The interactions between traditional Chinese medicine and gut microbiota in cancers: Current status and future perspectives

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107148 - 107148

Published: March 22, 2024

The gut microbiota, known as the "forgotten organ" and "human second genome," comprises a complex microecosystem. It significantly influences development of various tumors, including colorectal, liver, stomach, breast, lung cancers, through both direct indirect mechanisms. These mechanisms include "gut-liver" axis, "lung-intestine" interactions with immune system. intestinal flora exhibits dual roles in cancer, promoting suppressing its progression. Traditional Chinese medicine (TCM) can alter cancer progression by regulating flora. modifies flora's composition structure, along levels endogenous metabolites, thus affecting barrier, system, overall body metabolism. actions contribute to TCM's significant antitumor effects. Moreover, microbiota metabolizes TCM components, enhancing their properties. Therefore, exploring interaction between offers novel perspective understanding This paper succinctly reviews association gastric, cancers. further examines current research on flora, focus efficacy. identifies limitations existing studies suggests recommendations, providing insights into drug effectiveness. Additionally, this aims guide future studies.

Language: Английский

---

Current landscape of fecal microbiota transplantation in treating depression

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 25, 2024

Depression, projected to be the predominant contributor global disease burden, is a complex condition with diverse symptoms including mood disturbances and cognitive impairments. Traditional treatments such as medication psychotherapy often fall short, prompting pursuit of alternative interventions. Recent research has highlighted significant role gut microbiota in mental health, influencing emotional neural regulation. Fecal transplantation (FMT), infusion fecal matter from healthy donor into patient, emerges promising strategy ameliorate depressive by restoring microbial balance. The microbial-gut-brain (MGB) axis represents critical pathway through which potentially rectify dysbiosis modulate neuropsychiatric outcomes. Preclinical studies reveal that FMT can enhance neurochemicals reduce inflammatory markers, thereby alleviating behaviors. Moreover, shown promise clinical settings, improving gastrointestinal overall quality life patients depression. review highlights gut-brain depression need for further validate long-term safety efficacy FMT, identify specific therapeutic strains, develop targeted modulation strategies. Advancing our understanding could revolutionize treatment, shifting paradigm toward microbiome-targeting therapies.

Language: Английский

---

PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids

Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155795 - 155795

Published: June 3, 2024

Language: Английский

---

Study onLactiplantibacillus plantarumR6-3 from Sayram Ketteki to prevent chronic unpredictable mild stress-induced depression in mice through the microbiota–gut–brain axis

Food & Function, Journal Year: 2023, Volume and Issue: 14(7), P. 3304 - 3318

Published: Jan. 1, 2023

The prevention, mitigation and treatment of depression has become a global issue that needs to be solved urgently. Sayram Ketteki, traditional natural fermented yoghurt from the region with world's fourth highest life expectancy, been known as "longevity secret", whose longevity anti-depression factors are speculated come its rich microorganisms. Therefore, for first time, we systematically studied in depth microbes screened new edible probiotic strain, Lactiplantibacillus plantarum R6-3, explored effect chronic unpredictable mild stress (CUMS)-induced mice. It is encouraging L. R6-3 was significantly superior classic anti-depressant drug, fluoxetine, performance promoting sucrose preference test (SPT) behavior by 18% (p < 0.001), lowering serum CORT content 5.6% 0.05), accelerating brain-derived neurotrophic factor (BDNF) level 5.9% 0.01), increasing IL-10 concentration 2.3% up-regulating expression BDNF phosphorylated-ERK 74% 0.01) 45% respectively, facilitating secretion fecal short-chain fatty acids (SCFAs), including n-butyric, n-valeric, isovaleric acid 47% 42% 0.05) 38% respectively. Through microbiota-gut-brain axis, promoted intestinal SCFAs through regulation composition function gut microbiota, activated production monoamine neurotransmitter, renewed brain factor, suppressed hyperactivity hypothalamic-pituitary-adrenal (HPA) axis adjusting hippocampal BDNF/TrkB/ERK/CREB signaling pathway, thereby improving immune oxidative status, protecting tissue damage, maintaining healthy weight preventing CUMS-induced depressive great prospects development functional foods, prevention innovative microecological preparations.

Language: Английский

---

Engeletin alleviates depression‐like phenotype by increasing synaptic plasticity via the BDNF‐TrkB‐mTORC1 signalling pathway

Journal of Cellular and Molecular Medicine, Journal Year: 2023, Volume and Issue: 27(23), P. 3928 - 3938

