Therapeutic effects and molecular mechanisms of quercetin in gynecological disorders

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 173, С. 116418 - 116418

Опубликована: Март 9, 2024

Quercetin is a representative flavonoid that widely present in fruits, herbs, and vegetables. It also an important active core component traditional Chinese medicines. As flavonoid, quercetin has various properties exerts antioxidant, anti-inflammatory, cardioprotective effects. The public interest increasing, been used to prevent or treat numerous of diseases, such as polycystic ovary syndrome (PCOS), cancer, autoimmune diseases chronic cardiovascular clinical experiments animal studies due its powerful antioxidant minimal side marked pharmacological effects on gynecological disorders; however, there have no reviews about the potential health benefits context disorders, including PCOS, premature failure (POF), endometriosis (EM), ovarian cancer (OC), cervical (CC) endometrial carcinoma (EC). Thus, this review aimed summarize biological disorders mechanisms.

Язык: Английский

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The effect of adipose-derived mesenchymal stem cell transplantation on ovarian mitochondrial dysfunction in letrozole-induced polycystic ovary syndrome in rats: the role of PI3K-AKT signaling pathway

Journal of Ovarian Research, Год журнала: 2024, Номер 17(1)

Опубликована: Апрель 27, 2024

Abstract Objective The present study aimed to elucidate how mesenchymal stem cells (MSCs) application could efficiently attenuate pathological changes of letrozole-induced poly cystic ovary syndrome (PCOS) by modulating mitochondrial dynamic via PI3K-AKT pathway. Methods Thirty-two female rats were randomly divided into four experimental groups: Sham, PCOS, PCOS + MSCs, and MSCs LY294002. Sham group received 0.5% w/v carboxymethyl cellulose (CMC); the letrozole (1 mg/kg, daily) in CMC for 21 days. Animals 1 × 10 6 MSCs/rat (i.p,) on 22th day study. In LY294002 group, (PI3K-AKT inhibitor) 40 min before MSC transplantation. Mitochondrial gene expression, membrane potential (MMP), citrate synthase (CS) activity, oxidative stress, inflammation, ovarian histological parameters, serum hormone levels, homeostatic model assessment insulin resistance (HOMA-IR), glucose concentrations, p-PI3K p-AKT protein levels evaluated at end experiment. Results showed a significant disruption dynamics changes, lower MMP, CS, super oxide dismutase (SOD) estrogen level. They also had notable rise HOMA-IR, testosterone level, tumor necrosis factor-α (TNF-α) interleukin-6 (IL-6) malondialdehyde (MDA) content as well decrease compared group. transplantation improve above parameters. Administration pathway deteriorated markers, stress status, inflammation hormonal glucose, follicular development Conclusions This demonstrated that protective effects regulating dynamics, promoting biogenesis, competing with redox status response mainly mediated through model.

Язык: Английский

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Network pharmacology uncovers that secoisolariciresinol diglucoside ameliorate premature ovarian insufficiency via PI3K/Akt pathway

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 9, 2025

As one of the essential lignan derivative found in traditional Chinese medicinal herbs, secoisolariciresinol diglucoside (SDG) was proved to promote women's health through its phytoestrogenic properties. Increasingly studies indicated that this compound could be a potential drug capable preventing estrogen-related diseases. Here, we aimed investigate whether SDG can counteract cyclophosphamide (CTX) induced premature ovarian insufficiency (POI) and further explore specific molecular mechanism. In study, first validated therapeutic effect on POI mouse model. Then, mechanism by which improves is predicted combination network pharmacology, authenticity confirmed experimental verification, docking analysis dynamics simulation. The results showed significantly alleviated improving indices follicle counts while protecting against CTX-induced damage modulating PI3K/Akt signaling pathway KGN cells. addition, SDG's high affinity for Akt1 PI3Kγ, pinpointing precise interaction sites. These underscore protective mechanisms damage, highlighting potential. summary, our study identified ameliorate with action intricately linked modulation pathway.

Язык: Английский

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Hyperoside mitigates PCOS-associated adipogenesis and insulin resistance by regulating NCOA2-mediated PPAR-γ ubiquitination and degradation

Life Sciences, Год журнала: 2025, Номер 364, С. 123417 - 123417

Опубликована: Янв. 27, 2025

Язык: Английский

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Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition

Open Medicine, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 1, 2025

Abstract Background and objective Early nutritional support holds paramount importance for postoperative gastric cancer (GC) patients. Peptidase M20 domain containing 1 (PM20D1) is a secretory enzyme associated with glucose lipid metabolism. However, there dearth of clinical studies delving into the connection between PM20D1, metabolism, inflammatory factors in GC patients who have received enteral nutrition (EN). This research aimed to investigate serum levels PM20D1 following early EN their potential associations markers, factors. Methods prospective observational study enrolled 180 May 2020 July 2022. On first day, all support, which was maintained duration 5 days. Serum interleukin (IL)-6, IL-1β, C-reactive protein were measured on sixth day after surgery using an enzyme-linked immunosorbent assay. Data demographics, statistics, parameters, prognostic index (PNI) collected. Patients followed up 12 months, both overall survival disease-free recorded. Results In low PNI group, albumin (ALB), blood lymphocytes (BL) showed significant reductions. Pearson analysis revealed negative correlation IL-6 levels, whereas positive emerged ALB BL levels. Furthermore, demonstrated as biomarker diagnosing poor status (PNI < 43) risk factor Conclusion remarkably declined status.

Язык: Английский

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Síndrome do ovário policístico: revisão sistemática de recentes pesquisas referentes à investigação de metabólitos secundários para o tratamento

Revista Fitos, Год журнала: 2025, Номер 19(1)

Опубликована: Фев. 1, 2025

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NAT10 mediated Polycystic ovary syndrome through the ac4C modification of CXCL14

The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2025, Номер unknown, С. 106767 - 106767

Опубликована: Апрель 1, 2025

Язык: Английский

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Transcriptomic signatures of WNT-driven pathways and granulosa cell-oocyte interactions during primordial follicle activation

PLoS ONE, Год журнала: 2024, Номер 19(10), С. e0311978 - e0311978

Опубликована: Окт. 23, 2024

Primordial follicle activation (PFA) is a pivotal event in female reproductive biology, coordinating the transition from quiescent to growing follicles. This study employed comprehensive single-cell RNA sequencing gain insights into detailed regulatory mechanisms governing synchronized dormancy and between granulosa cells (GCs) oocytes with progression of PFA process. Wntless ( Wls ) conditional knockout (cKO) mice served as unique model, suppressing pre-GCs GCs, disrupting somatic cell-derived WNT signaling ovary. Our data revealed immediate transcriptomic changes GCs post-PFA cKO mice, leading divergent trajectory, while exhibited modest alterations. Subpopulation analysis identified molecular pathways affected by on GC maturation, along specific gene signatures linked dormant activated oocytes. Despite minimal evidence continuous up-regulation dormancy-related genes oocytes, loss (pre-)GCs impacted expression even before PFA, subsequently influencing them globally. The infertility observed was attributed compromised GC-oocyte crosstalk microenvironment for highlights role WNT-signaling pathway its signature, emphasizing importance intercellular orchestrating folliculogenesis.

Язык: Английский

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Ghrelin Alleviates Inflammation, Insulin Resistance, and Reproductive Abnormalities in Mice with Polycystic Ovary Syndrome via the TLR4-NF-κB Signaling Pathway

Discovery Medicine, Год журнала: 2024, Номер 36(184), С. 946 - 946

Опубликована: Янв. 1, 2024

Polycystic ovary syndrome (PCOS) commonly impacts fertile females with potentially severe effects on fertility and metabolism. Blood ghrelin levels are lower in PCOS patients, exogenous supplements have been proposed for their potential to trigger anti-inflammatory at the cellular level. This study aimed investigate whether pretreatment reduced inflammation, insulin resistance, reproductive abnormalities underlying mechanism of this disorder.

Язык: Английский

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Ampelopsis japonica aqueous extract improves ovulatory dysfunction in PCOS by modulating lipid metabolism

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 170, С. 116093 - 116093

Опубликована: Дек. 29, 2023

Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine and metabolic disorder that closely associated with the proliferation apoptosis of ovarian granulosa cells (GCs). Ampelopsis japonica (AJ) dried tuberous root (Thunb.) Makino (A. japonica), anti-inflammatory, antioxidant, antibacterial, antiviral, wound-healing, antitumor properties; however, it unclear whether this herb has therapeutic effect on PCOS. Therefore, study aimed to investigate pharmacological AJ PCOS reveal its potential mechanism action. A rat model was established using letrozole. After establishing model, rats received oral treatment Diane-35 (Positive drug: ethinylestradiol + cyproterone tablets) for 2 weeks. Lipidomics conducted liquid-phase mass spectrometry chromatography. significantly regulated serum hormone levels attenuated pathological variants in ovaries Furthermore, reduced apoptotic rate GCs. Lipidomic analysis revealed modulated glycerolipid glycerophospholipid pathways mediated by lipoprotein lipase (Lpl), diacylglycerol choline phosphotransferase (Chpt1), choline/ethanolamine (Cept1). we may reduce GC modulating lipid metabolism, ultimately improving ovulatory dysfunction novel candidate treatment.

Язык: Английский

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