Carbohydrate Polymers, Год журнала: 2024, Номер 332, С. 121900 - 121900
Опубликована: Фев. 3, 2024
Язык: Английский
Polymers, Год журнала: 2020, Номер 12(6), С. 1397 - 1397
Опубликована: Июнь 22, 2020
In the past few decades, polymeric nanocarriers have been recognized as promising tools and gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical biomedical applications. Remarkably, these could be further modified stimuli-responsive systems based on mechanism of triggered release, i.e., response a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) effective biodistribution controlled release drugs genes at sites. Various nanoparticles (NPs) functionalized used templates imaging form metallic NPs, dendrimers, quantum dots, liposomes. The use active compounds has attracted considerable interest various cancer therapy fields. So-called smart nanopolymer are built respond certain stimuli such pH, light intensity wavelength, electrical, magnetic ultrasonic Many techniques explored optical imaging, resonance (MRI), nuclear photoacoustic (PAI), single photon emission computed tomography (SPECT), positron (PET). This review reports most recent developments methods by analyzing examples nanopolymers that can imaged using one more techniques. Unique features, nontoxicity, water solubility, biocompatibility, presence multiple functional groups, designate nanocues attractive nanomedicine candidates. this context, we summarize classes multifunctional, polymeric, nano-sized formulations liposomes, micelles, nanogels, dendrimers.
Язык: Английский
Процитировано
393
Advanced Drug Delivery Reviews, Год журнала: 2020, Номер 156, С. 133 - 187
Опубликована: Янв. 1, 2020
Язык: Английский
Процитировано
275
Nanomaterials, Год журнала: 2020, Номер 10(10), С. 1970 - 1970
Опубликована: Окт. 5, 2020
Biodegradable natural polymers have been investigated extensively as the best choice for encapsulation and delivery of drugs. The research has attracted remarkable attention in pharmaceutical industry. shortcomings conventional dosage systems, along with modified targeted drug methods, are addressed by using improved bioavailability, biocompatibility, lower toxicity. Therefore, nanomedicines now considered to be an innovative type medication. This review critically examines use biodegradable their systems local or controlled/sustained release against fatal diseases.
Язык: Английский
Процитировано
269
Chemical Reviews, Год журнала: 2024, Номер 124(9), С. 5505 - 5616
Опубликована: Апрель 16, 2024
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.
Язык: Английский
Процитировано
226
Journal of Cleaner Production, Год журнала: 2021, Номер 315, С. 128221 - 128221
Опубликована: Июль 4, 2021
Язык: Английский
Процитировано
216
International Journal of Biological Macromolecules, Год журнала: 2021, Номер 195, С. 190 - 197
Опубликована: Дек. 9, 2021
Язык: Английский
Процитировано
203
Advanced Materials, Год журнала: 2021, Номер 33(38)
Опубликована: Авг. 4, 2021
Abstract Bacteria are one of the main groups organisms, which dynamically and closely participate in human health disease development. With integration chemical biotechnology, bacteria have been utilized as an emerging delivery system for various biomedical applications. Given unique features such their intrinsic biocompatibility motility, bacteria‐based systems drawn wide interest diagnosis treatment diseases, including cancer, infectious kidney failure, hyperammonemia. Notably, at interface biotechnology bacteria, many research opportunities initiated, opening a promising frontier application. Herein, current synergy design principles systems, microbial modulation, clinical translation reviewed, with special focus on advances therapy.
Язык: Английский
Процитировано
175
Molecules, Год журнала: 2020, Номер 25(12), С. 2866 - 2866
Опубликована: Июнь 22, 2020
The field of gene therapy has experienced an insurgence attention for its widespread ability to regulate expression by targeting genomic DNA, messenger RNA, microRNA, and short-interfering RNA treating malignant non-malignant disorders. Numerous nucleic acid analogs have been developed target coding or non-coding sequences the human genome regulation. However, broader clinical applications limited due their poor cell organ-specific delivery. To resolve these issues, non-viral vectors based on nanoparticles, liposomes, polyplexes date. This review is centered mainly comprising cationic lipids polymers acid-based delivery numerous therapy-based applications.
Язык: Английский
Процитировано
167
Journal of Hazardous Materials, Год журнала: 2020, Номер 402, С. 123359 - 123359
Опубликована: Июль 2, 2020
Язык: Английский
Процитировано
142
Chemical Engineering Journal, Год журнала: 2023, Номер 460, С. 141852 - 141852
Опубликована: Фев. 11, 2023
Язык: Английский
Процитировано
118