Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 479 - 479
Опубликована: Апрель 17, 2024
Antioxidant
peptides
are
a
class
of
biologically
active
with
low
molecular
weights
and
stable
antioxidant
properties
that
isolated
from
proteins.
In
this
review,
the
progress
in
research
on
activity
evaluation,
action
mechanism,
structure-activity
relationships
natural
summarized.
The
methods
used
to
evaluate
mainly
classified
into
three
categories:
vitro
chemical,
cellular,
vivo
animal
methods.
Also,
biological
effects
produced
by
these
listed:
scavenging
free
radicals,
chelation
metal
ions,
inhibition
lipid
peroxidation,
oxidative
enzyme
activities,
activation
enzymes
non-enzymatic
systems.
primarily
consist
regulation
redox
signaling
pathways,
which
includes
Nrf2
pathway
NF-κB
pathway.
investigated,
including
peptide
weight,
amino
acid
composition
sequence,
secondary
structure
activity.
addition,
four
computer-assisted
(molecular
docking,
dynamics
simulation,
quantum
chemical
calculations,
determination
quantitative
relationships)
for
analyzing
Thus,
review
lays
theoretical
foundation
development
new
antioxidants,
nutraceuticals,
cosmetics.
Advances in Nutrition,
Год журнала:
2025,
Номер
unknown, С. 100376 - 100376
Опубликована: Янв. 1, 2025
Aging
is
associated
with
the
decline
of
tissue
and
cellular
functions,
which
can
promote
development
age-related
diseases
like
cancer,
cardiovascular
disease,
neurodegeneration,
disorders
musculoskeletal
immune
systems.
Healthspan
length
time
an
individual
in
good
health
free
from
chronic
disabilities
aging.
Two
modifiable
factors
that
influence
healthspan,
healthy
aging,
prevent
diseases,
are
diet
microbiota
gastrointestinal
tract
(gut
microbiota).
This
review
will
discuss
how
dietary
phytochemicals
gut
work
concert
to
a
First
overview
provided
influences
aging
through
its
impact
on
barrier
integrity,
function,
mitochondria
function
oxidative
stress.
Next,
mechanisms
by
effect
health,
inflammation,
nurture
diverse
microbial
composition
discussed.
Lastly,
directly
producing
bioactive
metabolites
food
urolithin
A,
equol,
hesperetin
sulforaphane.
These
other
phytochemical
derived
may
healthspan
Importantly,
individual's
capacity
produce
promoting
cruciferous
vegetables,
berries,
nuts,
citrus
soy
products
be
dependent
specific
bacteria
present
gut.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2706 - 2706
Опубликована: Янв. 31, 2023
Coffee
is
one
of
the
most
widely
consumed
beverages
worldwide,
and
epidemiology
studies
associate
higher
coffee
consumption
with
decreased
rates
mortality
neurological
metabolic
diseases,
including
Parkinson's
disease
type
2
diabetes.
In
addition,
there
also
evidence
that
associated
lower
colon
rectal
cancer,
as
well
breast,
endometrial,
other
cancers,
although
for
some
these
results
are
conflicting.
These
reflect
chemopreventive
effects
coffee;
may
be
therapeutic
forms
breast
this
needs
to
further
investigated.
The
mechanisms
or
chemotherapeutic
over
1000
individual
compounds
in
roasted
complex
vary
different
diseases.
Some
related
nuclear
factor
erythroid
(Nrf2)-regulated
pathways
target
oxidative
stress
induce
reactive
oxygen
species
kill
diseased
cells
(primarily
therapeutic).
There
involvement
receptors
which
include
aryl
hydrocarbon
receptor
(AhR)
orphan
4A1
(NR4A1),
contributions
from
epigenetic
gut
microbiome.
Further
elucidation
will
facilitate
potential
future
clinical
applications
extracts
treating
cancer
inflammatory
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Авг. 1, 2024
Catechins,
a
class
of
phytochemicals
found
in
various
fruits
and
tea
leaves,
have
garnered
attention
for
their
diverse
health-promoting
properties,
including
potential
combating
neurodegenerative
diseases.
Among
these
catechins,
(-)-epigallocatechin-3-gallate
(EGCG),
the
most
abundant
polyphenol
green
tea,
has
emerged
as
promising
therapeutic
agent
due
to
its
potent
antioxidant
anti-inflammatory
effects.
Chronic
neuroinflammation
oxidative
stress
are
key
pathological
mechanisms
diseases
such
Alzheimer's
disease
(AD)
Parkinson's
(PD).
EGCG
neuroprotective
efficacy
scavenging
free
radicals,
reducing
attenuating
neuroinflammatory
processes.
This
review
discusses
molecular
EGCG's
anti-oxidative
chronic
neuroinflammation,
emphasizing
effects
on
autoimmune
responses,
neuroimmune
system
interactions,
focusing
related
AD
PD.
By
elucidating
action
impact
processes,
this
underscores
intervention
AD,
PD,
possibly
other
Overall,
emerges
natural
compound
stress,
offering
novel
avenues
strategies
treatment
disorders.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1098 - 1098
Опубликована: Янв. 27, 2025
This
article
reviews
the
synergistic
effects
of
antioxidant-enriched
functional
foods
and
exercise
in
improving
metabolic
health,
focusing
on
underlying
molecular
mechanisms.
The
review
incorporates
evidence
from
PubMed,
SCOPUS,
Web
Science,
PsycINFO,
reference
lists
relevant
up
to
20
December
2024,
highlighting
central
role
Nrf2
pathway.
As
a
critical
regulator
oxidative
stress
adaptation,
mediates
benefits
these
interventions.
presents
an
innovative
approach
understanding
regulation
inflammation,
its
potential
prevention
treatment
various
diseases,
including
cancer,
neurodegenerative
disorders,
cardiovascular
pulmonary
diabetes,
inflammatory
conditions,
ageing,
infections
such
as
COVID-19.
novelty
this
study
is
investigate
bioactive
compounds
found
(such
polyphenols,
flavonoids,
vitamins)
exercise-induced
activation
combined
reveals
their
improve
insulin
sensitivity
lipid
metabolism
reduce
offering
promising
strategy
for
management
chronic
diseases.
However,
there
are
significant
gaps
current
research,
particularly
regarding
mechanisms
interaction
between
diet,
physical
activity,
activation,
well
long-term
different
populations,
those
with
In
addition,
interactions
other
signalling
pathways,
AMPK,
NF-κB,
PI3K/Akt,
collective
contributions
health
explored.
Furthermore,
novel
biomarkers
presented
assess
impact
strategies,
NAD+/NADH
ratio,
GSH
markers
mitochondrial
health.
findings
provide
valuable
insights
into
how
integration
antioxidant-rich
diet
regular
can
by
activating
related
pathways
represent
strategies
disorders.
Further
studies
needed
fully
understand
therapeutic
interventions
diseases
stress,
disease,
cancer.
