Glycolipid Metabolic Disorders, Metainflammation, Oxidative Stress, and Cardiovascular Diseases: Unraveling Pathways

Biology, Год журнала: 2024, Номер 13(7), С. 519 - 519

Опубликована: Июль 12, 2024

Glycolipid metabolic disorders (GLMDs) are various resulting from dysregulation in glycolipid levels, consequently leading to an increased risk of obesity, diabetes, liver dysfunction, neuromuscular complications, and cardiorenal vascular diseases (CRVDs). In patients with GLMDs, excess caloric intake a lack physical activity may contribute oxidative stress (OxS) systemic inflammation. This study aimed review the connection between GLMD, OxS, metainflammation, onset CRVD. GLMD is due causing dysfunction synthesis, breakdown, absorption glucose lipids body, excessive ectopic accumulation these molecules. mainly neuroendocrine dysregulation, insulin resistance, metainflammation. many inflammatory markers defense cells play vital role related tissues organs, such as blood vessels, pancreatic islets, liver, muscle, kidneys, adipocytes, promoting lesions that affect interconnected organs through their signaling pathways. Advanced glycation end products, ATP-binding cassette transporter 1, Glucagon-like peptide-1, Toll-like receptor-4, sphingosine-1-phosphate (S1P) crucial since they glucolipid metabolism. The consequences this system organ damage morbidity mortality.

Язык: Английский

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Advances in functional lipid nanoparticles: from drug delivery platforms to clinical applications

3 Biotech, Год журнала: 2024, Номер 14(2)

Опубликована: Янв. 29, 2024

Язык: Английский

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Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Янв. 22, 2025

Post-stroke cognitive impairment (PSCI) is a common complication following stroke that significantly affects patients’ quality of life and rehabilitation outcomes. It also imposes heavy economic burden. There an urgent need to better understand the pathophysiology pathogenesis PSCI, as well identify markers can predict PSCI early in clinical stage, facilitating prevention, monitoring, treatment. Although mechanisms underlying are complex multifaceted, involving factors such atherosclerosis neuroinflammation, metabolic disorders play critical role. This article primarily reviews relationship between three major nutrients—sugar, fat, protein—and development dysfunction ischemic (IS). aims elucidate how these disturbances contribute post-stroke explore potential biomarkers for PSCI. We believe this review will offer new insights into identification, treatment, prognostic assessment

Язык: Английский

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Targeting lipid metabolism of macrophages: A new strategy for tumor therapy

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Фев. 1, 2024

Lipid metabolism has been implicated in a variety of normal cellular processes and strongly related to the development multiple diseases, including tumor. Tumor-associated macrophage (TAM) emerged as crucial regulator tumorigenesis promising target for tumor treatment.

Язык: Английский

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Comprehensive assessment of the anti-obesity effects of highland barley total, insoluble, and soluble dietary fiber through multi-omics analysis

Food Research International, Год журнала: 2024, Номер 189, С. 114535 - 114535

Опубликована: Май 21, 2024

Язык: Английский

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Roles of Gut Microbiota Metabolites and Circadian Genes in the Improvement of Glucose and Lipid Metabolism in KKAy Mice by Theabrownin

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер 73(9), С. 5260 - 5273

Опубликована: Фев. 18, 2025

Theabrownin (TB), a prominent pigment in fermented dark tea, exhibits beneficial effects on adiposity reduction. Our study revealed that TB derived from Fu brick tea significantly lowered fasting blood glucose levels and insulin resistance obese/diabetic KKAy mice. Furthermore, demonstrated potent anti-inflammatory the liver, adipose tissue, intestines, as well enhancing intestinal integrity. Additionally, was found to inhibit hepatic gluconeogenesis promote fatty acid oxidation. Notably, altered gut metabolites, particularly l-palmitoylcarnitine, which showed an elevation serum, tissue following intervention. l-Palmitoylcarnitine reduced primary hepatocytes decreased lipid deposition both 3T3-L1 adipocytes vitro. However, these were abolished when circadian gene Period 3 (Per3) knocked down. findings suggest l-palmitoylcarnitine may play crucial role improving TB-mediated homeostasis metabolism by regulating Per3.

