The tale of SOX2: Focusing on lncRNA regulation in cancer progression and therapy
Life Sciences,
Год журнала:
2024,
Номер
344, С. 122576 - 122576
Опубликована: Март 14, 2024
Язык: Английский
Unraveling the Molecular Landscape of Osteoarthritis: A Comprehensive Review Focused on the Role of Non-Coding RNAs
Pathology - Research and Practice,
Год журнала:
2024,
Номер
260, С. 155446 - 155446
Опубликована: Июль 3, 2024
Язык: Английский
Targeting Regulatory Noncoding RNAs in Human Cancer: The State of the Art in Clinical Trials
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 471 - 471
Опубликована: Апрель 4, 2025
Noncoding
RNAs
(ncRNAs)
are
a
heterogeneous
group
of
RNA
molecules
whose
classification
is
mainly
based
on
arbitrary
criteria
such
as
the
molecule
length,
secondary
structures,
and
cellular
functions.
A
large
fraction
these
ncRNAs
play
regulatory
role
regarding
messenger
(mRNAs)
or
other
ncRNAs,
creating
an
intracellular
network
cross-interactions
that
allow
fine
complex
regulation
gene
expression.
Altering
balance
between
interactions
may
be
sufficient
to
cause
transition
from
health
disease
vice
versa.
This
leads
possibility
intervening
in
mechanisms
re-establish
patients.
The
associated
with
all
cancer
hallmarks,
proliferation,
apoptosis,
invasion,
metastasis,
genomic
instability.
Based
function
performed
carcinogenesis,
behave
either
oncogenes
tumor
suppressors.
However,
this
distinction
not
rigid;
some
can
fall
into
both
classes
depending
tissue
considered
target
molecule.
Furthermore,
them
also
involved
regulating
response
traditional
cancer-therapeutic
approaches.
In
general,
molecular
by
very
still
largely
unclear,
but
it
has
enormous
potential
for
development
new
therapies,
especially
cases
where
methods
fail,
their
use
novel
more
efficient
biomarkers.
Overall,
review
will
provide
brief
overview
human
biology,
specific
focus
describing
most
recent
ongoing
clinical
trials
(CT)
which
have
been
tested
therapeutic
agents
evaluated
Язык: Английский
Uncovering the Crosstalk between Pseudogenes and Non-Coding RNAs in Tumorigenesis
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 27, 2025
The
expression
of
genes
gets
influenced
by
pseudogenes
through
their
interactions
with
non-coding
RNAs
(ncRNAs)
that
include
microRNAs
(miRNAs)
and
long
(lncRNAs)
PIWI-interacting
(piRNAs).
This
chapter
seeks
to
describe
pseudogene-ncRNA
interactions,
highlight
new
roles
in
cancer
biology,
discuss
potential
clinics.
Pseudogenes
act
as
competing
endogenous
(ceRNAs)
bind
miRNAs
control
the
oncogenes
tumor
suppressors,
thus
affecting
oncogenic
tumor-suppressive
pathways.
Furthermore,
pseudogene-derived
lncRNAs
piRNAs
regulate
transcription
genome
stability,
which
are
crucial
for
progression.
Recent
studies
have
shown
networks
can
be
used
biomarkers
early
detection,
prognosis,
therapeutic
intervention.
However,
quite
different
from
one
type
another.
reviews
current
understanding
a
focus
on
significance
improve
diagnosis
treatment.
Язык: Английский