Network pharmacology and experimental validation to investigate the mechanism of Nao-Ling-Su capsule in the treatment of ischemia/reperfusion-induced acute kidney injury
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
326, С. 117958 - 117958
Опубликована: Фев. 22, 2024
Язык: Английский
Cornus officinalis Sieb. attenuates Aβ25-35-induced mitochondrial damage and neuroinflammation in mice by modulating the ERK pathway
Phytomedicine,
Год журнала:
2024,
Номер
129, С. 155709 - 155709
Опубликована: Май 3, 2024
Язык: Английский
Narciclasine attenuates sepsis-associated acute kidney injury through the ESR1/S100A11 axis
Functional & Integrative Genomics,
Год журнала:
2025,
Номер
25(1)
Опубликована: Янв. 14, 2025
Язык: Английский
Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 19, 2025
Acute
kidney
injury
(AKI)
represents
significant
medical
challenges
due
to
its
elevated
rates
of
morbidity
and
mortality,
with
limited
therapeutic
options
currently
available.
Hence,
the
exploration
novel
medicinal
treatments
for
AKI
management
remains
vital.
Substances
medicine
food
homology
(SMFH),
referring
substances
having
characteristics
both
medicine,
have
been
applied
in
China
thousands
years.They
could
be
used
daily
diets
body
conditioning.
Traditional
Chinese
(TCM),
naturally
derived
components
demonstrated
effectiveness,
presents
distinctive
benefits
treatment.
Numerous
studies
shown
that
SMFH
TCM
phytochemicals
function
satisfactorily
nephroprotective
effects
a
effect
on
alleviating
as
well
complications.
In
this
review,
pathogenesis
was
illustrated.
We
concentrated
against
tried
summarize
underlying
mechanisms
various
kinds
AKI,
highlighting
crucial
phytochemical
prevention
therapy.
Besides,
strategies
globalization
are
analysed.
This
review
comprehensively
reveals
exhibit
promising
potential
intervention
by
targeting
signal
pathways
targets,
which
would
contribute
AKI's
cognition,
preventive
treatments,
global
promotion.
Язык: Английский
Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis
Biology Direct,
Год журнала:
2025,
Номер
20(1)
Опубликована: Март 27, 2025
Acute
kidney
injury
(AKI)
remains
a
critical
condition
with
limited
therapeutic
options,
predominantly
managed
by
renal
replacement
therapy.
The
challenge
of
developing
targeted
treatments
persists.
We
integrated
genetic
data
related
to
druggable
proteins
and
gene
expression
AKI
genome-wide
association
study
(GWAS)
findings.
Based
on
multi-omics
Mendelian
randomization
(MR),
we
identified
the
potential
causal
influence
5,883
unique
genes
AKI.
also
performed
using
reverse
MR
external
cohort-based
analysis
verify
robustness
this
relationship.
Expression
patterns
these
targets
were
examined
bulk
transcriptome
single-cell
data.
In
addition,
drug
repurposing
analyses
conducted
explore
existing
medications.
constructed
molecular
interaction
network
interplay
between
known
drugs.
Genetically
predicted
levels
seven
twelve
associated
an
increased
risk
Of
these,
six
(NCF1,
TNFRSF1B,
APEH,
ACADSB,
ADD1,
FAM3B)
prioritized
based
robust
evidence
validated
in
independent
cohorts.
Reverse
showed
one-way
relationship
targets.
These
are
expressed
proximal
tubular
cells,
endothelial
collecting
duct-principal
immune
cells
within
both
AKI-affected
normal
tissues.
Several
promising
opportunities
identified,
such
as
telmisartan-NCF1,
calcitriol-ACADSB,
ethinyl
estradiol-ACADSB.
mapping
pathway
integration
provided
further
insights,
suggesting
strategies
for
combinatorial
therapies.
This
extensive
investigation
several
highlighted
repurposing.
findings
offer
valuable
insights
that
could
shape
future
research
development
treatments.
Язык: Английский
Pyroptosis in sepsis-associated acute kidney injury: mechanisms and therapeutic perspectives
Critical Care,
Год журнала:
2025,
Номер
29(1)
Опубликована: Апрель 23, 2025
Язык: Английский
Anti-sepsis effect of Xiaochaihu decoction based on the TLR4/MyD88/NF-κB signalling pathway
Heliyon,
Год журнала:
2024,
Номер
10(5), С. e26712 - e26712
Опубликована: Фев. 20, 2024
The
aims
of
this
study
were
to
explore
the
protective
effect
Xiaochaihu
decoction
in
mice
with
sepsis
induced
by
intraperitoneal
injection;
its
anti-inflammatory
on
TLR4-MyD88-NF-κB
signalling
pathway;
and
main
material
basis
decoction,
aim
supplementing
expanding
associated
research
providing
a
scientific
foundation
for
clinical
use
decoction.
effects
septic
analysed
measurements
white
blood
cells
(WBC)
Platelets
(PLT);
Nitric
Oxide
(NO)
level
serum;
IL-6,
IL-1β
TNF-α
levels
RT-PCR;
Haematoxylin-Eosin
(HE)
immunohistochemistry;
western
blotting
(WB).
results
showed
excellent
vivo
LPS-induced
mice,
through
down
regulation
gene
protein
expression
TLR4,
MYD88,
TRAF6,
IKK,
IKBα
p65
subsequent
reduction
release
inflammatory
mediators
IL-1β,
NO.
Moreover,
significant
anti-septic
was
observed
from
high
medium
doses
but
not
low
dose.
Язык: Английский
Chondroitin Sulfate from Halaelurus burgeri Skin Inhibits Hepatic Endoplasmic Reticulum Stress and Inflammation, and Regulates Gut Microbiota
Molecular Nutrition & Food Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 27, 2024
Scope
Previous
study
has
demonstrated
the
chemical
structure
of
chondroitin
sulfate
(CHS)
from
Halaelurus
burgeri
skin
and
its
effects
on
insulin
resistance.
However,
precise
impact
this
phenomenon
endoplasmic
reticulum
(ER)
stress
inflammation,
which
contribute
to
resistance,
remains
unclear.
This
is
investigate
CHS
ER
stress,
inflammatory
response
signaling,
gut
microbiota
in
high‐fat
diet
(HFD)‐fed
mice.
Methods
results
HFD‐fed
C57BL/6J
mice
receive
dietary
gavage
intervention
for
18
weeks.
Blood,
liver
tissue,
feces
are
harvested
further
investigation.
Results
show
that
inhibits
accompanied
by
lowered
blood
glucose,
nitric
oxide
(NO),
reactive
oxygen
(ROS),
free
fatty
acids
(FFA)
levels,
increases
hepatic
glycogen
accumulation.
Moreover,
inflammation
improved
treatment
via
inactivation
Toll‐like
receptor
4
(TLR4)
signaling
downstream
c‐jun
N‐terminal
kinase
(JNK)
nuclear
factor
kappa
B
(NFκB)
pathways.
Additionally,
regulates
microbiota,
particularly
decline
Firmicutes
Bacteroidetes
ratio.
also
lowers
fecal
lipopolysaccharide
elevates
several
short
chain
acids.
Conclusion
These
findings
suggest
H.
may
be
an
alternative
functional
food
supplement
anti‐ER
anti‐inflammtion,
regulation
microbiota.
Язык: Английский