Gut microbiota-related neuroinflammation at the crossroad of food reward alterations: implications for eating disorders

Gut, Год журнала: 2025, Номер unknown, С. gutjnl - 333397

Опубликована: Фев. 17, 2025

The link between gut microbiome and eating behaviours, especially palatable food intake, is a growing focus of scientific investigation. complex ecosystem microorganisms in the influences host metabolism, immune function neurobehavioural signalling. This review explores role neuroinflammation dysregulations food-induced reward signalling potential causal microbiota on these proinflammatory processes. Particular attention given to disorders (ED, specifically anorexia nervosa, binge disorder bulimia nervosa) links with microbiota, alterations neuroinflammation. Finally, we propose modulation as promising therapeutic strategy ED.

Язык: Английский

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Mechanisms of weight regain.

European Journal of Internal Medicine, Год журнала: 2021, Номер 93, С. 3 - 7

Опубликована: Янв. 18, 2021

Язык: Английский

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Positive affect: nature and brain bases of liking and wanting

Current Opinion in Behavioral Sciences, Год журнала: 2021, Номер 39, С. 72 - 78

Опубликована: Март 9, 2021

Язык: Английский

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Obesity and Eating Disorders in Children and Adolescents: The Bidirectional Link

Nutrients, Год журнала: 2021, Номер 13(12), С. 4321 - 4321

Опубликована: Ноя. 29, 2021

Obesity, eating disorders and unhealthy dieting practices among children adolescents are alarming health concerns due to their high prevalence adverse effects on physical psychosocial health. We present the evidence that obesity can be managed or prevented using same interventions in pediatric age. In presence of age, disordered behaviors highly prevalent, increasing risk developing disorders. The most frequently observed subjects with bulimia nervosa binge-eating disorders, both which characterized by abnormal weight-control behaviors. Various mechanisms overlying interaction including environmental individual ones, different approaches reduce consequences. Evidence-based treatments for childhood include as first line weight loss nutritional management lifestyle modification via behavioral psychotherapy, well treatment psychiatric comorbidities if those not a consequence disorder. Drugs bariatric surgery need used extreme cases. Future research is necessary early detection factors prevention, more precise elucidation underpin these problems and, finally, cases requiring therapeutic intervention, provide tailored timely treatment. Collective efforts between fields crucial reducing disparity improving public

Язык: Английский

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Ultra-Processed Food, Reward System and Childhood Obesity

Children, Год журнала: 2023, Номер 10(5), С. 804 - 804

Опубликована: Апрель 29, 2023

Obesity and overweight are a major public health problem globally. Diet quality is critical for proper child development, an unhealthy diet preventable risk factor noncommunicable diseases (NCDs), such as obesity. Consumption of sugar-sweetened beverages ultra-processed foods (UPFs) in childhood may increase the BMI/BMI z-score, body fat percentage, or likelihood overweight. A strict feeding regulation system allows sufficient food to be consumed meet ongoing metabolic demands while avoiding overconsumption. This narrative review explores issues obesity intake related reward systems UPF consumption. Nutrient composition alone cannot explain influence UPFs on Furthermore, non-nutritional properties mechanisms underlying relationship with NCDs. designed highly palatable, appealing, energy dense unique combination main taste enhancer ingredients generate strong rewarding stimulus circuits facilitation. How individual eating behavior processes remains not fully elucidated. To knowledge between pediatric obesity, it useful limit rapid growth prevalence subsequent complications, develop new strategies appropriate nutrition policies.

Язык: Английский

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Children’s eating behaviours and related constructs: conceptual and theoretical foundations and their implications

International Journal of Behavioral Nutrition and Physical Activity, Год журнала: 2023, Номер 20(1)

Опубликована: Фев. 15, 2023

Abstract Background There is a substantial body of research on children’s eating behaviours (e.g., food responsiveness and fussiness) related constructs in the absence hunger, appetite self-regulation). This provides foundation for understanding dietary intakes healthy behaviours, as well efforts at intervention, whether relation to avoidance, overeating and/or trajectories excess weight gain. The success these their associated outcomes dependent theoretical conceptual clarity constructs. This, turn contributes coherence precision definitions measurement Limited areas ultimately creates uncertainty around interpretation findings from studies intervention programs. At present there does not appear be an overarching framework constructs, or separate domains behaviours/constructs. main purpose review was examine possible foundations some current questionnaire behavioural measures Methods We reviewed literature most prominent use with children aged ~ 0–12 years. focused explanations justifications original design included perspectives, interpretations (and difficulties) Results found that commonly used had relatively applied practical concerns rather than perspectives. Conclusions concluded, consistent Lumeng & Fisher (1), although existing have served field well, advance science, better contribute knowledge development, increased attention should directed Suggestions future directions are outlined.

