Journal of Biomedical Materials Research Part A,
Год журнала:
2024,
Номер
112(12), С. 2110 - 2123
Опубликована: Июнь 18, 2024
Increasing
bone
diseases
and
anomalies
significantly
challenge
regeneration,
necessitating
the
development
of
innovative
implantable
devices
for
effective
healing.
This
study
explores
potential
3D-printed
calcium
phosphate
(CaP)
scaffolds
functionalized
with
natural
medicine
to
address
this
issue.
Specifically,
quercetin
vitamin
D3
(QVD)
encapsulated
solid
lipid
nanoparticles
(QVD-SLNs)
are
incorporated
into
scaffold
enhance
regeneration.
The
melt
emulsification
method
is
utilized
achieve
high
drug
encapsulation
efficiency
(~98%)
controlled
biphasic
release
kinetics.
process-structure-property
performance
these
systems
allows
more
while
maintaining
healthy
cell-material
interactions.
show
~1.3-
~-1.6-fold
increase
in
osteoblast
cell
proliferation
differentiation,
respectively,
as
compared
control.
treated
demonstrates
a
reduction
osteoclastic
activity
QVD-SLN-loaded
~4.2-fold
vitro
chemopreventive
against
osteosarcoma
cells.
Bacterial
assessment
both
Staphylococcus
aureus
Pseudomonas
aeruginosa
shows
significant
bacterial
colony
growth
over
scaffold.
These
findings
summarize
that
QVD-SLNs
through
CaP
can
treat
various
bone-related
disorders
low
or
non-load-bearing
applications.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
168, С. 115653 - 115653
Опубликована: Окт. 7, 2023
The
modulation
of
microglial
polarization
from
the
pro-inflammatory
M1
to
anti-inflammatory
M2
phenotype
shows
promise
as
a
therapeutic
strategy
for
ischemic
stroke.
Quercetin,
natural
flavonoid
abundant
in
various
plants,
possesses
anti-inflammatory,
anti-apoptotic,
and
antioxidant
properties.
Nevertheless,
its
effect
underlying
mechanism
on
microglia/macrophages
M1/M2
treatment
cerebral
ischemia/reperfusion
injury
(CI/RI)
remain
poorly
explored.
In
current
study,
we
observed
that
quercetin
ameliorated
neurological
deficits,
reduced
infarct
volume,
decreased
number
(CD16/32+/Iba1+),
enhanced
(CD206+/Iba1+)
after
establishing
CI/RI
model
rats.
Subsequent
vivo
vitro
experiments
indicated
downregulated
markers
(CD86,
iNOS,
TNF-α,
IL-1β,
IL-6)
upregulated
(CD206,
Arg-1,
IL-10,
TGF-β).
Network
pharmacology
analysis
molecular
docking
revealed
PI3K/Akt/NF-κB
signaling
pathway
emerged
core
pathway.
Western
blot
confirmed
phosphorylation
PI3K
Akt,
while
alleviating
IκBα
NF-κB
both
vitro.
However,
inhibitor
LY294002
reversed
effects
expression
key
proteins
primary
microglia
oxygen-glucose
deprivation/reoxygenation
(OGD/R)
Collectively,
our
findings
demonstrate
facilitates
by
modulating
CI/RI.
These
provide
novel
insights
into
mechanisms
Beni-Suef University Journal of Basic and Applied Sciences,
Год журнала:
2023,
Номер
12(1)
Опубликована: Май 15, 2023
Abstract
Background
Flavonols
are
phytoconstituents
of
biological
and
medicinal
importance.
In
addition
to
functioning
as
antioxidants,
flavonols
may
play
a
role
in
antagonizing
diabetes,
cancer,
cardiovascular
disease,
viral
bacterial
diseases.
Quercetin,
myricetin,
kaempferol,
fisetin
the
major
dietary
flavonols.
Quercetin
is
potent
scavenger
free
radicals,
providing
protection
from
radical
damage
oxidation-associated
Main
body
abstract
An
extensive
literature
review
specific
databases
(e.g.,
Pubmed,
google
scholar,
science
direct)
were
conducted
using
keywords
“flavonol,”
“quercetin,”
“antidiabetic,”
“antiviral,”
“anticancer,”
“myricetin.”