Published: Oct. 6, 2023

Abstract Major depressive disorder (MDD) is a severe mental associated with high rates of morbidity and mortality. Current first‐line pharmacotherapies for MDD are based on enhancement monoaminergic neurotransmission, but these antidepressants still insufficient produce significant side‐effects. Consequently, the development novel therapeutic targets desired. Engeletin, natural Smilax glabra rhizomilax derivative, compound proven efficacy in treating ischemic stroke, yet its effects mechanisms depression remain unexplored. The engeletin were assessed forced swimming test (FST) tail suspension (TST) mice. Engeletin was also investigated chronic restraint stress (CRS) mouse model fluoxetine (FLX) as positive control. Changes prefrontal cortex (PFC) spine density, synaptic plasticity‐linked protein expressions brain‐derived neurotrophic factor (BDNF)‐tyrosine kinase B (TrkB)‐ mammalian target rapamycin complex 1 (mTORC1) signalling pathway after treatment then investigated. TrkB mTORC1 selective inhibitors, ANA‐12 rapamycin, respectively, utilized to assess engeletin's antidepressive mechanisms. Our data shows that exhibited antidepressant‐like activity FST TST mice without affecting locomotor activity. Furthermore, it efficiency against CRS model. Moreover, enhanced BDNF‐TrkB‐mTORC1 PFC during altered reduction dendritic density levels induced by CRS. In conclusion, has antidepressant via activation upregulation plasticity.

Language: Английский

---

The dual roles of serotonin in antitumor immunity

Pharmacological Research, Journal Year: 2024, Volume and Issue: 205, P. 107255 - 107255

Published: June 12, 2024

Research has shown that a significant portion of cancer patients experience depressive symptoms, often accompanied by neuroendocrine hormone imbalances. Depression is frequently associated with decreased levels serotonin the alternate name 5-hydroxytryptamine (5-HT), leading to common use selective reuptake inhibitors (SSRIs) as antidepressants. However, role in tumor regulation remains unclear, its expression displaying varied effects across different types tumors. Tumor initiation and progression are closely intertwined immune function human body. Neuroimmunity, an interdisciplinary subject, played unique study relationship between psychosocial factors tumors their mechanisms recent years. This article offers comprehensive review serotonin's regulatory roles onset progression, well impacts on cells microenvironment. The aim stimulate further research discover novel targets for treatment.

Language: Английский

---

Uncovering the effect and mechanism of Jiawei Xiaoyao Wan in treating breast cancer complicated with depression based on network pharmacology and experimental analysis

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155427 - 155427

Published: Feb. 7, 2024

Language: Английский

---

Engeletin alleviates depressive‐like behaviours by modulating microglial polarization via the LCN2/CXCL10 signalling pathway

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(8)

Published: April 1, 2024

Microglial polarization and associated inflammatory activity are the key mediators of depression pathogenesis. The natural Smilax glabra rhizomilax derivative engeletin has been reported to exhibit robust anti-inflammatory activity, but no studies date have examined mechanisms through which it can treat depressive symptoms. We showed that treatment for 21 days with significantly alleviated depressive-like behaviours in chronic stress social defeat (CSDS) model mice. T1-weighted imaging (T1WI), T2-weighted (T2WI) revealed significant differences between groups, bilateral prefrontal cortex CSDS mice exhibited increases apparent diffusion coefficient T2 values relative normal control mice, a corresponding reduction fractional anisotropy, while reversed all these changes. resulted higher levels IL-1β, IL-6, TNF-a production, enhanced microglial activation, greater M1 concomitant decrease M2 mPFC, whereas effectively abrogated CSDS-related pathological Engeletin was further found suppress LCN2/C-X-C motif chemokine ligand 10 (CXCL10) signalling axis such adeno-associated virus-induced LCN2 overexpression ablated antidepressant effects its beneficial on M1/M2 microglia. In conclusion, alleviate CSDS-induced by regulating LCN2/CXCL10 pathway thereby altering These data suggest correlated microglia, highlighting potential avenue future design strategies specifically target

Language: Английский

---

Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 4, 2022

Colorectal cancer (CRC) ranks third in terms of global incidence and second death toll among malignant tumors. Gut microbiota are involved the formation, development, responses to different treatments CRC. Under normal physiological conditions, intestinal microorganisms protect mucosa, resist pathogen invasion, regulate proliferation mucosal cells via a barrier effect inhibition DNA damage. The composition gut influences diet, drugs, gender on flora important factors early detection CRC prediction results treatment. Regulation is one most promising new strategies for treatment, it essential clarify its possible mechanisms facilitate prevention treatment This review discusses role pathogenesis CRC, potential as biomarkers therapeutic approaches based regulation microbiota. It might provide ideas use near future thus reduce

Language: Английский

---

The effects of traditional Chinese medicine and dietary compounds on digestive cancer immunotherapy and gut microbiota modulation: A review

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 6, 2023

Digestive tract-related cancers account for four of the top ten high-risk worldwide. In recent years, cancer immunotherapy, which exploits innate immune system to attack tumors, has led a paradigm shifts in treatment. Gut microbiota modification been widely used regulate immunotherapy. Dietary compounds and traditional Chinese medicine (TCM) can alter gut its influence on toxic metabolite production, such as effect iprindole lipopolysaccharide (LPS), involvement various metabolic pathways that are closely associated with reactions. Therefore, it is an effective strategy explore new immunotherapies gastrointestinal clarify immunoregulatory effects different dietary compounds/TCMs intestinal microbiota. this review, we have summarized progress regarding their metabolites, well relationship between digestive immunotherapy We hope review will act reference, providing theoretical basis clinical via modulation.

Language: Английский

---