Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
328, С. 118038 - 118038
Опубликована: Март 12, 2024
Bupleurum
chinense
DC.-Scutellaria
baicalensis
Georgi
(BS)
is
a
classic
drug
pair
that
has
good
clinical
effects
on
depression
and
many
tumors.
However,
the
concurrent
targeting
mechanism
of
how
aforementioned
valid
in
two
distinct
diseases,
not
been
clarified
yet.
The
components
BS
were
detected
by
LC-MS,
combined
with
network
pharmacology
to
explore
active
ingredients
common
its
multi-pathway
regulation
treating
CRC,
validate
dual
using
CUMS
mice
model
orthotopic
transplantation
tumor
CRC.
Twenty-nine
screened,
84
gene
targets
obteined,
top
5
key
including
STAT3,
PIK3R1,
PIK3CA,
AKT1,
IL-6
identified
PPI
network.
GO
KEGG
analyses
revealed
PI3K/AKT
JAK/STAT
signaling
pathways
might
play
crucial
role
regulating
significantly
modulated
CUMS-induced
depressive-like
behavior,
attenuated
neuronal
damage,
reduced
serum
EPI
NE
levels
mice.
improved
pathological
histological
changes
solid
tumors
liver
tissues
inhibited
metastases
CT26-bearing
decreased
proteins'
expression
IL-6,
p-JAK2,
p-STAT3,
p-PI3K,
p-AKT1
hippocampal
tumors,
regulated
IL-2,
IL-10
models
can
exert
antidepressant
anti-CRC
inhibiting
IL-6/JAK2/STAT3
pathway
proteins
release
inflammatory
cytokines.
Pharmacological Research,
Год журнала:
2024,
Номер
203, С. 107148 - 107148
Опубликована: Март 22, 2024
The
gut
microbiota,
known
as
the
"forgotten
organ"
and
"human
second
genome,"
comprises
a
complex
microecosystem.
It
significantly
influences
development
of
various
tumors,
including
colorectal,
liver,
stomach,
breast,
lung
cancers,
through
both
direct
indirect
mechanisms.
These
mechanisms
include
"gut-liver"
axis,
"lung-intestine"
interactions
with
immune
system.
intestinal
flora
exhibits
dual
roles
in
cancer,
promoting
suppressing
its
progression.
Traditional
Chinese
medicine
(TCM)
can
alter
cancer
progression
by
regulating
flora.
modifies
flora's
composition
structure,
along
levels
endogenous
metabolites,
thus
affecting
barrier,
system,
overall
body
metabolism.
actions
contribute
to
TCM's
significant
antitumor
effects.
Moreover,
microbiota
metabolizes
TCM
components,
enhancing
their
properties.
Therefore,
exploring
interaction
between
offers
novel
perspective
understanding
This
paper
succinctly
reviews
association
gastric,
cancers.
further
examines
current
research
on
flora,
focus
efficacy.
identifies
limitations
existing
studies
suggests
recommendations,
providing
insights
into
drug
effectiveness.
Additionally,
this
aims
guide
future
studies.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 25, 2024
Depression,
projected
to
be
the
predominant
contributor
global
disease
burden,
is
a
complex
condition
with
diverse
symptoms
including
mood
disturbances
and
cognitive
impairments.
Traditional
treatments
such
as
medication
psychotherapy
often
fall
short,
prompting
pursuit
of
alternative
interventions.
Recent
research
has
highlighted
significant
role
gut
microbiota
in
mental
health,
influencing
emotional
neural
regulation.
Fecal
transplantation
(FMT),
infusion
fecal
matter
from
healthy
donor
into
patient,
emerges
promising
strategy
ameliorate
depressive
by
restoring
microbial
balance.
The
microbial-gut-brain
(MGB)
axis
represents
critical
pathway
through
which
potentially
rectify
dysbiosis
modulate
neuropsychiatric
outcomes.
Preclinical
studies
reveal
that
FMT
can
enhance
neurochemicals
reduce
inflammatory
markers,
thereby
alleviating
behaviors.
Moreover,
shown
promise
clinical
settings,
improving
gastrointestinal
overall
quality
life
patients
depression.
review
highlights
gut-brain
depression
need
for
further
validate
long-term
safety
efficacy
FMT,
identify
specific
therapeutic
strains,
develop
targeted
modulation
strategies.
Advancing
our
understanding
could
revolutionize
treatment,
shifting
paradigm
toward
microbiome-targeting
therapies.