Some
studies
concluded
that
quercetin
promising
antioxidant
agent
while
kaempferol
could
be
effective
against
human
gastric
cancer.
addition,
prevents
apoptosis
pancreatic
beta-cells
via
boosting
function
survival
rate
beta-cells,
leading
increased
insulin
secretion.
also
show
potential
alternatives
conventional
antibiotics,
restricting
infection
by
envelope
proteins
block
entry.
Short
conclusion
There
substantial
scientific
evidence
high
consumption
associated
with
reduced
risk
cancer
coronary
diseases,
alleviation,
tumor
growth
prevention,
secretion
improvement,
among
other
diverse
health
benefits.
Nevertheless,
more
required
determine
appropriate
concentration,
dose,
type
flavonol
for
particular
condition
prevent
any
adverse
side
effects.
Nano TransMed,
Год журнала:
2024,
Номер
3, С. 100030 - 100030
Опубликована: Янв. 6, 2024
Delayed
wound
healing
brings
additional
physical,
mental,
and
financial
burdens.
Microneedles
(MNs)
are
a
novel
dressing
form
can
incorporate
drug
delivery
systems.
Quercetin
is
known
for
its
remarkable
antioxidant
capacity
may
have
distinctive
effect
on
healing.
We
designed
constructed
gelatin
methacryloyl
(GelMa)
MNs
carrying
(Q-MNs).
In
vitro,
the
physical
properties,
cell
safety,
migration,
angiogenesis,
collagen
formation,
oxidative
stress
levels,
were
performed
to
characterize
Q-MNs.
vivo,
full-thickness
skin
models
established
evaluate
re-epithelialization
impact
of
control,
MN,
Q-MN
groups.
The
Q-MNs
mechanically
strong
enough
penetrate
sustained
possessed
good
biocompatibility.
Moreover,
evidently
facilitated
both
in
vitro
promoted
formation
neo-angiogenesis,
reduction
levels.
could
motivate
with
enhanced
vascularization
decreased
thus
providing
feasible
strategy
Phytotherapy Research,
Год журнала:
2024,
Номер
38(5), С. 2198 - 2214
Опубликована: Фев. 27, 2024
Abstract
Quercetin
is
the
most
common
polyphenolic
flavonoid
present
in
fruits
and
vegetables
demonstrating
versatile
health‐promoting
effects.
This
study
aimed
to
examine
effects
of
quercetin
(QR)
sclareol
(SCL)
on
thiopental
sodium
(TS)‐induced
sleeping
forced
swimming
test
(FST)
mouse
models.
SCL
(1,
5,
10
mg/kg,
p.o
.)
or
QR
(50
p.o.)
and/or
diazepam
(DZP)
(3
i.p.)
were
employed.
After
30
min
TS
induction,
individual
combined
animals
checked.
In
FST
test,
subjected
after
administration
controls
for
5
min.
this
case,
immobility
time
was
measured.
silico
studies
conducted
evaluate
involvement
GABA
receptors.
(5
mg/kg)
significantly
increased
latency
decreased
compared
control
TS‐induced
study.
DZP
showed
a
sedative‐like
effect
both
studies.
exhibited
similar
pattern
activity
as
SCL.
However,
its
more
prominent
than
those
groups.
(10
altered
DZP‐3‐mediated
SCL‐10
co‐treated
with
QR‐50
(
p
<
0.05)
sleep
time,
suggesting
possible
synergistic
antidepressant‐like
revealed
that
demonstrated
better
binding
affinities
GABAA
receptor,
especially
α
2
,
3
subunits.
Both
compounds
also
good
ADMET
drug‐like
properties.
animal
studies,
worked
synergistically
provide
slightly
different
fashion.
As
conclusion,
may
be
used
upcoming
neurological
clinical
trials,
according
vivo
findings.
additional
investigation
necessary
verify
behavior
clarify
potential
mechanism
action.
Food Reviews International,
Год журнала:
2025,
Номер
unknown, С. 1 - 50
Опубликована: Янв. 4, 2025
Cancer
is
the
world's
second
most
common
cause
of
death,
with
colon
cancer
(CC)
ranking
third
in
prevalence
and
cancer-related
fatalities.
CC
originates
or
rectum
influenced
by
genetic
mutations,
lifestyle,
diet.
