Chemico-Biological Interactions, Год журнала: 2024, Номер 405, С. 111312 - 111312
Опубликована: Ноя. 17, 2024
Язык: Английский
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Март 18, 2024
The global challenge posed by cancer, marked rising incidence and mortality rates, underscores the urgency for innovative therapeutic approaches. PI3K/Akt signaling pathway, frequently amplified in various cancers, is central regulating essential cellular processes. Its dysregulation, often stemming from genetic mutations, significantly contributes to cancer initiation, progression, resistance therapy. Concurrently, ferroptosis, a recently discovered form of regulated cell death characterized iron-dependent processes lipid reactive oxygen species buildup, holds implications diseases, including cancer. Exploring interplay between dysregulated pathway ferroptosis unveils potential insights into molecular mechanisms driving or inhibiting ferroptotic cells. Evidence suggests that may sensitize cells induction, offering promising strategy overcome drug resistance. This review aims provide comprehensive exploration this interplay, shedding light on disrupting enhance as an alternative route inducing improving treatment outcomes.
Язык: Английский
Процитировано
21
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Фев. 14, 2024
In the past 11 years, there has been a surge in studies exploring regulatory effect of Traditional Chinese Medicine (TCM) on ferroptosis. However, significant gap persists comprehensive scientometric analysis and scientific mapping research, especially tracking evolution, primary contributors, emerging research focal points. This study aims to comprehensively update advancements targeting ferroptosis with various TCMs during previous years. The data, covering period from 1 January 2012, 30 November 2023, were retrieved Web Science database. For in-depth visualized analyses, series advanced analytical instruments employed. findings highlight China’s predominant role, accounting for 71.99% total publications significantly shaping this domain. Noteworthy productivity was observed at institutions, including Guangzhou University Medicine, Chengdu Zhejiang University. Thomas Efferth emerged as foremost author within field, while Frontiers Pharmacology boasted highest publication count. pinpointed hepatocellular carcinoma, chemical drug-induced liver injury, mitochondrial diseases, acute kidney failure most critical disorders addressed realm. offers bibliometric evaluation, enhancing our understanding present status TCM therapy managing ferroptosis-related diseases. Consequently, it aids both seasoned researchers newcomers by accelerating access vital information fostering innovative concept extraction specialized field.
Язык: Английский
Процитировано
10
ACS Omega, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Perfluorooctanoic acid (PFOA), a typical environmental contaminant, has been observed in tissue samples of various diseases, including liver cancer. PFOA can lead to hepatotoxicity, but the underlying molecular mechanism remains unclear. Our results showed that significantly inhibited HL-7702 (L02) and MIHA cell viability time- dose-dependent manner. Furthermore, could cause oxidative stress, mitochondrial injury, ferroptosis. In addition, upregulated levels malondialdehyde glutathione/oxidized glutathione downregulated expressions SLC7A11 GPX4, which refer phenotypes suppressed phosphorylation signaling cascades AKT/GSK3β/β-catenin, indicating signal pathway might be related order prove above hypothesis, Wnt activator chir99021 was used result revealed PFOA-induced inhibition p-AKT its downstream effectors p-GSK3β, SLC7A11, GPX4 counteracted. On other hand, inhibitor p-AKT, Ly294002, strengthened PFOA's regulatory actions on these factors. Overall, our suggest injury by inducing stress The effects are conferred through regulation AKT/GSK3β/β-catenin cascades.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135109 - 135109
Опубликована: Авг. 27, 2024
Язык: Английский
Процитировано
7
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Июль 26, 2024
Artesunate (ART), a natural product isolated from traditional Chinese plant Artemisia annua, has not been extensively explored for its anti-melanoma properties. In our study, we found that ART inhibited melanoma cell proliferation and induced ferroptosis. Mechanistic study revealed directly targets Ido1, thereby suppressing Hic1-mediated transcription suppression of Hmox1, resulting in CD8+ T cells, does cause ferroptosis due to the low expression Hmox1. It also elevating tryptophan levels, which inhibits NFATc1-mediated PD1 transcription, consequently activating cells. Our uncovered potent synergistic efficacy arising ART-induced concurrently enhancing cell-mediated immune response both vivo vitro through targeting Ido1. provides novel mechanistic basis utilization as an Ido1 inhibitor application clinical treatment.
Язык: Английский
Процитировано
5
Drug Resistance Updates, Год журнала: 2025, Номер unknown, С. 101238 - 101238
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Biology Direct, Год журнала: 2024, Номер 19(1)
Опубликована: Июль 23, 2024
Abstract Laryngeal carcinoma (LC) is a common cancer of the respiratory tract. This study aims to investigate role RNA-binding motif protein 15 (RBM15) in cisplatin (DDP) resistance LC cells. LC-DDP-resistant cells were constructed. RBM15, lysine-specific demethylase 5B (KDM5B), lncRNA Fer-1 like family member 4 (FER1L4), KCNQ1 overlapping transcript 1 (KCNQ1OT1), glutathione peroxidase (GPX4), and Acyl-CoA synthetase long-chain (ACSL4) was examined. Cell viability, IC 50 , proliferation assessed after RBM15 downregulation. The enrichment insulin-like growth factor 2 mRNA-binding 3 (IGF2BP3) N6-methyladenosine (m6A) on KDM5B analyzed. mRNA stability measured actinomycin D treatment. A tumor xenograft assay conducted verify LC. Results showed that upregulated its knockdown decreased cell proliferation, glutathione, iron ion content, ROS, malondialdehyde, ACSL4, ferroptosis. Mechanistically, improved an IGF2BP3-dependent manner, resulting FER1L4 downregulation GPX4 upregulation. increased KCNQ1OT1 inhibited ACSL4. KDM5B/KCNQ1OT1 overexpression or promoted DDP by inhibiting In conclusion, expression, upregulation ferroptosis downregulating upregulating GPX4, as well Silencing vivo.
Язык: Английский
Процитировано
4
Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 5985 - 6004
Опубликована: Сен. 1, 2024
Colorectal cancer (CRC), as the third most common bisexual worldwide, requires urgent research on its underlying mechanisms and intervention methods. NRF2 is an important transcription factor involved in regulation of redox homeostasis, protein degradation, DNA repair, other processes, playing role cancer. In recent years, complex CRC has been continuously revealed: one hand, it exhibits a chemopreventive effect by protecting normal cells from oxidative stress, also protective malignant cells. Therefore, this article explores dual related signaling pathways CRC, including their chemical properties promoting effects occurrence, development, metastasis, chemotherapy resistance CRC. addition, focuses exploring ferroptosis, well drug modulators (activators inhibitors) targeting natural products, compounds, traditional Chinese medicine formulations.
Язык: Английский
Процитировано
4
Xenobiotica, Год журнала: 2025, Номер unknown, С. 1 - 30
Опубликована: Фев. 11, 2025
The Nrf2 signaling pathway is crucial for cellular defense against oxidative stress and xenobiotic toxicity, highlighting its importance in both human health environmental responses.
Язык: Английский
Процитировано
0
Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119529 - 119529
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0