Journal of Cellular and Molecular Medicine,
Год журнала:
2023,
Номер
27(23), С. 3928 - 3938
Опубликована: Окт. 6, 2023
Abstract
Major
depressive
disorder
(MDD)
is
a
severe
mental
associated
with
high
rates
of
morbidity
and
mortality.
Current
first‐line
pharmacotherapies
for
MDD
are
based
on
enhancement
monoaminergic
neurotransmission,
but
these
antidepressants
still
insufficient
produce
significant
side‐effects.
Consequently,
the
development
novel
therapeutic
targets
desired.
Engeletin,
natural
Smilax
glabra
rhizomilax
derivative,
compound
proven
efficacy
in
treating
ischemic
stroke,
yet
its
effects
mechanisms
depression
remain
unexplored.
The
engeletin
were
assessed
forced
swimming
test
(FST)
tail
suspension
(TST)
mice.
Engeletin
was
also
investigated
chronic
restraint
stress
(CRS)
mouse
model
fluoxetine
(FLX)
as
positive
control.
Changes
prefrontal
cortex
(PFC)
spine
density,
synaptic
plasticity‐linked
protein
expressions
brain‐derived
neurotrophic
factor
(BDNF)‐tyrosine
kinase
B
(TrkB)‐
mammalian
target
rapamycin
complex
1
(mTORC1)
signalling
pathway
after
treatment
then
investigated.
TrkB
mTORC1
selective
inhibitors,
ANA‐12
rapamycin,
respectively,
utilized
to
assess
engeletin's
antidepressive
mechanisms.
Our
data
shows
that
exhibited
antidepressant‐like
activity
FST
TST
mice
without
affecting
locomotor
activity.
Furthermore,
it
efficiency
against
CRS
model.
Moreover,
enhanced
BDNF‐TrkB‐mTORC1
PFC
during
altered
reduction
dendritic
density
levels
induced
by
CRS.
In
conclusion,
has
antidepressant
via
activation
upregulation
plasticity.
Food & Function,
Год журнала:
2023,
Номер
14(7), С. 3304 - 3318
Опубликована: Янв. 1, 2023
The
prevention,
mitigation
and
treatment
of
depression
has
become
a
global
issue
that
needs
to
be
solved
urgently.
Sayram
Ketteki,
traditional
natural
fermented
yoghurt
from
the
region
with
world's
fourth
highest
life
expectancy,
been
known
as
"longevity
secret",
whose
longevity
anti-depression
factors
are
speculated
come
its
rich
microorganisms.
Therefore,
for
first
time,
we
systematically
studied
in
depth
microbes
screened
new
edible
probiotic
strain,
Lactiplantibacillus
plantarum
R6-3,
explored
effect
chronic
unpredictable
mild
stress
(CUMS)-induced
mice.
It
is
encouraging
L.
R6-3
was
significantly
superior
classic
anti-depressant
drug,
fluoxetine,
performance
promoting
sucrose
preference
test
(SPT)
behavior
by
18%
(p
<
0.001),
lowering
serum
CORT
content
5.6%
0.05),
accelerating
brain-derived
neurotrophic
factor
(BDNF)
level
5.9%
0.01),
increasing
IL-10
concentration
2.3%
up-regulating
expression
BDNF
phosphorylated-ERK
74%
0.01)
45%
respectively,
facilitating
secretion
fecal
short-chain
fatty
acids
(SCFAs),
including
n-butyric,
n-valeric,
isovaleric
acid
47%
42%
0.05)
38%
respectively.
Through
microbiota-gut-brain
axis,
promoted
intestinal
SCFAs
through
regulation
composition
function
gut
microbiota,
activated
production
monoamine
neurotransmitter,
renewed
brain
factor,
suppressed
hyperactivity
hypothalamic-pituitary-adrenal
(HPA)
axis
adjusting
hippocampal
BDNF/TrkB/ERK/CREB
signaling
pathway,
thereby
improving
immune
oxidative
status,
protecting
tissue
damage,
maintaining
healthy
weight
preventing
CUMS-induced
depressive
great
prospects
development
functional
foods,
prevention
innovative
microecological
preparations.
Pharmacological Research,
Год журнала:
2024,
Номер
205, С. 107255 - 107255
Опубликована: Июнь 12, 2024
Research
has
shown
that
a
significant
portion
of
cancer
patients
experience
depressive
symptoms,
often
accompanied
by
neuroendocrine
hormone
imbalances.
