Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155157 - 155157
Опубликована: Авг. 25, 2024
Язык: Английский
Gels, Год журнала: 2023, Номер 9(7), С. 523 - 523
Опубликована: Июнь 27, 2023
Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts water and biological fluids control release based on unique physicochemical properties biocompatibility. Current trends in the development hydrogel systems involve drugs response specific triggers such as pH, temperature, or enzymes targeted reduce potential systemic toxicity. In addition, developing injectable formulations that easily used sustain during this extended time is a growing interest. Another emerging trend synthesis nano other functional substances improving loading efficacy. Following these trends, advanced possessing mechanically improved properties, controlled rates, biocompatibility focus field. More complex multi-drug combination therapies will be developed advancements. polymer-based gaining increasing attention personalized medicine tailored patient, example, combinations, target-specific delivery, improvement disease treatment effectiveness, healthcare cost reduction. Overall, application advancing rapidly, towards more efficient effective future.
Язык: Английский
Процитировано
295
Advanced Functional Materials, Год журнала: 2024, Номер 34(21)
Опубликована: Янв. 30, 2024
Abstract Herein, a borophene/zinc oxide (BZ) nanocomposite is synthesized through straightforward one‐step solvothermal process, avoiding the need for any rigorous reducing agent. The BZ nanocomposites are introduced into semi‐interpenetrating polymer networks to form hydrogels via in situ UV triggered free radical gelation during three‐dimensional (3D) microextrusion printing. exhibit mechanical robustness, high compressibility, pH sensitivity, and microporosity. diffusion behavior of hydrogel shows combination swelling molecular chain relaxation based on its water uptake kinetics. Hydrogels tested environments over multiple cycles ensure structural integrity. rheological assessment proves their elasticity. uniaxial properties support toughness zero permanent set resulting elastomeric soft matrix. cyclic compression test up 100 has negligible data deviations calculating moduli (≈24 kPa). non‐toxic found be effective bactericidal materials both Gram‐positive Gram‐negative bacteria. demonstrates pH‐responsive time‐dependent payload release behavior, suggesting potential as matrix drug carrier biomedical research. To best authors knowledge, this first report BZ‐based biomaterial with antibacterial serving an excellent controlled delivery device.
Язык: Английский
Процитировано
59
Advanced Materials, Год журнала: 2024, Номер 36(34)
Опубликована: Июнь 11, 2024
The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.
Язык: Английский
Процитировано
56
Talanta Open, Год журнала: 2023, Номер 8, С. 100243 - 100243
Опубликована: Июль 8, 2023
Hydrogels have a significant impact on the fields of biological study and medical diagnosis. They are becoming more useful in bioanalytical biosensing applications. The intriguing new nanomaterials quantum dots-hydrogel composites gained lot interest because their unmatched biocompatibility tolerable biodegradability, which opens up wide range possible Focusing synthesis techniques, this review describes current developments composites, such as hydrogel gelation dots (QDs) solution, inserting prepared QDs into hydrogels after gelation, generating situ inside preformed gel, cross-linking through QDs. Biomedical applications bioimaging specifically examined, then inherent problems design optimisation, biocompatibility, bimodal applications, well potential future development, discussed.
Язык: Английский
Процитировано
50
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(5), С. 5272 - 5286
Опубликована: Фев. 21, 2024
Superparamagnetic nanoparticle-arrested hydrogel matrices have immense significance in smart soft biomaterials. Herein, we report the synthesis of superparamagnetic nanoparticle-loaded magneto-responsive tough elastomeric hydrogels for dual-responsive drug delivery. In first phase work, carried out room-temperature amine-functionalized iron oxide nanoparticles (IONPs), and second demonstrated that IONPs could act as a toughening agent well viscosity modifier poly(acrylic acid-co-hydroxyethyl methacrylate) copolymer hydrogels. The was tested by Fourier transformed infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), continuous-wave-electron paramagnetic resonance (CW-EPR). Moreover, affect its gelation time elasticity significantly, which also evaluated from rheological behavior. compressive mechanical strength (∼120 kPa), elasticity, recovery to original shape (zero permanent set), water uptake, thixotropic behavior under dynamic stress hybrid supported robustness swelled state. release showed dual parameter dependency (IONPs cross-linker) responsiveness against both pH static magnetic field. delayed network rupturing, delivery nature, noncytotoxic human live cells promote this an ideal alternative remotely controlled vehicle.
