The tale of SOX2: Focusing on lncRNA regulation in cancer progression and therapy

Life Sciences, Journal Year: 2024, Volume and Issue: 344, P. 122576 - 122576

Published: March 14, 2024

Language: Английский

Targeting Regulatory Noncoding RNAs in Human Cancer: The State of the Art in Clinical Trials

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 471 - 471

Published: April 4, 2025

Noncoding RNAs (ncRNAs) are a heterogeneous group of RNA molecules whose classification is mainly based on arbitrary criteria such as the molecule length, secondary structures, and cellular functions. A large fraction these ncRNAs play regulatory role regarding messenger (mRNAs) or other ncRNAs, creating an intracellular network cross-interactions that allow fine complex regulation gene expression. Altering balance between interactions may be sufficient to cause transition from health disease vice versa. This leads possibility intervening in mechanisms re-establish patients. The associated with all cancer hallmarks, proliferation, apoptosis, invasion, metastasis, genomic instability. Based function performed carcinogenesis, behave either oncogenes tumor suppressors. However, this distinction not rigid; some can fall into both classes depending tissue considered target molecule. Furthermore, them also involved regulating response traditional cancer-therapeutic approaches. In general, molecular by very still largely unclear, but it has enormous potential for development new therapies, especially cases where methods fail, their use novel more efficient biomarkers. Overall, review will provide brief overview human biology, specific focus describing most recent ongoing clinical trials (CT) which have been tested therapeutic agents evaluated

Language: Английский

Unraveling the Molecular Landscape of Osteoarthritis: A Comprehensive Review Focused on the Role of Non-Coding RNAs

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155446 - 155446

Published: July 3, 2024

Language: Английский