Although
chemotherapy,
especially
5-fluorouracil
(5-FU),
fundamental
to
treatment
has
improved
patient
survival,
its
benefits
are
often
limited
significant
side
effects
emerging
drug
resistance.
Recently,
plant-based
foods
have
drawn
interest
research
for
their
natural
bioactive
compounds
relatively
low
toxicity.
Certain
plant
not
only
exhibit
anti-cancer
activity
but
may
also
boost
effectiveness
5-FU
while
reducing
adverse
effects.
Despite
evidence
suggesting
a
synergistic
effect
between
5-FU,
this
area
remains
fragmented.
This
review
consolidates
current
on
including
fruits,
vegetables,
legumes,
tea
bioactives
treatment.
Besides,
it
explores
mechanisms
through
which
these
enhance
efficacy
reduce
effects,
evaluates
clinical
application
prospects,
identifies
challenges
future
directions.
comprehensive
analysis
aims
provide
scientific
foundation
integrated
CC,
highlighting
potential
enhancing
chemotherapy
associated
toxicities.
Cancers,
Год журнала:
2023,
Номер
15(11), С. 3037 - 3037
Опубликована: Июнь 2, 2023
Prostate
cancer
is
the
second
most
common
in
men
worldwide.
can
be
treated
by
surgery
or
active
surveillance
when
early
diagnosed
but,
at
an
advanced
metastatic
stage,
radiation
therapy
androgen-deprivation
needed
to
reduce
progression.
However,
both
of
these
therapies
cause
prostate
resistance
treatment.
Several
studies
demonstrated
that
oxidative
stress
involved
occurrence,
development,
progression
and
treatment
resistance.
The
nuclear
factor
erythroid
2-related
2
(NRF2)/KEAP1
(Kelch-Like
ECH-Associated
Protein
1)
pathway
plays
important
role
protecting
cells
against
damage.
Reactive
oxygen
species
(ROS)
levels
NRF2
activation
determine
cell
fate.
In
particular,
toxic
ROS
lead
physiological
death
tumor
suppression,
while
lower
are
associated
with
carcinogenesis
On
contrary,
a
high
level
promotes
survival
related
activating
adaptive
antioxidant
response.
this
review,
we
analyzed
current
literature
regarding
natural
synthetic
compounds
modulating
NRF2/KEAP1
signaling
cancer.
GeroScience,
Год журнала:
2024,
Номер
46(6), С. 6473 - 6510
Опубликована: Июль 4, 2024
Abstract
This
review
provides
a
comprehensive
synthesis
of
longitudinal
observational
and
interventional
studies
on
the
cardiometabolic
effects
coffee
consumption.
It
explores
biological
mechanisms,
clinical
policy
implications,
highlights
gaps
in
evidence
while
suggesting
future
research
directions.
also
reviews
causal
relationships
between
consumption
outcomes
from
Mendelian
randomization
(MR)
studies.
Findings
indicate
that
may
cause
short-term
increases
blood
pressure,
it
does
not
contribute
to
long-term
hypertension
risk.
There
is
limited
indicating
intake
might
reduce
risk
metabolic
syndrome
non-alcoholic
fatty
liver
disease.
Furthermore,
consistently
linked
with
reduced
risks
type
2
diabetes
(T2D)
chronic
kidney
disease
(CKD),
showing
dose-response
relationships.
The
relationship
cardiovascular
complex,
potential
stroke
prevention
benefits
but
ambiguous
coronary
heart
Moderate
consumption,
typically
ranging
1
5
cups
per
day,
failure,
its
impact
atrial
fibrillation
remains
inconclusive.
associated
lower
all-cause
mortality,
following
U-shaped
pattern,
largest
reduction
observed
at
moderate
levels.
Except
for
T2D
CKD,
MR
do
robustly
support
link
adverse
outcomes.
beneficial
health
are
consistent
across
age,
sex,
geographical
regions,
subtypes
multi-dimensional,
involving
antioxidative,
anti-inflammatory,
lipid-modulating,
insulin-sensitizing,
thermogenic
effects.
Based
fundamental
processes
involved
aging,
has
extending
healthspan
increasing
longevity.
findings
underscore
need
understand
underlying
mechanisms
refine
recommendations
regarding