Язык: Английский
Процитировано
44
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 12, 2024
Abstract Cephalopods use stretchy skin and dynamic color‐tuning organs for visual communication camouflage. Inspired by these natural mechanisms, a fluorescent biomaterial deformation‐induced illumination optical is proposed. This the first report of 3D printed soft biomaterials infused with carbon dots hydrothermally derived from chitosan benzalkonium chloride. These exhibit comprehensive array properties, including significant uniaxial stretching, near‐instantaneous response to tactile stimuli pH, UV resistance, antibacterial, antioxidant, noncytotoxicity, highlighting their potential as mechano‐optical materials biomedical applications. The hydrogel's durability evaluated cyclic folding, rolling, twisting tests ensure its integrity good signal‐to‐noise ratio. diffusion mechanism determined water imbibition kinetics, network parameters, time‐dependent breathing. Overcoming common limitations short lifespans complex manufacturing processes in existing hybrids, this work demonstrates straightforward method produce durable, energy‐independent, hydrogel. Combined investigations, molecular modeling used understand interactions hydrogel components.
Язык: Английский
Процитировано
16
Gels, Год журнала: 2025, Номер 11(1), С. 30 - 30
Опубликована: Янв. 2, 2025
This review summarizes the fundamental concepts, recent advancements, and emerging trends in field of stimuli-responsive hydrogels. While numerous reviews exist on this topic, continues to evolve dynamically, certain research directions are often overlooked. To address this, we classify hydrogels based their response mechanisms provide an in-depth discussion key properties mechanisms, including swelling kinetics, mechanical properties, biocompatibility/biodegradability. We then explore hydrogel design, synthesis, structural engineering, followed by overview applications that relatively well established from a scientific perspective, biomedical uses (biosensing, drug delivery, wound healing, tissue engineering), environmental (heavy metal phosphate removal environment polluted water), soft robotics actuation. Additionally, highlight unconventional such as local micro-thermometers cell mechanotransduction. concludes with current challenges future prospects field, aiming inspire further innovations advancements bring them closer societal needs.
Язык: Английский
Процитировано
6
Micromachines, Год журнала: 2025, Номер 16(2), С. 174 - 174
Опубликована: Янв. 31, 2025
Magnetic polymeric conduits are developing as revolutionary materials in regenerative medicine, providing exceptional benefits directing tissue healing, improving targeted medication administration, and facilitating remote control via external magnetic fields. The present article offers a thorough examination of current progress the design, construction, functionalization these hybrid systems. integration nanoparticles into matrices confers distinctive features, including regulated alignment, improved cellular motility, medicinal delivery, while preserving structural integrity. Moreover, incorporation multifunctional attributes, such electrical conductivity for cerebral stimulation optical characteristics real-time imaging, expands their range applications. Essential studies indicate that dimensions, morphology, surface chemistry, composition significantly affect biocompatibility, degrading characteristics, overall efficacy. Notwithstanding considerable advancements, issues concerning long-term biodegradability, scalability persist, addition to must uniform regulatory frameworks facilitate clinical translation. Progress additive manufacturing nanotechnology is overcoming obstacles, creation dynamic adaptive conduit structures designed particular biomedical requirements. conduits, by integrating usefulness safety, set transform therapies, presenting new avenue customized medicine advanced healthcare solutions.
Язык: Английский
Процитировано
2
Pharmaceutics, Год журнала: 2023, Номер 15(2), С. 686 - 686
Опубликована: Фев. 17, 2023
Novel nanomaterials are of interest in biology, medicine, and imaging applications. Multimodal fluorescent-magnetic nanoparticles demand special attention because they have the potential to be employed as diagnostic medication-delivery tools, which, turn, might make it easier diagnose treat cancer, well a wide variety other disorders. The most recent advancements development magneto-fluorescent nanocomposites their applications biomedical field primary focus this review. We describe current developments synthetic methodologies methods for fabrication nanocomposites. multimodal biomedicine, including biological imaging, cancer treatment, drug administration, covered article, an overview future possibilities these technologies is provided.
Язык: Английский
Процитировано
37
Materials Today Communications, Год журнала: 2023, Номер 36, С. 106449 - 106449
Опубликована: Июнь 16, 2023
Язык: Английский
Процитировано
32