Health Benefits of Quercetin in Age-Related Diseases

Molecules, Год журнала: 2022, Номер 27(8), С. 2498 - 2498

Опубликована: Апрель 13, 2022

Polyphenols are the known group of phytochemicals that essentially consists phenolic rings. These plant product present in varied fruits and vegetables. secondary metabolites perform a protective function plants from environmental biological stress. When consumed as human diet these also to prevent various age-associated diseases. possess antioxidant properties protect against oxidative The literature survey was carried out using databases such PubMed, Science direct Springer. research articles last 10-12 years were selected for this review based on its relevancy with topic. mainly focused quercetin health benefits. highlights main functions flavonoid, quercetin. Quercetin is among widely occurring polyphenol, found abundantly nature. It commonly different products. Onion have highest quantity This compound possessed considered aging. be both free conjugated forms. has anti-oxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, anti-viral properties. molecule lipophilic can easily cross BBB (Blood-Brain Barrier) hence protects neurodegenerative Various vivo vitro studies demonstrated role here detailed curative agent neurodegeneration, diabetes, cancer, inflammation been out. Studies proved plays crucial prevention age-related disorders. potent which currently being used pharmaceuticals. Properties further explored other Nanoformulations liposomal formulations made treat age associated

Язык: Английский

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Bioactivity and Therapeutic Potential of Kaempferol and Quercetin: New Insights for Plant and Human Health

Plants, Год журнала: 2022, Номер 11(19), С. 2623 - 2623

Опубликована: Окт. 5, 2022

Plant secondary metabolites, especially flavonoids, are major metabolites widely found in plants that play several key roles plant defence and signalling response to stress conditions. The most studied among these flavonoids kaempferol quercetin due their anti-oxidative potential the system, making them more critical for adaptation environments. Kaempferol have great therapeutic human health. Despite being well-studied, some of functional aspects regarding health need further evaluation. This review summarizes emerging terms antimicrobial activity, bioavailability bioactivity body as well regulation stresses a molecule hormonal modulation under We also evaluated safe use both pharmaceutical industry.

Язык: Английский

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Promising bioactive properties of quercetin for potential food applications and health benefits: A review

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Ноя. 30, 2022

Naturally occurring phytochemicals with promising biological properties are quercetin and its derivatives. Quercetin has been thoroughly studied for antidiabetic, antibacterial, anti-inflammatory, anti-Alzheimer's, anti-arthritic, antioxidant, cardiovascular, wound-healing properties. Anticancer activity of against cancer cell lines also recently revealed. The majority the Western diet contains derivatives, therefore consuming them as part a meal or food supplement may be sufficient people to take advantage their preventive effects. Bioavailability-based drug-delivery systems have heavily studied. Fruits, seeds, vegetables, bracken fern, coffee, tea, other plants all contain quercetin, do natural colors. One naturally antioxidant is whose anticancer effects discussed in detail. It several that could make it an effective anti-cancer agent. Numerous researches shown plays substantial suppression cells breast, colon, prostate, ovary, endometrial, lung tumors. current study includes concise explanation quercetin's action mechanism potential health applications.

Язык: Английский

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Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review

Nutrients, Год журнала: 2022, Номер 14(17), С. 3519 - 3519

Опубликована: Авг. 26, 2022

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin received the most attention among these molecules due to their documented antioxidant effects. The review aims investigate effects of on bone metabolism role in several diseases such as osteopenia osteoporosis, tumours, periodontitis. PubMed/Medline, Web Science, Google Scholar, Scopus, Cochrane Library, Embase electronic databases were searched for papers line with study topic. According an English language restriction, screening period was from January 2012 3 July 2022, following Boolean keywords: (“resveratrol” AND “bone”); (“curcumin” (“quercetin” “bone”). A total 36 identified relevant purpose our investigation. studies positive investigated phenolic potential application adjuvant treatments Furthermore, use titanium surfaces orthopaedic prostheses could represent a possible improve osteogenic processes osseointegration. findings, resveratrol, wide variety beneficial supplement therapies. seem positively mediate osteoclast-related pathologies.

