Antibiotics,
Год журнала:
2024,
Номер
13(10), С. 947 - 947
Опубликована: Окт. 9, 2024
Background:
Echinacea
species,
particularly
purpurea,
angustifolia,
and
pallida,
are
renowned
for
their
immunomodulatory,
antibacterial,
antiviral
properties.
Objectives:
This
review
explores
the
mechanisms
by
which
echinacea
herbal
extracts
modulate
immune
responses,
focusing
on
effects
both
innate
adaptive
immunity
in
bacterial
viral
infections.
Results:
Key
bioactive
compounds,
such
as
alkamides,
caffeic
acid
derivatives,
flavonoids,
polysaccharides,
contribute
to
these
effects.
These
compounds
enhance
cell
activity,
including
macrophages
natural
killer
cells,
stimulating
cytokine
production
phagocytosis.
The
antibacterial
activity
of
against
respiratory
pathogens
(Streptococcus
pneumoniae,
Haemophilus
influenzae,
Legionella
pneumophila)
skin
(Staphylococcus
aureus,
Propionibacterium
acnes)
is
reviewed,
well
its
efficacy
viruses
like
herpes
simplex,
influenza,
rhinovirus.
Echinacea’s
potential
a
complementary
treatment
alongside
conventional
antibiotics
antivirals
discussed,
context
antibiotic
resistance
emerging
threats.
Conclusions:
Challenges
associated
with
variability
phytochemical
content
need
standardized
extraction
processes
also
addressed.
provides
comprehensive
overview
echinacea’s
therapeutic
outlines
future
directions
research,
clinical
trials
dosage
optimization.
Polymers,
Год журнала:
2024,
Номер
16(2), С. 259 - 259
Опубликована: Янв. 17, 2024
Health-conscious
consumers
seek
convenient
ways
of
incorporating
different
functional
ingredients
into
their
diets.
Gummy
candies
are
among
the
most
popular
confectionery
products
but
generally
regarded
as
nutritionally
empty.
A
gelatin–sugar
matrix,
providing
a
highly
appreciated
sensory
experience
sweetness
and
chewiness,
could
be
used
to
deliver
various
bioactive
compounds,
especially
those
carrying
an
unpleasant
taste.
This
work
aimed
formulate
gelatin
gummies
based
on
mountain
germander
extract
(MGe)
source
phenylethanoid
glycosides
(PhEG).
Sucrose
glucose
syrup
contents
were
partially
or
completely
substituted
with
combinations
xylitol,
maltitol
prebiotic
poly-
oligosaccharides.
Chemical,
textural
parameters
evaluated
after
production
2
months
storage.
Formulations
containing
fructooligosaccharides
xylooligosaccharides
maintained
characteristic
appearance
during
storage
at
all
three
levels
sugar
(high,
low
none),
whereas
inulin-added
plain
(i.e.,
without
prebiotic)
suffered
from
mold
contamination
appearance/textural
changes.
The
color
noticeably
changed
appeared
darker.
PhEG
shown
stable
candies’
(approximately
90%)
Texture
parameters,
except
hardness,
exhibited
high
positive
correlations
resembled
commercial
product.
Sensory-wise,
moderate
bitterness
intensity
decreasing
tendency,
along
transparency
preservation
shape
facilitated
general
acceptance.
prebiotics
suitable
matrix
for
bitter
MGe,
delivering
up
40
mg
4.5
g
in
one
serving
size.
study
provides
reference
implementing
herbal
extracts
emerging
(XOS)
confectionery.
Phytotherapy Research,
Год журнала:
2024,
Номер
38(4), С. 1838 - 1862
Опубликована: Фев. 14, 2024
Abstract
Mitochondrial
damage
is
associated
with
the
development
of
Parkinson's
disease
(PD),
indicating
that
mitochondrial‐targeted
treatments
could
hold
promise
as
disease‐modifying
approaches
for
PD.
Notably,
natural
compounds
have
demonstrated
ability
to
modulate
mitochondrial‐related
processes.
In
this
review
article,
we
discussed
possible
neuroprotective
mechanisms
against
PD
in
modulating
mitophagy
and
mitochondrial
function.
