Acta Neurobiologiae Experimentalis,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
MicroRNA‑regulated
gene
expression
plays
an
important
role
in
autoimmune
diseases,
such
as
multiple
sclerosis
(MS).
This
study
investigated
the
patterns
of
microRNAs
(miRNAs)
MS
brain
tissues
using
animal
experimental
encephalomyelitis
(EAE)
model
treated
with
Hypericum
perforatum
(HP)
oil.
C57BL/6
J
mice
were
divided
into
two
groups:
and
control.
The
group
was
subdivided
sham
(MS)
MS+HP.
After
EAE
induction
treatment
protocol,
miRNA
profiles
determined
samples
groups.
array
data
identified
eleven
miRNAs
candidate
validation
performed
by
RT‑qPCR.
A
literature
review
validated
found
that
six
(miR‑200a‑3p,
miR‑200b‑3p,
miR‑200c‑3p,
miR‑182‑5p,
miR‑183‑5p,
miR‑1298‑5p)
directly
associated
MS.
These
have
been
suggested
biomarkers
because
they
are
highly
correlated
pathology
disease.
Furthermore,
analysis
five
(miR‑299a‑5p,
miR‑206‑3p,
miR‑325‑5p,
miR‑10b‑5p,
miR‑429‑3p)
likely
to
be
pathogenesis,
which
could
helpful
diagnosis
research
offers
vital
insights
utilized
creating
advancing
treatments
for
Gene,
Год журнала:
2024,
Номер
933, С. 149011 - 149011
Опубликована: Окт. 18, 2024
Systemic
lupus
erythematosus
(SLE)
is
a
complex
autoimmune
disease
marked
by
abnormal
B-cell
proliferation
and
increased
autoantibodies.
miRNAs
play
crucial
role
in
regulating
dysfunction
SLE
pathology.
influence
DNA
methylation,
activation,
gene
expression,
contributing
to
pathogenesis.
impact
B
cells
through
key
processes
like
proliferation,
differentiation,
tolerance,
apoptosis.
also
exacerbate
inflammation
immune
responses
modulating
Interleukin
4
(IL-4),
IL-6,
interferon
cytokines.
Autophagy,
degradation
mechanism,
regulated
specific
that
This
article
explores
the
of
multiple
development,
survival,
responses,
influencing
miR-23a,
miR-17
∼
92
family,
miR-125b/miR-221
affect
development
transcription
factors,
signaling
pathways,
cell
cycle
genes.
such
as
miR-181a-5p
miR-23a-5p
are
differentially
across
developmental
stages,
emphasizing
their
regulatory
roles
biology.
synthesizes
miRNA-B
interactions
offer
new
strategies
directions
for
diagnosis
treatment.
Acta Neurobiologiae Experimentalis,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
MicroRNA‑regulated
gene
expression
plays
an
important
role
in
autoimmune
diseases,
such
as
multiple
sclerosis
(MS).
This
study
investigated
the
patterns
of
microRNAs
(miRNAs)
MS
brain
tissues
using
animal
experimental
encephalomyelitis
(EAE)
model
treated
with
Hypericum
perforatum
(HP)
oil.
C57BL/6
J
mice
were
divided
into
two
groups:
and
control.
The
group
was
subdivided
sham
(MS)
MS+HP.
After
EAE
induction
treatment
protocol,
miRNA
profiles
determined
samples
groups.
array
data
identified
eleven
miRNAs
candidate
validation
performed
by
RT‑qPCR.
A
literature
review
validated
found
that
six
(miR‑200a‑3p,
miR‑200b‑3p,
miR‑200c‑3p,
miR‑182‑5p,
miR‑183‑5p,
miR‑1298‑5p)
directly
associated
MS.
These
have
been
suggested
biomarkers
because
they
are
highly
correlated
pathology
disease.
Furthermore,
analysis
five
(miR‑299a‑5p,
miR‑206‑3p,
miR‑325‑5p,
miR‑10b‑5p,
miR‑429‑3p)
likely
to
be
pathogenesis,
which
could
helpful
diagnosis
research
offers
vital
insights
utilized
creating
advancing
treatments
for