Язык: Английский

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The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

Frontiers in Immunology, Год журнала: 2023, Номер 13

Опубликована: Фев. 2, 2023

Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and oxidative stress play important roles in various complex mechanisms IS. In particular, early proinflammatory response resulting from overactivation resident microglia infiltration circulating monocytes macrophages brain after cerebral ischemia leads to secondary injury. Microglia are innate immune cells that constantly monitor microenvironment under normal conditions. Once occurs, activated produce dual effects neurotoxicity neuroprotection, balance two determines fate damaged neurons. The activation defined as classical (M1 type) or alternative (M2 type). M1 type secrete pro-inflammatory cytokines neurotoxic mediators exacerbate neuronal damage, while M2 promote a repairing anti-inflammatory response. Fine regulation M1/M2 microglial minimize damage maximize protection has therapeutic value. This review focuses on interaction between other involved IS phenotypic characteristics, mechanism natural plant components regulating IS, providing novel candidate drugs for drug development.

Язык: Английский

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Advances in the study of the function and mechanism of the action of flavonoids in plants under environmental stresses

Planta, Год журнала: 2023, Номер 257(6)

Опубликована: Май 3, 2023

Язык: Английский

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Preparation and characterization of lotus root starch based bioactive edible film containing quercetin-encapsulated nanoparticle and its effect on grape preservation

Carbohydrate Polymers, Год журнала: 2023, Номер 323, С. 121389 - 121389

Опубликована: Сен. 12, 2023

Язык: Английский

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Recent Advances in Nanoformulations for Quercetin Delivery

Pharmaceutics, Год журнала: 2023, Номер 15(6), С. 1656 - 1656

Опубликована: Июнь 5, 2023

Quercetin (QUE) is a flavonol that has recently received great attention from the research community due to its important pharmacological properties. However, QUE's low solubility and extended first-pass metabolism limit oral administration. This review aims present potential of various nanoformulations in development QUE dosage forms for bioavailability enhancement. Advanced drug delivery nanosystems can be used more efficient encapsulation, targeting, controlled release QUE. An overview primary nanosystem categories, formulation processes, characterization techniques are described. In particular, lipid-based nanocarriers, such as liposomes, nanostructured-lipid carries, solid-lipid nanoparticles, widely improve absorption increase antioxidant activity, ensure sustained release. Moreover, polymer-based nanocarriers exhibit unique properties improvement Absorption, Distribution, Metabolism, Excretion, Toxicology (ADME(T)) profile. Namely, micelles hydrogels composed natural or synthetic polymers have been applied formulations. Furthermore, cyclodextrin, niosomes, nanoemulsions proposed alternatives administration via different routes. comprehensive provides insight into role advanced

Язык: Английский

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Flavonoids improve type 2 diabetes mellitus and its complications: a review

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Май 31, 2023

The prevalence of type 2 diabetes mellitus (T2DM) is increasing every year. Medications are currently the most common therapy for T2DM. However, these medications have certain adverse effects. In order to find safe and effective ways improve this disease, researchers discovered that some natural products can decrease blood sugar. Flavonoids one essential low molecular weight phenolic chemicals in plant world, which widely exist roots, stems, leaves, flowers, fruits. They possess a variety biological activities, including organ protection, hypoglycemic, lipid-lowering, anti-oxidative anti-inflammatory Some flavonoids ameliorate T2DM its complications through anti-oxidation, action, glucose lipid metabolism regulation, insulin resistance management, etc. Hence, review aims at demonstrating potential benefits complications. This laid foundation development novel hypoglycemic from flavonoids.

Язык: Английский

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Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Antioxidants, Год журнала: 2024, Номер 13(4), С. 393 - 393

Опубликована: Март 25, 2024

The aging of the global population has increased prevalence neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic quercetin, demonstrates potential for brain health. Limited research been conducted on therapeutic applications BM in This systematic review aims to project BM’s beneficial role disorders. anti-apoptotic antioxidant actions can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, increase neuroprotection. included twenty-two clinical trials demonstrated that reduce Nuclear Factor-κB phosphorylation, emotional cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, psychiatric problems. Moreover, levels pro-inflammatory biomarkers oxidative stress. Here, we highlight provides notable benefits serve a complementary approach care patients conditions associated adds growing interest natural products their by improving our understanding mechanisms underlying function neurodegeneration informing development new strategies diseases.

Язык: Английский

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