A
comprehensive
literature
search
on
related
treatment
by
regulating
function
was
conducted
from
PubMed,
Web
Science
Chinese
National
Knowledge
Infrastructure
databases
their
inception
until
April
2023.
We
summarize
recent
advancements
mitophagy's
molecular
mechanisms,
including
upstream
downstream
processes,
its
relationship
PD‐related
genes
or
proteins.
Importantly,
highlight
how
can
therapeutically
regulate
various
processes
through
multiple
targets
pathways
alleviate
oxidative
stress,
neuroinflammation,
Lewy's
body
aggregation
apoptosis,
which
are
key
contributors
pathogenesis.
Unlike
single‐target
strategy
modern
medicine,
provide
neuroprotection
ameliorating
targeting
PINK1/parkin
pathway,
NIX/BNIP3
autophagosome
formation
(i.e.,
LC3
p62).
Given
prevalence
neurodegenerative
diseases,
exploring
exact
mechanism
dysfunction
shed
light
highly
effective
adjuvant
therapies
other
disorders.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 21, 2025
Echinacoside
(ECH),
one
of
the
most
representative
phenylethanoid
glycosides
(PhGs),
has
considerable
neuroprotective
effects
and
is
an
effective
ingredient
in
numerous
commercial
drugs.
Here,
we
elucidate
complete
ECH
biosynthetic
pathway
medicinal
plant
Cistanche
tubulosa.
In
total,
14
related
genes
are
cloned
functionally
characterized.
Two
upstream
pathways
for
tyrosol
biosynthesis
from
L-tyrosine
identified:
includes
separate
decarboxylation,
deamination
reduction
steps;
other
uses
microbial-like
transamination,
decarboxylation
steps.
addition,
a
distinct
downstream
assembly
process
to
revealed
that
sequential
glucosylation,
acylation,
hydroxylation,
rhamnosylation
form
acteoside,
ends
with
final
glucosylation
converting
acteoside
ECH.
Furthermore,
de
novo
synthesis
23
PhG
derivatives
achieved
via
heterologous
expression
different
combinations
functional
tobacco.
Our
findings
provide
insights
into
platform
alternative
production
complex
PhGs.
(ECH)
(PhGs)
responsible
bioactivities
traditional
Chinese
medicine
Herba.
authors
tubulosa
synthesize
PhGs
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
178, С. 117217 - 117217
Опубликована: Июль 29, 2024
Doxorubicin
(DOX),
a
commonly
used
chemotherapy
drug,
is
hindered
due
to
its
tendency
induce
cardiotoxicity
(DIC).
Ferroptosis,
novel
mode
of
programmed
cell
death,
has
received
substantial
attention
for
involvement
in
DIC.
Recently,
natural
product-derived
ferroptosis
regulator
emerged
as
potential
strategy
treating
In
this
review,
comprehensive
search
was
conducted
across
PubMed,
Web
Science,
Google
Scholar,
and
ScienceDirect
databases
gather
relevant
articles
on
the
use
products
DIC
relation
ferroptosis.
The
available
papers
were
carefully
reviewed
summarize
therapeutic
effects
underlying
mechanisms
modulating
treatment.
It
found
that
plays
an
important
role
pathogenesis,
with
dysregulated
expression
ferroptosis-related
proteins
strongly
implicated
condition.
Natural
products,
such
flavonoids,
polyphenols,
terpenoids,
quinones
can
act
GPX4
activators,
Nrf2
agonists,
lipid
peroxidation
inhibitors,
thereby
enhancing
viability,
attenuating
myocardial
fibrosis,
improving
cardiac
function,
suppressing
both
vitro
vivo
models
This
review
demonstrates
strong
correlation
between
DOX-induced
key
proteins,
GPX4,
Keap1,
Nrf2,
AMPK,
HMOX1.
are
likely
exert
against
by
activity
these
proteins.
Biomolecules and Biomedicine,
Год журнала:
2024,
Номер
24(5), С. 1186 - 1198
Опубликована: Март 10, 2024
Hepatocellular
carcinoma
(HCC)
affects
approximately
800,000
individuals
globally
each
year.
Despite
advancements
in
HCC
treatments,
there
is
still
a
pressing
need
to
identify
new
drugs
that
can
combat
resistance.
One
potential
option
echinacoside,
natural
caffeic
acid
glycoside
with
antioxidant,
anti-inflammatory,
antidepressant,
and
antidiabetic
properties.
