Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Molecular Neurobiology, Год журнала: 2024, Номер unknown
Опубликована: Июнь 29, 2024
Язык: Английский
Процитировано
1
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(12), С. 5435 - 5450
Опубликована: Авг. 13, 2024
Leber's hereditary optic neuropathy (LHON) is an ocular mitochondrial disease that involves the impairment of complex I, which important contributor to blindness among young adults across globe. However, disorder has no available cures, since approved drug idebenone for LHON in Europe relies on bypassing I defects rather than fixing them. Herein, PARKIN mRNA-loaded nanoparticle (mNP)-engineered mitochondria (mNP-Mito) were designed replace dysfunctional with delivery exogenous mitochondria, normalizing function treating LHON. The mNP-Mito facilitated supplementation healthy containing functional via transfer, along elimination impaired enhanced PARKIN-mediated mitophagy process. In a mouse model induced inhibitor (rotenone, Rot), presence and exhibited sharp increase activity (76.5%) compared group exposed Rot damage (29.5%), greatly promoted restoration ATP generation mitigation disease-related phenotypes. This study highlights significance nanoengineered as promising feasible tool replacement repair therapies.
Язык: Английский
Процитировано
1
Bioactive Materials, Год журнала: 2024, Номер 46, С. 229 - 241
Опубликована: Дек. 20, 2024
Язык: Английский
Процитировано
1
Nanoscale Advances, Год журнала: 2024, Номер 6(14), С. 3590 - 3601
Опубликована: Янв. 1, 2024
(A) Synthetic procedures for OPN-targeted nanoparticles (OPN@PFP-DiR NPs) via two step emulsion method and carbodiimide method. (B) Enhanced dual-modal imaging performed by OPN@PFP-DiR NPs intravenous injection.
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2024, Номер 34(48)
Опубликована: Авг. 21, 2024
Abstract Immunosuppression is ubiquitous in solid tumors, characterized by few cytotoxic T infiltrations, abundant inflammation enrichment, immunosuppressive cell recruitment, etc., which especially potentiated incomplete tumor resection. In this report, multi‐hierarchical Fe single‐atom nanozymes (SAzymes) featuring axially‐coordinated O‐Fe‐N 4 active centers are constructed to reshape tumor‐associated macrophages (TAMs) epigenetics via repolarizing their phenotypes, highly profitable for mitigating immunosuppression after radiofrequency ablation (iRFA). Therein, a nitrogen‐doped bamboo‐like carbon nanotube (N‐BCNT) engineered coordinatively immobilize atoms, wherein another axial coordination (O) introduced further switch non‐polar Fe‐N polar . The polarization switching of synergies with N doping‐encouraged electron transport, low‐temperature synthesis‐discouraged loss and large surface area‐unlocked enrichment confer tetra‐enzymic catalysis activities including peroxidase, oxidase, catalase, glutathione maximumly favoring reactive oxygen species (ROS) production hypoxia reversal. After delivering TAMs polarization‐encouraged drug, toosendanin, altered phenotypes repolarized relieve magnify immune responses, suppress residual progression iRFA. Such comprehensive structure optimization strategy provides versatile route design construct SAzymes‐like drugs multi‐enzymatical activities.
Язык: Английский
Процитировано
0
Biomedical Materials, Год журнала: 2024, Номер 19(6), С. 065015 - 065015
Опубликована: Сен. 23, 2024
Abstract Gene therapy often fails due to enzyme degradation and low transfection efficiency, single gene usually cannot completely kill tumor cells. Several studies have reported that tripartite motif-containing protein 37 (TRIM37) plays a significant role in promoting the occurrence development of triple negative breast cancer (TNBC). Herein, we constructed siTRIM37 IR780 co-loaded nanobubbles (NBs) achieve combination sonodynamic (SDT) against TNBC. On one hand, ultrasound irradiation causes siRNA@IR780 NBs rupture produce targeted NB destruction effect, which promotes entry into cells, increasing local concentration efficiency. other under stimulation ultrasound, generates reactive oxygen species TNBC Mechanism reveal TRIM37 is an anti-apoptotic TNBC, inhibiting expression can induce cell death through apoptotic pathway. And SDT aggravate degree apoptosis increase death. Therefore, NBs-mediated may provide new treatment approach for future.
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2024, Номер 522, С. 216242 - 216242
Опубликована: Сен. 25, 2024
Язык: Английский
Процитировано
0
Small, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 7, 2024
Immunotherapy involving PDL1 degradation holds great potential in anti-tumor treatment. Optimal design of degraders and subsequent efficient delivery into tumors are essential for expected efficacy, especially when abnormal tumor vasculature is considered. Herein, a nanodroplet-based novel drug platform termed as NDs
Язык: Английский
Процитировано
0
Small, Год журнала: 2024, Номер unknown
Опубликована: Дек. 15, 2024
Abstract The treatment of brain diseases has always been the focus attention. Due to presence blood‐brain barrier (BBB), most small molecule drugs are difficult reach brain, leading undesirable therapeutic outcomes. Recently, nanomedicines that can cross BBB and precisely target lesion sites have emerged as thrilling tools enhance early diagnosis treat various intractable disorders. Extensive research shown reactive oxygen species (ROS) play a crucial role in occurrence progression diseases, including tumors neurodegenerative (NDDs) such Alzheimer's disease, Parkinson's stroke, or traumatic injury, making ROS potential target. In this review, on structure function well mechanisms first elaborated through which nanomedicine traverses it. Then, recent studies production summarized photodynamic therapy (PDT), chemodynamic (CDT), sonodynamic (SDT) for treating tumors, depletion NDDs. This provides valuable guidance future design ROS‐targeted disease treatment. ongoing challenges perspectives developing nanomedicine‐based management also discussed outlined.
Язык: Английский
Процитировано
0
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0