The interactions between traditional Chinese medicine and gut microbiota in cancers: Current status and future perspectives

Pharmacological Research, Год журнала: 2024, Номер 203, С. 107148 - 107148

Опубликована: Март 22, 2024

The gut microbiota, known as the "forgotten organ" and "human second genome," comprises a complex microecosystem. It significantly influences development of various tumors, including colorectal, liver, stomach, breast, lung cancers, through both direct indirect mechanisms. These mechanisms include "gut-liver" axis, "lung-intestine" interactions with immune system. intestinal flora exhibits dual roles in cancer, promoting suppressing its progression. Traditional Chinese medicine (TCM) can alter cancer progression by regulating flora. modifies flora's composition structure, along levels endogenous metabolites, thus affecting barrier, system, overall body metabolism. actions contribute to TCM's significant antitumor effects. Moreover, microbiota metabolizes TCM components, enhancing their properties. Therefore, exploring interaction between offers novel perspective understanding This paper succinctly reviews association gastric, cancers. further examines current research on flora, focus efficacy. identifies limitations existing studies suggests recommendations, providing insights into drug effectiveness. Additionally, this aims guide future studies.

Язык: Английский

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Current landscape of fecal microbiota transplantation in treating depression

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июнь 25, 2024

Depression, projected to be the predominant contributor global disease burden, is a complex condition with diverse symptoms including mood disturbances and cognitive impairments. Traditional treatments such as medication psychotherapy often fall short, prompting pursuit of alternative interventions. Recent research has highlighted significant role gut microbiota in mental health, influencing emotional neural regulation. Fecal transplantation (FMT), infusion fecal matter from healthy donor into patient, emerges promising strategy ameliorate depressive by restoring microbial balance. The microbial-gut-brain (MGB) axis represents critical pathway through which potentially rectify dysbiosis modulate neuropsychiatric outcomes. Preclinical studies reveal that FMT can enhance neurochemicals reduce inflammatory markers, thereby alleviating behaviors. Moreover, shown promise clinical settings, improving gastrointestinal overall quality life patients depression. review highlights gut-brain depression need for further validate long-term safety efficacy FMT, identify specific therapeutic strains, develop targeted modulation strategies. Advancing our understanding could revolutionize treatment, shifting paradigm toward microbiome-targeting therapies.

Язык: Английский

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PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids

Phytomedicine, Год журнала: 2024, Номер 132, С. 155795 - 155795

Опубликована: Июнь 3, 2024

Язык: Английский

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Engeletin alleviates depression‐like phenotype by increasing synaptic plasticity via the BDNF‐TrkB‐mTORC1 signalling pathway

Journal of Cellular and Molecular Medicine, Год журнала: 2023, Номер 27(23), С. 3928 - 3938

Опубликована: Окт. 6, 2023

Abstract Major depressive disorder (MDD) is a severe mental associated with high rates of morbidity and mortality. Current first‐line pharmacotherapies for MDD are based on enhancement monoaminergic neurotransmission, but these antidepressants still insufficient produce significant side‐effects. Consequently, the development novel therapeutic targets desired. Engeletin, natural Smilax glabra rhizomilax derivative, compound proven efficacy in treating ischemic stroke, yet its effects mechanisms depression remain unexplored. The engeletin were assessed forced swimming test (FST) tail suspension (TST) mice. Engeletin was also investigated chronic restraint stress (CRS) mouse model fluoxetine (FLX) as positive control. Changes prefrontal cortex (PFC) spine density, synaptic plasticity‐linked protein expressions brain‐derived neurotrophic factor (BDNF)‐tyrosine kinase B (TrkB)‐ mammalian target rapamycin complex 1 (mTORC1) signalling pathway after treatment then investigated. TrkB mTORC1 selective inhibitors, ANA‐12 rapamycin, respectively, utilized to assess engeletin's antidepressive mechanisms. Our data shows that exhibited antidepressant‐like activity FST TST mice without affecting locomotor activity. Furthermore, it efficiency against CRS model. Moreover, enhanced BDNF‐TrkB‐mTORC1 PFC during altered reduction dendritic density levels induced by CRS. In conclusion, has antidepressant via activation upregulation plasticity.

Язык: Английский

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Study onLactiplantibacillus plantarumR6-3 from Sayram Ketteki to prevent chronic unpredictable mild stress-induced depression in mice through the microbiota–gut–brain axis