Therefore,
we
aimed
investigate
the
ability
of
echinacoside
exhibit
antitumor
activity
against
rats
through
ameliorating
hepatic
fibrosis
tumor
invasion.
Rats
were
given
thioacetamide
induce
HCC,
some
30
mg/kg
twice
week
for
16
weeks.
The
liver
impairment
was
assessed
by
measuring
serum
α-fetoprotein
(AFP)
examining
sections
stained
Masson
trichrome
or
anti-transforming
growth
factor
(TGF)-β1
antibodies.
expression
mRNA
protein
levels
TGF-β1,
β-catenin,
SMAD4,
matrix
metalloproteinase-9
(MMP9),
phosphoinositide
3-kinases
(PI3K),
mammalian
target
rapamycin
(mTOR),
connective
tissue
2
(CCN2),
E-Cadherin,
platelets
derived
(PDGF)-B
fascin
also
analyzed.
Echinacoside
improved
survival
rate
decreasing
AFP
number
nodules.
Examination
micro-images
indicated
reduce
fibrosis.
It
significantly
decreased
MMP9,
PI3K,
mTOR,
CCN2,
PDGF-B,
while
enhancing
E-Cadherin.
In
conclusion,
exhibits
protective
effect
increasing
rates
growth.
acts
as
an
inhibitor
pathway
reducing
PDGF-B
mTOR.
Additionally,
it
prevents
invasion
suppressing
MMP9
fascin,
Molecular Nutrition & Food Research,
Год журнала:
2024,
Номер
68(6)
Опубликована: Фев. 17, 2024
Scope
Nonalcoholic
steatohepatitis
(NASH)
is
an
increasingly
common
chronic
liver
disease
in
which
hepatic
fibrosis
the
major
pathological
change.
The
transforming
growth
factor
β
(TGF‐β)/mall
mothers
against
decapentaplegic
(Smad)
signaling
main
effector
of
fibrosis.
Although
antifibrotic
effect
echinacoside
(Ech)
on
has
been
indicated
previously,
cellular
and
molecular
mechanisms
remain
unclear.
This
study
aims
to
investigate
both
vivo
vitro
properties
Ech.
Methods
results
Cell
viability
scratch/wound
assays
show
that
Ech
significantly
inhibits
proliferation,
migration,
activation
human
stellate
LX‐2
cells.
In
mice
with
high‐fat
diet‐induced
fibrosis,
treatment
attenuates
progression
injury,
inflammation,
Furthermore,
transcriptome
analysis
subsequent
functional
validation
demonstrate
achieves
effects
by
activin
receptor
type‐2A
(ACVR2A)‐mediated
TGF‐β1/Smad
pathway;
ultimately,
ACVR2A
demonstrated
be
important
target
for
inhibiting
inducing
expression
Conclusion
exerts
potent
ACVR2A‐mediated
axis
may
serve
as
alternative
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Verbasoside
and
hydroxysalidroside
are
derivatives
of
phenylethanol
glycosides
(PhGs)
that
exhibit
a
range
pharmacological
activities
also
serve
as
valuable
precursors
for
synthesizing
other
more
complex
PhGs.
However,
chemical
synthesis
plant
extraction
large-scale
production
impractical
to
date.
Here,
79
fungi
from
four
types
PhG-containing
plants
their
rhizospheric
soils
were
screened
out,
endophyte
Alternaria
botrytis
RYF1
Rehmannia
glutinosa
was
identified
with
the
ability
generate
verbasoside
decaffeoyl
acteoside.
To
mine
key
enzymes
concerning
biotransformation,
RNA-seq
carried
out
on
RSF6,
which
novel
feruloyl
esterase
DN417
captured.
possesses
hydrolyzing
capabilities
toward
several
DN417's
produce
tested
in
5
L
fermenter,
yielding
50.37
g/L
conversion
rate
94.51%
crude
Finally,
dual-enzyme
synergy
involving
rhamnosidase
designed
hydroxysalidroside.
After
optimization
enzyme
ratios
pH,
approach
successfully
yielded
at
concentration
13.60
81.30%.
The
study
is
first
report
PhGs
laid
solid
foundation
value-added
compounds
