Journal of Biochemical and Molecular Toxicology,
Год журнала:
2025,
Номер
39(4)
Опубликована: Апрель 1, 2025
ABSTRACT
Enhanced
macrophage
M2
polarization
and
CD8
+
T
cell
dysfunction
contribute
to
the
pathophysiology
of
non‐small
lung
cancer
(NSCLC).
Motor
neuron
pancreatic
homeobox
1
(MNX1)
has
emerged
as
a
potential
tumor‐promoting
player.
Here,
we
clarified
activity
MNX1
in
NSCLC.
PMA‐induced
THP‐1
M0‐like
macrophages
or
cells
were
co‐cultured
with
NSCLC
cells.
Cell
colony
formation,
migration,
proliferation,
apoptosis,
invasiveness
assessed
by
wound
healing,
CCK‐8,
flow
cytometry,
transwell
assays,
respectively.
The
ratio
CD206
was
analyzed
cytometry.
Ki‐67
expression
tested
immunofluorescence.
ChIP
luciferase
assays
used
evaluate
relationship
between
MYCN
MNX1.
highly
expressed
NSCLC,
its
loss‐of‐function
suppressed
growth,
motility,
depletion
also
diminished
apoptosis.
Mechanistically,
increased
at
transcriptional
level.
increase
reversed
impact
on
malignant
behaviors,
polarization,
viability.
vivo
growth
A549
subcutaneous
xenografts.
Additionally,
counteracted
Wnt/β‐catenin
pathway.
Our
findings
elucidate
oncogenic
role
MYCN/MNX1/Wnt/β‐catenin
pathway
driving
diminishing
study
thus
uncovers
novel
mechanism
underlying
development
highlights
targets
for
combating
Current Pharmaceutical Design,
Год журнала:
2024,
Номер
30(31), С. 2445 - 2467
Опубликована: Май 10, 2024
In
recent
years,
the
field
of
nanotechnology
has
brought
about
significant
advancements
that
have
transformed
landscape
disease
diagnosis,
prevention,
and
treatment,
particularly
in
realm
medical
science.
Among
various
approaches
to
nanoparticle
synthesis,
green
synthesis
method
garnered
increasing
attention.
Silver
nanoparticles
(AgNPs)
emerged
as
noteworthy
nanomaterials
within
spectrum
metallic
employed
for
biomedical
applications.
AgNPs
possess
several
key
attributes
make
them
highly
valuable
field.
They
are
biocompatible,
cost-effective,
environmentally
friendly,
rendering
suitable
bioengineering
Notably,
found
a
prominent
role
domain
cancer
diagnosis.
Research
investigations
provided
evidence
AgNPs'
anticancer
activity,
which
involves
mechanisms
such
DNA
damage,
cell
cycle
arrest,
induction
apoptosis,
regulation
specific
cytokine
genes.
The
primarily
reduction
silver
ions
by
reducing
agents.
Interestingly,
natural
products
living
organisms
proven
be
effective
sources
generation
precursor
materials
used
AgNP
synthesis.
This
comprehensive
review
aims
summarize
aspects
AgNPs,
including
their
characterization,
properties,
biogenic
Furthermore,
highlights
potential
applications
these
combating
cancer.
Non-coding RNA Research,
Год журнала:
2024,
Номер
9(4), С. 1222 - 1234
Опубликована: Май 20, 2024
Ferroptosis,
a
form
of
regulated
cell
death,
has
emerged
as
crucial
process
in
diverse
pathophysiological
states,
encompassing
cancer,
neurodegenerative
ailments,
and
ischemia-reperfusion
injury.
The
glutathione
(GSH)-dependent
lipid
peroxidation
pathway,
chiefly
governed
by
peroxidase
4
(GPX4),
assumes
an
essential
part
driving
ferroptosis.
GPX4,
the
principal
orchestrator
ferroptosis,
garnered
significant
attention
across
cardiovascular,
neuroscience
domains
over
past
decade.
Noteworthy
investigations
have
elucidated
indispensable
functions
ferroptosis
numerous
diseases,
including
tumorigenesis,
wherein
robust
within
cells
can
impede
tumor
advancement.
Recent
research
underscored
complex
regulatory
role
non-coding
RNAs
(ncRNAs)
regulating
GSH-GPX4
network,
thus
influencing
cellular
susceptibility
to
This
exhaustive
review
endeavors
probe
into
multifaceted
processes
which
ncRNAs
control
network
Specifically,
we
delve
miRNAs,
lncRNAs,
circRNAs
GPX4
expression
impacting
Moreover,
discuss
clinical
implications
dysregulated
interactions
between
several
conditions,
underscoring
their
capacity
viable
targets
for
therapeutic
intervention.
Additionally,
explores
emerging
strategies
aimed
at
targeting
modulate
pathway
manipulate
advantage.
A
comprehensive
understanding
these
intricate
networks
furnishes
insights
innovative
avenues
diseases
associated
with
perturbed
thereby
laying
groundwork
interventions
ferroptosis-related
pathological
conditions.
Current Genomics,
Год журнала:
2024,
Номер
25(5), С. 343 - 357
Опубликована: Май 23, 2024
The
MALAT1,
a
huge
non-coding
RNA,
recently
came
to
light
as
multifaceted
regulator
in
the
intricate
landscape
of
breast
cancer
(BC)
progression.
This
review
explores
functions
and
molecular
interactions
shedding
on
its
profound
implications
for
understanding
BC
pathogenesis
advancing
therapeutic
strategies.
article
commences
by
acknowledging
global
impact
pressing
need
insights
into
underpinnings.
It
is
stated
that
core
lncRNA
MALAT1
has
range
roles
both
healthy
diseased
cell
functions.
this
unravels
MALAT1's
role
progression,
elucidating
participation
critical
processes
like
resistance,
invasion,
relocation,
proliferating
cells
therapy.
mechanisms
through
which
modulates
gene
expression,
interacts
with
other
molecules,
influences
signalling
pathways.
Furthermore,
paper
emphasizes
clinical
significance
possible
prognostic
diagnostic
biomarker.
Concluding
forward-looking
note,
highlights
broader
biology,
such
connections
therapy
resistance
metastasis.
underscores
deeper
investigations
these
pave
way
precision
medicine
approaches.
pivotal
progression
deciphering
beyond
genome,
offering
disease
potential
targeted
interventions.
