Effect of the combination of deferiprone with ethanolic extract of Phaleria macrocarpa L. fruit in overcoming iron excess in the liver of hemosiderosis model rats DOI Creative Commons
Rahma Rahma, Ari Estuningtyas,

Kusmardi Kusmardi

et al.

Pharmacia, Journal Year: 2024, Volume and Issue: 71, P. 1 - 14

Published: Dec. 19, 2024

The efficacy of deferiprone (DFP) in reducing liver iron content is still inadequate. Ethanolic extract Phaleria macrocarpa L. (PM) fruit showed chelation activity and hepatoprotective effects. This study aimed to evaluate the combination PM reduce liver. Rats were divided into 6 groups: normal, overload (IO), IO+DFP, IO+PM extract, IO+PM+DFP or half dose. induced with iron-dextran injections over 8 weeks, therapy starting from week 4. Measurements included hepatic iron, malondialdehyde (MDA), GSH, TNF-α levels, GPx4 mRNA expression, plasma ALT AST activity, histopathology. While none treatments significantly reduced treatment PM+DFP dose greatest reduction improved MDA, ALT, AST, levels compared DFP monotherapy. GSH not altered by therapy.

Language: Английский

Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects DOI Creative Commons

Qin Ru,

Yusheng Li,

Lin Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Language: Английский

Citations

50
Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway DOI
Mengmeng Zhang, Jingbo Liu,

Yiding Yu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(22), P. 12340 - 12355

Published: May 22, 2024

Lipid peroxidation (LP) leads to changes in the fluidity and permeability of cell membranes, affecting normal cellular function potentially triggering apoptosis or necrosis. This process is closely correlated with onset many diseases. Evidence suggests that phenolic hydroxyl groups food-borne plant polyphenols (FPPs) make them effective antioxidants capable preventing diseases triggered by membrane LP. Proper dietary intake FPPs can attenuate oxidative stress, especially damage phospholipids, activating Nrf2/GPx4 pathway. Nuclear factor E2-related 2 (Nrf2) an stress antagonist. The signaling pathway regulated Nrf2 a defense transduction organism against external stimuli such as reactive oxygen species exogenous chemicals. Glutathione peroxidase 4 (GPx4), under regulation Nrf2, only enzyme reduces lipid peroxides specificity, thus playing pivotal role regulating ferroptosis counteracting stress. study explored mechanism, antioxidant activity FPPs, mechanism It also highlighted bioprotective properties LP its associated mechanisms, including (i) activation pathway, GPx4 serving central target protein, (ii) activities, leading reduction production ROS other peroxides, (iii) effects on downstream phospholipid structure. In conclusion, play crucial natural However, further in-depth analysis coregulation multiple pathways required, combined these mechanisms need evaluation experimental models. Human trials could provide valuable insights into new directions for research application.

Language: Английский

Citations

14
MiR-370-3p regulate TLR4/SLC7A11/GPX4 to alleviate the progression of glucocorticoids-induced osteonecrosis of the femoral head by promoting osteogenesis and suppressing ferroptosis DOI Creative Commons

Rongtai Zuo,

Bojun Cao, Lingchi Kong

et al.

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Coix Seed Oil Alleviates DSS-Induced Ulcerative Colitis via Intestinal Barrier Repair and Ferroptosis Regulation DOI Creative Commons