Food & Function, Год журнала: 2023, Номер 14(7), С. 3304 - 3318

Опубликована: Янв. 1, 2023

The prevention, mitigation and treatment of depression has become a global issue that needs to be solved urgently. Sayram Ketteki, traditional natural fermented yoghurt from the region with world's fourth highest life expectancy, been known as "longevity secret", whose longevity anti-depression factors are speculated come its rich microorganisms. Therefore, for first time, we systematically studied in depth microbes screened new edible probiotic strain, Lactiplantibacillus plantarum R6-3, explored effect chronic unpredictable mild stress (CUMS)-induced mice. It is encouraging L. R6-3 was significantly superior classic anti-depressant drug, fluoxetine, performance promoting sucrose preference test (SPT) behavior by 18% (p < 0.001), lowering serum CORT content 5.6% 0.05), accelerating brain-derived neurotrophic factor (BDNF) level 5.9% 0.01), increasing IL-10 concentration 2.3% up-regulating expression BDNF phosphorylated-ERK 74% 0.01) 45% respectively, facilitating secretion fecal short-chain fatty acids (SCFAs), including n-butyric, n-valeric, isovaleric acid 47% 42% 0.05) 38% respectively. Through microbiota-gut-brain axis, promoted intestinal SCFAs through regulation composition function gut microbiota, activated production monoamine neurotransmitter, renewed brain factor, suppressed hyperactivity hypothalamic-pituitary-adrenal (HPA) axis adjusting hippocampal BDNF/TrkB/ERK/CREB signaling pathway, thereby improving immune oxidative status, protecting tissue damage, maintaining healthy weight preventing CUMS-induced depressive great prospects development functional foods, prevention innovative microecological preparations.

Язык: Английский

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Uncovering the effect and mechanism of Jiawei Xiaoyao Wan in treating breast cancer complicated with depression based on network pharmacology and experimental analysis

Phytomedicine, Год журнала: 2024, Номер 128, С. 155427 - 155427

Опубликована: Фев. 7, 2024

Язык: Английский

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The dual roles of serotonin in antitumor immunity

Pharmacological Research, Год журнала: 2024, Номер 205, С. 107255 - 107255

Опубликована: Июнь 12, 2024

Research has shown that a significant portion of cancer patients experience depressive symptoms, often accompanied by neuroendocrine hormone imbalances. Depression is frequently associated with decreased levels serotonin the alternate name 5-hydroxytryptamine (5-HT), leading to common use selective reuptake inhibitors (SSRIs) as antidepressants. However, role in tumor regulation remains unclear, its expression displaying varied effects across different types tumors. Tumor initiation and progression are closely intertwined immune function human body. Neuroimmunity, an interdisciplinary subject, played unique study relationship between psychosocial factors tumors their mechanisms recent years. This article offers comprehensive review serotonin's regulatory roles onset progression, well impacts on cells microenvironment. The aim stimulate further research discover novel targets for treatment.

Язык: Английский

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Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota

Frontiers in Microbiology, Год журнала: 2022, Номер 13

Опубликована: Авг. 4, 2022

Colorectal cancer (CRC) ranks third in terms of global incidence and second death toll among malignant tumors. Gut microbiota are involved the formation, development, responses to different treatments CRC. Under normal physiological conditions, intestinal microorganisms protect mucosa, resist pathogen invasion, regulate proliferation mucosal cells via a barrier effect inhibition DNA damage. The composition gut influences diet, drugs, gender on flora important factors early detection CRC prediction results treatment. Regulation is one most promising new strategies for treatment, it essential clarify its possible mechanisms facilitate prevention treatment This review discusses role pathogenesis CRC, potential as biomarkers therapeutic approaches based regulation microbiota. It might provide ideas use near future thus reduce

Язык: Английский

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The effects of traditional Chinese medicine and dietary compounds on digestive cancer immunotherapy and gut microbiota modulation: A review

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Фев. 6, 2023

Digestive tract-related cancers account for four of the top ten high-risk worldwide. In recent years, cancer immunotherapy, which exploits innate immune system to attack tumors, has led a paradigm shifts in treatment. Gut microbiota modification been widely used regulate immunotherapy. Dietary compounds and traditional Chinese medicine (TCM) can alter gut its influence on toxic metabolite production, such as effect iprindole lipopolysaccharide (LPS), involvement various metabolic pathways that are closely associated with reactions. Therefore, it is an effective strategy explore new immunotherapies gastrointestinal clarify immunoregulatory effects different dietary compounds/TCMs intestinal microbiota. this review, we have summarized progress regarding their metabolites, well relationship between digestive immunotherapy We hope review will act reference, providing theoretical basis clinical via modulation.

Язык: Английский

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Bibliometric and visual analysis in the field of traditional Chinese medicine in cancer from 2002 to 2022

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Июль 4, 2023

Objective: Traditional Chinese medicine (TCM) has been used as a complementary treatment for cancer patients, but there no quantitative comprehensive analysis of TCM's efficacy. The purpose this paper is to explore the current status and hotspots TCM in research from 2002 2022 provide reference future research. Methods: We retrieved articles published between Web Science database analyzed them using R software, VOSviewer, CiteSpace software. Results: A total 7,129 were included study. publication rate increased steadily 2022, with rapid increase 2010 2021. China was country most articles, followed by United States, Republic Korea, Germany, Japan. also international collaborations, Medical University Shanghai Medicine representative cooperation centers. Journal Ethnopharmacology cited journal. Apoptosis, expression, vitro, activation, other related keywords commonly these articles. Breast cancer, colorectal gastric liver lung studied types Pathway-related apoptosis, anti-inflammation, oxidative stress trends anti-cancer mechanism. Metabolomics combined network pharmacology main method. Conclusion: an drug received increasing attention researchers worldwide, it expected be hotspot developing new drugs future. Our study provides research, which could serve valuable studies.

Язык: Английский

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