Язык: Английский

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Uma Perspectiva Neurocientífica sobre a Obesidade na Infância e Adolescência e seus Impactos na Saúde da Coluna

Revista Científica de Salud y Desarrollo Humano, Год журнала: 2024, Номер 5(1), С. 107 - 125

Опубликована: Март 25, 2024

Introdução: A obesidade na infância e adolescência é um grave problema de saúde global. Tal fenômeno está associado a uma série consequências adversas, incluindo riscos para física emocional das crianças adolescentes. Este artigo científico visa explorar as conexões entre infantil, aspectos neurocientíficos problemas coluna. Objetivo: coluna não descorando os atributos genéticos. Metodologia: revisão bibliográfica, sobre infantil adolescência, segundo visão da neurociência Conclusão: Sendo assim, fundamental que ocorra prevenção educação escolhas alimentares saudáveis, promoção atividade regular conscientização população associados à obesidade.

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Defining Hyperphagia for Improved Diagnosis and Management of MC4R Pathway–Associated Disease: A Roundtable Summary

Current Obesity Reports, Год журнала: 2025, Номер 14(1)

Опубликована: Янв. 25, 2025

Hyperphagia is a condition associated with rare obesity-related diseases, presenting as pathologic, insatiable hunger accompanied by abnormal food-seeking behaviors. In October 2023, group of researchers and clinicians expert knowledge on hyperphagia convened at the annual ObesityWeek meeting to discuss need for unified definition key items necessary improve identification, assessment, treatment in patients melanocortin 4 receptor (MC4R) pathway-associated diseases. The proposed this Suggested methods accurately identify include increased physician parent/caregiver education standardized efficient screening procedures use clinic. etiology related MC4R signaling was also reviewed central cause across several underlying Given potential pathology, recommends that undergo genetic testing comprehensive weight-management strategies incorporating lifestyle pharmacotherapies targeted addressing hyperphagia.

Язык: Английский

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Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity

Nutrients, Год журнала: 2021, Номер 13(4), С. 1214 - 1214

Опубликована: Апрель 7, 2021

Gut-brain signaling controls food intake and energy homeostasis, its activity is thought to be dysregulated in obesity. We will explore new studies that suggest the endocannabinoid (eCB) system upper gastrointestinal tract plays an important role controlling gut-brain neurotransmission carried by vagus nerve of palatable other reinforcers. A focus on reveal both indirect direct interactions between eCB vagal afferent neurons. These investigations identify (i) mechanism nutrient-induced release peptides from gut epithelium directly interact with corresponding receptors neurons, (ii) a via eCBs cannabinoid expressed Moreover, impact diet-induced obesity these pathways considered.

Язык: Английский

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Food Preferences and Obesity

Endocrinology and Metabolism, Год журнала: 2021, Номер 36(2), С. 209 - 219

Опубликована: Апрель 19, 2021

Obesity is a multifactorial disease with several potential causes that remain incompletely understood. Recent changes in the environment, which has become increasingly obesogenic, have been found to interact individual factors. Evidence of role taste responsiveness and food preference obesity reported, pointing lower sensitivity higher intake fat and, lesser extent, sweet foods obese people. Studies last decades also suggested differences neurophysiology reward may lead overeating, contributing obesity. However, further studies are needed confirm these findings. In fact, only limited number conducted on large samples, were women. Larger balanced terms sex/gender age required order control confounding effect variables. As many factors intertwined obesity, multidisciplinary approach needed. This will allow better understanding alteration behaviours people design more effective strategies promote healthier eating prevent related chronic risks.

Язык: Английский

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