The
efficacy
of
deferiprone
(DFP)
in
reducing
liver
iron
content
is
still
inadequate.
Ethanolic
extract
Phaleria
macrocarpa
L.
(PM)
fruit
showed
chelation
activity
and
hepatoprotective
effects.
This
study
aimed
to
evaluate
the
combination
PM
reduce
liver.
Rats
were
divided
into
6
groups:
normal,
overload
(IO),
IO+DFP,
IO+PM
extract,
IO+PM+DFP
or
half
dose.
induced
with
iron-dextran
injections
over
8
weeks,
therapy
starting
from
week
4.
Measurements
included
hepatic
iron,
malondialdehyde
(MDA),
GSH,
TNF-α
levels,
GPx4
mRNA
expression,
plasma
ALT
AST
activity,
histopathology.
While
none
treatments
significantly
reduced
treatment
PM+DFP
dose
greatest
reduction
improved
MDA,
ALT,
AST,
levels
compared
DFP
monotherapy.
GSH
not
altered
by
therapy.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(22), С. 12340 - 12355
Опубликована: Май 22, 2024
Lipid
peroxidation
(LP)
leads
to
changes
in
the
fluidity
and
permeability
of
cell
membranes,
affecting
normal
cellular
function
potentially
triggering
apoptosis
or
necrosis.
This
process
is
closely
correlated
with
onset
many
diseases.
Evidence
suggests
that
phenolic
hydroxyl
groups
food-borne
plant
polyphenols
(FPPs)
make
them
effective
antioxidants
capable
preventing
diseases
triggered
by
membrane
LP.
Proper
dietary
intake
FPPs
can
attenuate
oxidative
stress,
especially
damage
phospholipids,
activating
Nrf2/GPx4
pathway.
Nuclear
factor
E2-related
2
(Nrf2)
an
stress
antagonist.
The
signaling
pathway
regulated
Nrf2
a
defense
transduction
organism
against
external
stimuli
such
as
reactive
oxygen
species
exogenous
chemicals.
Glutathione
peroxidase
4
(GPx4),
under
regulation
Nrf2,
only
enzyme
reduces
lipid
peroxides
specificity,
thus
playing
pivotal
role
regulating
ferroptosis
counteracting
stress.
study
explored
mechanism,
antioxidant
activity
FPPs,
mechanism
It
also
highlighted
bioprotective
properties
LP
its
associated
mechanisms,
including
(i)
activation
pathway,
GPx4
serving
central
target
protein,
(ii)
activities,
leading
reduction
production
ROS
other
peroxides,
(iii)
effects
on
downstream
phospholipid
structure.
In
conclusion,
play
crucial
natural
However,
further
in-depth
analysis
coregulation
multiple
pathways
required,
combined
these
mechanisms
need
evaluation
experimental
models.
Human
trials
could
provide
valuable
insights
into
new
directions
for
research
application.
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 2557 - 2581
Опубликована: Фев. 1, 2025
Ulcerative
colitis
is
a
chronic
intestinal
disease
linked
to
barrier
damage,
ferroptosis
and
dysbiosis.
Coix
lacryma-jobi
natural
food
with
food-medicine
homology,
whose
seed-derived
oil
(Coix
seed
oil,
CSO)
has
been
shown
anti-inflammatory
activity
in
vitro.
Here,
the
effects
mechanisms
of
CSO
on
ulcerative
(UC)
vivo
are
systematically
investigated.
Firstly,
UC
mice
was
replicated
by
3%
DSS,
assessed
efficacy
observing
fecal
occult
blood,
colon
length,
DAI
score
pathological
histomorphological
changes
tissues.
The
barrier-protective
were
observed
AB
staining
qRT-PCR.
Secondly,
biological
targets
obtained
from
TCMSP
database
Swiss
Target
Prediction
database,
downloaded
FerrDb
platform,
UC-related
GEO
intersection
above
three
taken
obtain
"CSO-UC-Ferroptosis"
targets,
which
analysed
GO
KEGG
enrichment,
GSEA
analysis,
immune
cell
infiltration
validation.
Finally,
core
genes
molecular
docking
potential
active
components
CSO.
In
order
further
verify
effect
ferroptosis,
GPX4
agonist
RSL-3
used
stimulate
vivo,
levels
Iron,
MDA
SOD
measured,
immunohistochemistry
detect
tight
junction
proteins
protein
mice.
Besides,
evaluated
intercellular
junctions
tissues
each
group
under
electron
microscope.
addition,
16sRNA
sequencing
performed
contents
observe
flora
improved
physiological
parameters,
reduced
inflammation
response
regulated
restored
gut
microbiota
balance
Bioinformatics
results
showed
that
G6PD,
ABCC1
at
CSO,
also
demonstrated
similar
expression
DSS-induced
models
vivo.
Our
findings
demonstrate
for
first
time
ameliorated
regulating
mice,
suggesting
as
promising
candidate
treatment
warranting
investigation.
Acta Biomaterialia,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Large
bone
defects,
often
arising
from
trauma
or
infection,
pose
a
considerable
therapeutic
challenge
due
to
their
limited
capacity
for
spontaneous
healing,
thus
requiring
graft
materials
effective
reparative
procedures.
The
persistence
of
inflammation
and
elevated
levels
reactive
oxygen
species
(ROS)
within
these
defect
sites
significantly
impede
regeneration
process.
Addressing
this,
an
injectable
hydrogel
system
with
ROS-responsive
functionality
is
developed,
specifically
tailored
the
high
ROS
microenvironment
characteristic
defects.
This
incorporates
hyaluronic
acid
functionalized
dopamine
introduce
catechol
moieties,
employs
4-formylphenylboronic
as
crosslinking
agent
form
dynamic
matrix
(HAC)
carboxymethyl
chitosan.
HAC
serves
carrier
dimethyl
fumarate
(DMF),
compound
established
anti-inflammatory
antioxidant
effects,
enabling
its
controlled
release
in
response
levels.
Herein,
we
investigated
physicochemical
properties
DMF
loaded
(DHAC)
by
microstructure
observation,
vitro
degradation
assay,
self-healing
test,
injectability
experiments,
drug
assay.
Meanwhile,
systematically
effects
on
inflammation,
intracellular
ROS,
osteogenesis.
Consequently,
DHAC
reduced
pro-inflammatory
cytokines
secreted
RAW264.7
cells
scavenged
MC3T3
cells.
effect
was
accompanied
augmentation
osteogenic
potential
promotion
repair
cranial
defects
rats.
DHAC,
which
exhibits
anti-inflammatory,
antioxidant,
activity,
hold
great
strategy
management
large
STATEMENT
OF
SIGNIFICANCE:
Here,
novel
fumarate-loaded
developed
treatment
Our
findings
demonstrated
that
not
only
promotes
but
also
controls
addressing
two
critical
challenges
healing.
Comprehensive
evaluations
show
significant
improvements
formation
reduction
animal
models.
Additionally,
excellent
scavenging
ability,
effectively
modulating
oxidative
stress
microenvironment.
Findings
suggest
may
serve
promising
clinical
critical-sized