Язык: Английский

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Per- and polyfluoroalkyl substances induce lipid metabolic impairment in fish: Integration on field investigation and laboratory study

Environment International, Год журнала: 2024, Номер 187, С. 108687 - 108687

Опубликована: Апрель 23, 2024

The biotoxicity of perfluoroalkyl and polyfluoroalkyl substances (PFASs) to aquatic organisms has been widely concerned. However, studies on toxic effects PFASs are usually evaluated directly by using laboratory exposure rather than validation based data obtained in the field. In this study, wild catfish (Silurus meridinalis) was explored relationship between bioaccumulation lipid disorders. Nine thirteen metabolites were significantly associated with perfluorooctane sulfonate (PFOS) 6:2/8:2Cl-PFESA (trade name F-53B) exposures, respectively; correlated fatty acid (FA) conjugates, FA esters, steroids, glycerophosphate subclasses. metabolism fish its mechanism further analyzed through experiments. Zebrafish (Danio rerio) different sexes underwent PFOS F-53B exposures for 21 days at 100 ng/L μg/L. By determining gene expression levels, hepatic contents, histopathological change, adverse order male or female μg/L/F-53(−|-)B > μg/L ng/L/F-53(−|-)B PFOS; stress response more intensive that female. activated peroxisome proliferator-activated receptor pathway, promoting processes total cholesterol (T-CHO) transport, β-oxidation, synthesis, finally induced T-CHO transportation from blood into liver, then accelerated ester transformation, CHO steroids. Laboratory experiments confirmed field analysis. This study innovatively their mechanisms highlighting concerns regarding health risks.

Язык: Английский

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Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114981 - 114981

Опубликована: Июнь 7, 2023

Lipid metabolism disorders are pivotal in the development of various lipid-related diseases, such as obesity, atherosclerosis, non-alcoholic fatty liver disease, type 2 diabetes, and cancer. Celastrol, a bioactive compound extracted from Chinese herb Tripterygium wilfordii Hook F, has recently demonstrated potent lipid-regulating abilities promising therapeutic effects for diseases. There is substantial evidence indicating that celastrol can ameliorate lipid by regulating profiles related metabolic processes, including synthesis, catabolism, absorption, transport, peroxidation. Even wild-type mice show augmented after treatment with celastrol. This review aims to provide an overview recent advancements properties celastrol, well elucidate its underlying molecular mechanisms. Besides, potential strategies targeted drug delivery combination therapy proposed enhance avoid limitations clinical application.

Язык: Английский

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Circadian-clock-controlled endocrine and cytokine signals regulate multipotential innate lymphoid cell progenitors in the bone marrow

Cell Reports, Год журнала: 2024, Номер 43(5), С. 114200 - 114200

Опубликована: Май 1, 2024

Innate lymphoid cells (ILCs), strategically positioned throughout the body, undergo population declines over time. A solution to counteract this problem is timely mobilization of multipotential progenitors from bone marrow. It remains unknown what triggers marrow ILC (ILCPs). We report that ILCPs are regulated by circadian clock emigrate and generate mature ILCs in periphery. found circadian-clock-defective fail normally ILCs. identified circadian-clock-controlled endocrine cytokine cues that, respectively, regulate retention emigration at distinct times each day. Activation stress-hormone-sensing glucocorticoid receptor upregulates CXCR4 on for their marrow, while interleukin-18 (IL-18) RORα signals upregulate S1PR1 Our findings establish important roles homeostatic efflux (BM) ILCPs.

Язык: Английский

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The Effects of Mesenchymal Stem Cells-Derived Exosomes on Metabolic Reprogramming in Scar Formation and Wound Healing

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 9871 - 9887

Опубликована: Сен. 1, 2024

Pathological scarring results from aberrant cutaneous wound healing due to the overactivation of biological behaviors human skin fibroblasts, characterized by local inordinate inflammation, excessive extracellular matrix and collagen deposition. Yet, its underlying pathogenesis opinions vary, which could be caused increased mechanical tension, enhanced continuous gene mutation, as well cellular metabolic disorder, etc. Metabolic reprogramming is process pattern cells undergoes a systematic adjustment transformation adapt changes external environment meet needs their growth differentiation. Therefore, abnormality in within wounds scars attaches great importance scar formation. Mesenchymal stem cells-derived exosomes (MSC-Exo) are vesicles that play an important role tissue repair, cancer treatment immune regulation. However, there not work detail relevant studies. Herein, we gave comprehensive summary existing research on three main metabolisms, including glycometabolism, lipid metabolism amino acid metabolism, MSC-Exo regulating formation for further reference.

Язык: Английский

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