Depression
is
frequently
associated
with
decreased
levels
serotonin
the
alternate
name
5-hydroxytryptamine
(5-HT),
leading
to
common
use
selective
reuptake
inhibitors
(SSRIs)
as
antidepressants.
However,
role
in
tumor
regulation
remains
unclear,
its
expression
displaying
varied
effects
across
different
types
tumors.
Tumor
initiation
and
progression
are
closely
intertwined
immune
function
human
body.
Neuroimmunity,
an
interdisciplinary
subject,
played
unique
study
relationship
between
psychosocial
factors
tumors
their
mechanisms
recent
years.
This
article
offers
comprehensive
review
serotonin's
regulatory
roles
onset
progression,
well
impacts
on
cells
microenvironment.
The
aim
stimulate
further
research
discover
novel
targets
for
treatment.
Frontiers in Microbiology,
Год журнала:
2022,
Номер
13
Опубликована: Авг. 4, 2022
Colorectal
cancer
(CRC)
ranks
third
in
terms
of
global
incidence
and
second
death
toll
among
malignant
tumors.
Gut
microbiota
are
involved
the
formation,
development,
responses
to
different
treatments
CRC.
Under
normal
physiological
conditions,
intestinal
microorganisms
protect
mucosa,
resist
pathogen
invasion,
regulate
proliferation
mucosal
cells
via
a
barrier
effect
inhibition
DNA
damage.
The
composition
gut
influences
diet,
drugs,
gender
on
flora
important
factors
early
detection
CRC
prediction
results
treatment.
Regulation
is
one
most
promising
new
strategies
for
treatment,
it
essential
clarify
its
possible
mechanisms
facilitate
prevention
treatment
This
review
discusses
role
pathogenesis
CRC,
potential
as
biomarkers
therapeutic
approaches
based
regulation
microbiota.
It
might
provide
ideas
use
near
future
thus
reduce
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 6, 2023
Digestive
tract-related
cancers
account
for
four
of
the
top
ten
high-risk
worldwide.
In
recent
years,
cancer
immunotherapy,
which
exploits
innate
immune
system
to
attack
tumors,
has
led
a
paradigm
shifts
in
treatment.
Gut
microbiota
modification
been
widely
used
regulate
immunotherapy.
Dietary
compounds
and
traditional
Chinese
medicine
(TCM)
can
alter
gut
its
influence
on
toxic
metabolite
production,
such
as
effect
iprindole
lipopolysaccharide
(LPS),
involvement
various
metabolic
pathways
that
are
closely
associated
with
reactions.
Therefore,
it
is
an
effective
strategy
explore
new
immunotherapies
gastrointestinal
clarify
immunoregulatory
effects
different
dietary
compounds/TCMs
intestinal
microbiota.
this
review,
we
have
summarized
progress
regarding
their
metabolites,
well
relationship
between
digestive
immunotherapy
We
hope
review
will
act
reference,
providing
theoretical
basis
clinical
via
modulation.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Июль 4, 2023
Objective:
Traditional
Chinese
medicine
(TCM)
has
been
used
as
a
complementary
treatment
for
cancer
patients,
but
there
no
quantitative
comprehensive
analysis
of
TCM's
efficacy.
The
purpose
this
paper
is
to
explore
the
current
status
and
hotspots
TCM
in
research
from
2002
2022
provide
reference
future
research.
Methods:
We
retrieved
articles
published
between
Web
Science
database
analyzed
them
using
R
software,
VOSviewer,
CiteSpace
software.
Results:
A
total
7,129
were
included
study.
publication
rate
increased
steadily
2022,
with
rapid
increase
2010
2021.
China
was
country
most
articles,
followed
by
United
States,
Republic
Korea,
Germany,
Japan.
also
international
collaborations,
Medical
University
Shanghai
Medicine
representative
cooperation
centers.
Journal
Ethnopharmacology
cited
journal.
Apoptosis,
expression,
vitro,
activation,
other
related
keywords
commonly
these
articles.
Breast
cancer,
colorectal
gastric
liver
lung
studied
types
Pathway-related
apoptosis,
anti-inflammation,
oxidative
stress
trends
anti-cancer
mechanism.
Metabolomics
combined
network
pharmacology
main
method.
Conclusion:
an
drug
received
increasing
attention
researchers
worldwide,
it
expected
be
hotspot
developing
new
drugs
future.
Our
study
provides
research,
which
could
serve
valuable
studies.