Journal of Neuroinflammation,
Год журнала:
2024,
Номер
21(1)
Опубликована: Июнь 19, 2024
Abstract
A
significant
decrease
in
estrogen
levels
puts
menopausal
women
at
high
risk
for
major
depression,
which
remains
difficult
to
cure
despite
its
relatively
clear
etiology.
With
the
discovery
of
abnormally
elevated
inflammation
depressed
women,
immune
imbalance
has
become
a
novel
focus
study
depression.
In
this
paper,
we
examined
characteristics
and
possible
mechanisms
caused
by
decreased
during
menopause
found
that
deficiency
disrupted
homeostasis,
especially
inflammatory
cytokines
through
ERα/ERβ/GPER-associated
NLRP3/NF-κB
signaling
pathways.
We
also
analyzed
destruction
blood-brain
barrier,
dysfunction
neurotransmitters,
blockade
BDNF
synthesis,
attenuation
neuroplasticity
cytokine
activity,
investigated
estrogen-immuno-neuromodulation
disorders
Current
research
suggests
drugs
targeting
molecules
are
promising
restoring
homeostasis
system
may
play
positive
role
intervention
treatment
Frontiers in Integrative Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Фев. 19, 2024
Bioelectronic
Medicine
stands
as
an
emerging
field
that
rapidly
evolves
and
offers
distinctive
clinical
benefits,
alongside
unique
challenges.
It
consists
of
the
modulation
nervous
system
by
precise
delivery
electrical
current
for
treatment
conditions,
such
post-stroke
movement
recovery
or
drug-resistant
disorders.
The
unquestionable
impact
is
underscored
successful
translation
to
humans
in
last
decades,
long
list
preclinical
studies.
Given
emergency
accelerating
progress
new
neuromodulation
treatments
(i.e.,
hypertension,
autoimmune
degenerative
diseases),
collaboration
between
multiple
fields
imperative.
This
work
intends
foster
multidisciplinary
bring
together
different
provide
fundamental
basis
underlying
Medicine.
In
this
review
we
will
go
from
biophysics
cell
membrane,
which
consider
inner
core
neuromodulation,
patient
care.
We
discuss
recently
discovered
mechanism
neurotransmission
switching
how
it
design,
update
on
neuronal
glial
health
disease.
advances
biomedical
technology
have
facilitated
collection
large
amounts
data,
thereby
introducing
challenges
data
analysis.
approaches
high
throughput
analysis,
encompassing
big
networks,
artificial
intelligence,
internet
things.
Emphasis
be
placed
understanding
electrochemical
properties
neural
interfaces,
along
with
integration
biocompatible
reliable
materials
compliance
regulations
translational
applications.
Preclinical
validation
foundational
process,
critical
aspects
animal
Finally,
focus
point-of-care
ultimate
goal
bioelectronic
medicine.
a
call
scientists
common
endeavor:
accelerate
decoding
era
therapeutic
possibilities.
Trends in Neurosciences,
Год журнала:
2024,
Номер
47(4), С. 289 - 302
Опубликована: Март 22, 2024
Selective
vulnerability
of
specific
brain
regions
and
cell
populations
is
a
hallmark
neurodegenerative
disorders.
Mechanisms
selective
involve
neuronal
heterogeneity,
functional
specializations,
differential
sensitivities
to
stressors
pathogenic
factors.
In
this
review
we
discuss
the
growing
body
literature
suggesting
that,
like
neurons,
astrocytes
are
heterogeneous
specialized,
respond
integrate
diverse
inputs,
induce
effects
on
function.
disease,
undergo
specific,
context-dependent
changes
that
promote
different
trajectories
outcomes.
We
propose
contribute
through
maladaptive
transitions
context-divergent
phenotypes
impair
functions.
Further
studies
multifaceted
roles
in
disease
may
provide
new
therapeutic
approaches
enhance
resilience
against
Nutrients,
Год журнала:
2024,
Номер
16(8), С. 1232 - 1232
Опубликована: Апрель 20, 2024
L-carnitine
(LC),
a
vital
nutritional
supplement,
plays
crucial
role
in
myocardial
health
and
exhibits
significant
cardioprotective
effects.
LC,
being
the
principal
constituent
of
clinical-grade
supplements,
finds
extensive
application
recovery
treatment
diverse
cardiovascular
cerebrovascular
disorders.
However,
controversies
persist
regarding
utilization
LC
nervous
system
diseases,
with
varying
effects
observed
across
numerous
mental
neurological
This
article
primarily
aims
to
gather
analyze
database
information
comprehensively
summarize
therapeutic
potential
patients
suffering
from
diseases
while
providing
valuable
references
for
further
research.
Journal of Neuroinflammation,
Год журнала:
2024,
Номер
21(1)
Опубликована: Июнь 19, 2024
Abstract
A
significant
decrease
in
estrogen
levels
puts
menopausal
women
at
high
risk
for
major
depression,
which
remains
difficult
to
cure
despite
its
relatively
clear
etiology.
With
the
discovery
of
abnormally
elevated
inflammation
depressed
women,
immune
imbalance
has
become
a
novel
focus
study
depression.
In
this
paper,
we
examined
characteristics
and
possible
mechanisms
caused
by
decreased
during
menopause
found
that
deficiency
disrupted
homeostasis,
especially
inflammatory
cytokines
through
ERα/ERβ/GPER-associated
NLRP3/NF-κB
signaling
pathways.
We
also
analyzed
destruction
blood-brain
barrier,
dysfunction
neurotransmitters,
blockade
BDNF
synthesis,
attenuation
neuroplasticity
cytokine
activity,
investigated
estrogen-immuno-neuromodulation
disorders
Current
research
suggests
drugs
targeting
molecules
are
promising
restoring
homeostasis
system
may
play
positive
role
intervention
treatment
