CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(8)
Опубликована: Авг. 1, 2024
Abstract
Background
Alzheimer's
disease
(AD)
pathogenesis
is
complex.
The
pathophysiology
not
fully
understood,
and
safe
effective
treatments
are
needed.
Glycogen
synthase
kinase
3β
(GSK‐3β)
mediates
AD
progression
through
several
signaling
pathways.
Recently,
studies
have
found
that
various
natural
compounds
from
herbs
nutraceuticals
can
significantly
improve
symptoms.
Aims
This
review
aims
to
provide
a
comprehensive
summary
of
the
potential
neuroprotective
impacts
as
inhibitors
GSK‐3β
in
treatment
AD.
Materials
Methods
We
conducted
systematic
literature
search
on
PubMed,
ScienceDirect,
Web
Science,
Google
Scholar,
focusing
vitro
vivo
investigated
Results
mechanism
may
be
related
activation
inhibition
regulate
amyloid
beta
production,
tau
protein
hyperphosphorylation,
cell
apoptosis,
cellular
inflammation.
By
reviewing
recent
phytochemicals
intervention,
flavonoids
including
oxyphylla
A,
quercetin,
morin,
icariin,
linarin,
genipin,
isoorientin
were
reported
potent
for
treatment.
Polyphenols
such
schisandrin
B,
magnolol,
dieckol
inhibitory
effects
models,
models.
Sulforaphene,
ginsenoside
Rd,
gypenoside
XVII,
falcarindiol,
epibrassinolides,
1,8‐Cineole,
andrographolide
promising
inhibitors.
Conclusions
Natural
candidates
They
qualify
derivatives
development
enhanced
pharmacological
characteristics.
Plant Biotechnology Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Summary
Sugar
building
blocks
are
crucial
for
the
chemical
diversity
and
biological
activity
of
secondary
metabolites.
UDP‐dependent
glycosyltransferases
(UGTs)
play
a
pivotal
role
in
biosynthesis
glycosides
plants
by
catalysing
attachment
sugar
moieties
to
various
bioactive
natural
products.
However,
oligosaccharide‐chain
is
often
limited
narrow
substrate
specificity
UGTs.
In
this
study,
we
identify
regio‐specific
β
‐(1,6)
glycosyltransferase,
UGT94BY1,
from
Platycodon
grandiflorum
.
UGT94BY1
exhibits
broad
promiscuity
can
transfer
up
three
C6‐OH
position
glucosyl
group
triterpenoids
phenolic
glycosides,
thereby
forming
oligoglucoside
chains.
To
elucidate
mechanism
underlying
its
selectivity,
determined
crystal
structure
complex
with
UDP
at
resolution
2.0
Å.
Molecular
simulations
revealed
that
critical
structural
motif,
comprising
residues
N84‐M91,
S141‐L155
R179‐E186,
plays
key
recognizing
acceptors
facilitating
chain
elongation.
Our
study
unveils
powerful
glycosyltransferase
highlights
regions
involved
recognition
extension,
providing
valuable
insights
designing
UGTs
customized
specificities
biotechnological
applications.
Molecular Medicine,
Год журнала:
2024,
Номер
30(1)
Опубликована: Апрель 26, 2024
Ginsenoside
Rh2
(G-Rh2),
a
steroidal
compound
extracted
from
roots
of
ginseng,
has
been
extensively
studied
in
tumor
therapy.
However,
its
specific
regulatory
mechanism
non-small
cell
lung
cancer
(NSCLC)
is
not
well
understood.
Pyruvate
dehydrogenase
kinase
4
(PDK4),
central
regulator
cellular
energy
metabolism,
highly
expressed
various
malignant
tumors.
We
investigated
the
impact
G-Rh2
on
progression
NSCLC
and
how
it
regulated
PDK4
to
influence
aerobic
glycolysis
mitochondrial
function.
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(8)
Опубликована: Авг. 1, 2024
Abstract
Background
Alzheimer's
disease
(AD)
pathogenesis
is
complex.
The
pathophysiology
not
fully
understood,
and
safe
effective
treatments
are
needed.
Glycogen
synthase
kinase
3β
(GSK‐3β)
mediates
AD
progression
through
several
signaling
pathways.
Recently,
studies
have
found
that
various
natural
compounds
from
herbs
nutraceuticals
can
significantly
improve
symptoms.
Aims
This
review
aims
to
provide
a
comprehensive
summary
of
the
potential
neuroprotective
impacts
as
inhibitors
GSK‐3β
in
treatment
AD.
Materials
Methods
We
conducted
systematic
literature
search
on
PubMed,
ScienceDirect,
Web
Science,
Google
Scholar,
focusing
vitro
vivo
investigated
Results
mechanism
may
be
related
activation
inhibition
regulate
amyloid
beta
production,
tau
protein
hyperphosphorylation,
cell
apoptosis,
cellular
inflammation.
By
reviewing
recent
phytochemicals
intervention,
flavonoids
including
oxyphylla
A,
quercetin,
morin,
icariin,
linarin,
genipin,
isoorientin
were
reported
potent
for
treatment.
Polyphenols
such
schisandrin
B,
magnolol,
dieckol
inhibitory
effects
models,
models.
Sulforaphene,
ginsenoside
Rd,
gypenoside
XVII,
falcarindiol,
epibrassinolides,
1,8‐Cineole,
andrographolide
promising
inhibitors.
Conclusions
Natural
candidates
They
qualify
derivatives
development
enhanced
pharmacological
characteristics.
