Oncology Letters, Год журнала: 2024, Номер 27(5)

Опубликована: Март 22, 2024

Elevated expression of long non-coding RNA homeobox A cluster antisense 2 (lncRNA HOXA-AS2) is known to have prognostic value in various solid tumors. The present meta-analysis aimed comprehensively quantify its significance across a wider spectrum malignancies and provide an updated synthesis evidence that could refine models. To achieve this aim, multiple databases were carefully searched for lncRNA HOXA-AS2-related articles published the past 10 years. Hazard ratios (HRs) or odds (ORs) with 95% confidence intervals (CIs) calculated demonstrate HOXA-AS2 using Stata 15.0 software. function was inferred from associations key clinical outcomes such as lymph node metastasis, distant tumor stage size, which may reflect role biology. In systematic review 454 patients 7 studies, it found high significantly associated shorter overall survival (OS) time cancer (HR=2.14; CI, 1.40-3.27; P<0.001). High also metastasis [odds ratio (OR)=2.06; 1.07-3.99; P=0.032], (OR=2.11; 1.15-3.88; P=0.016), advanced (OR=2.71; 1.50-4.89; P=0.001) larger size (OR=2.02; 0.86-4.78; P=0.006). However, no significant association observed age (OR=1.00; 0.63-1.59; P=0.991) sex (OR=1.55; 0.72-3.34; P=0.258). conclusion, elevated related poor types, osteosarcoma, non-small cell lung papillary thyroid carcinoma, finding further confirmed by study. Specifically, potential lncRNAHOXA-AS2 biomarker assessing stage, risk OS demonstrated. results study indicated not sex, suggesting progression might be independent these factors. This insight direct future research place more focus on relationship between specific types characteristics.

Язык: Английский