useful
as
drug
delivery
technologies
in
recent
decades.
As
therapeutics,
oral
administration
is
the
most
common
method,
although
it
not
always
effective
route
because
of
challenges
with
swallowing,
gastrointestinal
discomfort,
low
solubility,
and
poor
absorption.
One
significant
barriers
that
medications
must
overcome
to
exert
a
therapeutic
effect
impact
first
hepatic
transit.
Studies
shown
controlled-release
systems
using
nanoparticles
composed
biodegradable
natural
polymers
significantly
improve
administration,
which
why
these
materials
attracted
attention.
Chitosan
possesses
wide
variety
properties
functions
pharmaceutical
well
healthcare
industries.
Drug
encapsulation
transport
within
body
are
two
its
important
features.
Moreover,
chitosan
can
enhance
efficacy
by
facilitating
interaction
target
cells.
Based
on
physicochemical
properties,
potentially
be
synthesized
into
nanoparticles,
this
review
summarizes
advances
applications
orally
delivered
nanoparticle
interventions.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 209 - 209
Опубликована: Фев. 4, 2025
This
study
conducted
a
literature
review
by
searching
for
articles
related
to
the
treatment
of
skin
infections/wrinkles
using
nano-delivery
systems
containing
natural
compounds.
The
search
was
in
various
databases
published
last
10
years,
with
strict
inclusion
and
exclusion
criteria.
Of
490
found,
40
were
considered
relevant.
Acne
vulgaris
is
common
dermatological
disorder
characterised
inflammation
sebaceous
glands,
often
resulting
development
pimples,
cysts,
scarring.
Conventional
treatments,
including
antibiotics
topical
retinoids,
frequently
demonstrate
limitations
such
as
side
effects,
resistance,
insufficient
absorption.
Recent
advancements
nanotechnology
have
enabled
creation
innovative
drug-delivery
that
enhance
effectiveness
reduce
adverse
effects
anti-acne
medications.
Polyphenols
flavonoids,
bioactive
compounds
notable
anti-inflammatory,
antioxidant,
antibacterial
properties,
are
recognised
their
therapeutic
acne
treatment.
However,
practical
application
hindered
solubility,
stability,
bioavailability.
incorporation
these
into
nanoparticle-based
delivery
has
shown
promise
resolving
challenges.
Various
nanoparticle
platforms,
lipid-based
nanoparticles,
polymeric
solid
lipid
evaluated
ability
improve
controlled
release,
targeted
polyphenols
flavonoids
skin.
advent
polyphenol
flavonoid-loaded
nanoparticles
marks
new
therapy
era.
LWT,
Год журнала:
2024,
Номер
197, С. 115931 - 115931
Опубликована: Март 1, 2024
Microbial
fermentation,
a
widely
used
food
processing
technology,
enhanced
the
biological
activity
and
nutritional
profile
of
raw
materials.
The
impact
fermentation
by
Bifidobacterium
adolescentis
Monascus
purpureus
on
functional
components
antioxidant
ginger
was
investigated.
results
showed
that
fermented
two
strains
notably
increased
content
gingerol,
total
flavonoids,
polyphenols,
its
capacity
as
measured
various
assays
such
DPPH,
ABTS,
FRAP.
active
were
superior
in
M.
compared
to
B.
adolescentis.
comparison
organic
acid
demonstrated
lactic
succinic
adolescentis,
while
acetic
acid,
fumaric
citric
purpureus.
Pearson
correlation
analysis
positive
relation
between
pigments,
Monacolin
K,
capacity.
Therefore,
has
potential
enhance
ginger.
This
study
might
have
implications
for
development
ginger-based
products
theoretical
basis
deep
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Янв. 27, 2024
Abstract
Tomato
pomace
(TP),
an
antioxidant-rich
byproduct,
may
be
suitable
for
noble
applications.
The
regulation
of
ROS
generation
and
the
anti-inflammatory
response
can
help
to
prevent
ulceration.
purpose
this
study
was
examine
TP
antioxidants,
in
silico
properties,
its
potential
protect
against
ulceration
erosion
triggered
by
indomethacin.
extract
(TPE)
encapsulated
either
alone
or
with
probiotics
maximize
effect.
These
microcapsules
were
investigated
indomethacin-treated
rats.
TPE
demonstrated
antioxidant
activity
as
well
high
levels
carotenoids
(15
mg/g
extract)
polyphenols.
Because
their
binding
affinity
hydrophobic
hydrogen
bond
interactions
active
sites
TNF-α
IL-1β
inflammatory
cytokines,
ellagic
acid
rutin
implicated
effect
TPE,
according
docking
study.
microcapsules,
combination
probiotics,
a
protective
enterocolitis
reducing
oxidative
stress
inflammation,
evidenced
decrease
stomach
intestinal
MDA,
NO,
IL-1β,
IL-6,
increase
CAT,
SOD,
GSH
activities.
produced
are
suggested
promising
candidates
protection
gastric
ulcers
erosion.
Molecules,
Год журнала:
2024,
Номер
29(8), С. 1718 - 1718
Опубликована: Апрель 10, 2024
Polyphenols,
the
main
antioxidants
of
diet,
have
shown
anti-inflammatory,
antioxidant
and
anticarcinogenic
activities.
Here,
we
compared
effects
four
polyphenolic
compounds
on
ROS
production
levels
matrix
metalloproteinase
(MMP)-2
-9,
which
represent
important
pathogenetic
factors
breast
cancer.
THP-1
differentiated
macrophages
were
activated
by
LPS
simultaneously
treated
with
different
doses
a
green
tea
extract
(GTE),
resveratrol
(RSV),
curcumin
(CRC)
an
olive
fruit
(oliplus).
By
using
2,2-Diphenyl-1-picrylhydrazyl
(DPPH)
radical
scavenging
assay,
found
that
all
tested
showed
activity
in
vitro.
In
addition,
GTE,
RSV
CRC
able
to
counteract
induced
H