Yi-Xuan Zeng,

N. Li,

Bing-Ying Deng

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 2557 - 2581

Published: Feb. 1, 2025

Ulcerative colitis is a chronic intestinal disease linked to barrier damage, ferroptosis and dysbiosis. Coix lacryma-jobi natural food with food-medicine homology, whose seed-derived oil (Coix seed oil, CSO) has been shown anti-inflammatory activity in vitro. Here, the effects mechanisms of CSO on ulcerative (UC) vivo are systematically investigated. Firstly, UC mice was replicated by 3% DSS, assessed efficacy observing fecal occult blood, colon length, DAI score pathological histomorphological changes tissues. The barrier-protective were observed AB staining qRT-PCR. Secondly, biological targets obtained from TCMSP database Swiss Target Prediction database, downloaded FerrDb platform, UC-related GEO intersection above three taken obtain "CSO-UC-Ferroptosis" targets, which analysed GO KEGG enrichment, GSEA analysis, immune cell infiltration validation. Finally, core genes molecular docking potential active components CSO. In order further verify effect ferroptosis, GPX4 agonist RSL-3 used stimulate vivo, levels Iron, MDA SOD measured, immunohistochemistry detect tight junction proteins protein mice. Besides, evaluated intercellular junctions tissues each group under electron microscope. addition, 16sRNA sequencing performed contents observe flora improved physiological parameters, reduced inflammation response regulated restored gut microbiota balance Bioinformatics results showed that G6PD, ABCC1 at CSO, also demonstrated similar expression DSS-induced models vivo. Our findings demonstrate for first time ameliorated regulating mice, suggesting as promising candidate treatment warranting investigation.

Language: Английский

Citations

1
Zearalenone induces liver injury in mice through ferroptosis pathway DOI

Lige Bao,

Yongze Huang,

Fuhua Gu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 952, P. 175875 - 175875

Published: Aug. 30, 2024

Language: Английский

Citations

5
Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles alleviates atherosclerosis by suppressing macrophage ferroptosis via the NRF2/SLC7A11/GPX4 pathway. DOI Creative Commons

Mengying Jin,

Xiaohong Chen, Lirong Zheng

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: 765, P. 110316 - 110316

Published: Jan. 22, 2025

Language: Английский

Citations

0
Research progress of cysteine transporter SLC7A11 in endocrine and metabolic diseases DOI

Jiaqi Chen,

Ming‐Long Yuan, Jianping Wang

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 3, 2025

Language: Английский

Citations

0
Advances in Ferroptosis and Glucocorticoid-Induced Osteonecrosis of Femoral Head and Discussion of Related Ferroptosis Genes in Bone Metabolism or Oxidative Stress DOI

绍庚 王

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 1717 - 1730

Published: Jan. 1, 2025

Language: Английский

Citations

0
Obacuone improves oxygen–glucose deprivation/reoxygenation-induced H9c2 cell damage by inhibiting ferroptosis DOI
Ling Gao,

Jianhai Chen

Molecular & Cellular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Language: Английский

Citations

0
ROS-Responsive Hydrogel for Bone Regeneration: Controlled Dimethyl Fumarate Release to Reduce Inflammation and Enhance Osteogenesis DOI Creative Commons

Qiuxia Huang,

Yang Qu,

Mengchen Tang

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Large bone defects, often arising from trauma or infection, pose a considerable therapeutic challenge due to their limited capacity for spontaneous healing, thus requiring graft materials effective reparative procedures. The persistence of inflammation and elevated levels reactive oxygen species (ROS) within these defect sites significantly impede regeneration process. Addressing this, an injectable hydrogel system with ROS-responsive functionality is developed, specifically tailored the high ROS microenvironment characteristic defects. This incorporates hyaluronic acid functionalized dopamine introduce catechol moieties, employs 4-formylphenylboronic as crosslinking agent form dynamic matrix (HAC) carboxymethyl chitosan. HAC serves carrier dimethyl fumarate (DMF), compound established anti-inflammatory antioxidant effects, enabling its controlled release in response levels. Herein, we investigated physicochemical properties DMF loaded (DHAC) by microstructure observation, vitro degradation assay, self-healing test, injectability experiments, drug assay. Meanwhile, systematically effects on inflammation, intracellular ROS, osteogenesis. Consequently, DHAC reduced pro-inflammatory cytokines secreted RAW264.7 cells scavenged MC3T3 cells. effect was accompanied augmentation osteogenic potential promotion repair cranial defects rats. DHAC, which exhibits anti-inflammatory, antioxidant, activity, hold great strategy management large STATEMENT OF SIGNIFICANCE: Here, novel fumarate-loaded developed treatment Our findings demonstrated that not only promotes but also controls addressing two critical challenges healing. Comprehensive evaluations show significant improvements formation reduction animal models. Additionally, excellent scavenging ability, effectively modulating oxidative stress microenvironment. Findings suggest may serve promising clinical critical-sized

Language: Английский

Citations

0