Journal of Drug Delivery Science and Technology, Год журнала: 2021, Номер 70, С. 102987 - 102987
Опубликована: Ноя. 19, 2021
Язык: Английский
Polymers, Год журнала: 2021, Номер 13(6), С. 904 - 904
Опубликована: Март 15, 2021
Chitosan is a naturally originating product that can be applied in many areas due to its biocompatibility, biodegradability, and nontoxic properties. The broad-spectrum antimicrobial activity of chitosan offers great commercial potential for this product. Nevertheless, the varies, because associated with physicochemical characteristics depends on type microorganism. In review article, fundamental properties, modes action, effects-related factors are discussed. We further summarize how microorganisms genetically respond chitosan. Finally, applications chitosan-based biomaterials, such as nanoparticles films, combination current clinical antibiotics or antifungal drugs, also addressed.
Язык: Английский
Процитировано
566
Heliyon, Год журнала: 2021, Номер 8(1), С. e08674 - e08674
Опубликована: Дек. 24, 2021
Recently, multifunctional drug delivery systems (DDSs) have been designed to provide a comprehensive approach with multiple functionalities, including diagnostic imaging, targeted delivery, and controlled release. Chitosan-based nanoparticles (CSNPs) are employed as imaging delivering the particular sites in regulated manner. Drug release is an important factor ensuring high reproducibility, stability, quality control of CSNPs, scientific-based for developing CSNPs. Several factors influence from composition, composition ratio, ingredient interactions, preparation methods. Early, CSNPs were used improving solubility, pharmacokinetics, pharmacotherapeutics properties. Chitosan has developed toward system by exploring positively charged properties modifiable functional groups. Various modifications polymer backbone, charge, or groups will undoubtedly affect The significant on its therapeutic actions. Our review's objective was summarize discuss relationship between modification kinetics model. Kinetic models help describe rate, leading increased efficiency, accuracy, safety dose, optimizing device's design, evaluating improvement patient compatibility. In conclusion, almost all showed bi-phasic release, initial burst time followed manner achieving expected stimuli external can be applied. promising technique systems.
Язык: Английский
Процитировано
322
Molecules, Год журнала: 2023, Номер 28(18), С. 6624 - 6624
Опубликована: Сен. 14, 2023
Knowing the beneficial aspects of nanomedicine, scientists are trying to harness applications nanotechnology in diagnosis, treatment, and prevention diseases. There also potential uses designing medical tools processes for new generation scientists. The main objective conducting this research review is gather widespread nanomedicine under one heading highlight standard practices field. Comprehensive has been conducted incorporate latest data related medicine therapeutics derived from acknowledged scientific platforms. Nanotechnology used conduct sensitive procedures. showing successful fields diagnostics, disease regenerative medicine, gene therapy, dentistry, oncology, aesthetics industry, drug delivery, therapeutics. A thorough association cooperation between physicians, clinicians, researchers, technologies will bring forward a future where there more calculated, outlined, technically programed field nanomedicine. Advances being made overcome challenges associated with application due pathophysiological basis This highlights multipronged how proving health industry. need minimize health, environmental, ethical concerns linked nanotechnology.
Язык: Английский
Процитировано
232
Advanced Science, Год журнала: 2022, Номер 9(10)
Опубликована: Фев. 3, 2022
Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not only to but also subcellular organelles. Variety natural sources, availability different synthetic routes, versatile molecular architectures, exploitable physicochemical properties, biocompatibility, biodegradability presented polymers one the most desired materials for nanocarrier design. Recent innovative concepts advances PNC-associated nanotechnology providing unprecedented opportunities engineer their functions. The efficiency therapeutic loading has got considerably increased. Structural design-based varieties PNCs widely employed delivery small molecules genes, proteins. gained ever-increasing attention certainly paves way develop advanced nanomedicines. This article presents a comprehensive investigation structural influences properties on drug profiles with perspectives highlighting inevitability incorporating both multi-stimuli-responsive multi-drug single carrier design intelligent new emerging research directions this rapidly developing area.
Язык: Английский
Процитировано
171
3 Biotech, Год журнала: 2021, Номер 11(5)
Опубликована: Апрель 16, 2021
Язык: Английский
Процитировано
161
Materials, Год журнала: 2022, Номер 15(19), С. 6521 - 6521
Опубликована: Сен. 20, 2022
Chitosan is a biodegradable and biocompatible natural polymer that has been extensively explored in recent decades. The Food Drug Administration approved chitosan for wound treatment nutritional use. Furthermore, paved the way advancements different biomedical applications including as nanocarrier tissue-engineering scaffold. Its antibacterial, antioxidant, haemostatic properties make it an excellent option dressings. Because of its hydrophilic nature, ideal starting material hydrogels. To suit specific application demands, can be combined with fillers, such hydroxyapatite, to modify mechanical characteristics pH-sensitive cationic have made popular choice gene delivery cancer therapy. Thus, use nanoparticles developing novel drug systems received special attention. This review aims provide overview chitosan-based nanoparticles, focusing on their versatile sciences engineering.
Язык: Английский
Процитировано
122
Nanomaterials, Год журнала: 2022, Номер 12(2), С. 186 - 186
Опубликована: Янв. 6, 2022
Chitosan and alginate are two of the most studied natural polymers that have attracted interest for multiple uses in their nano form. The biomedical field is one domains benefiting from development nanotechnology, as increasing research has been oriented to developing chitosan-alginate biocompatible delivery vehicles, antimicrobial agents, vaccine adjuvants. Moreover, these nanomaterials origin also become appealing environmental protection (e.g., water treatment, environmental-friendly fertilizers, herbicides, pesticides) food industry. In this respect, present paper aims discuss some newest applications chitosan-alginate-based serve an inception point further field.
Язык: Английский
Процитировано
118
The Science of The Total Environment, Год журнала: 2024, Номер 926, С. 171862 - 171862
Опубликована: Март 23, 2024
Язык: Английский
Процитировано
76
Scientific Reports, Год журнала: 2023, Номер 13(1)
Опубликована: Июнь 9, 2023
Hydrolysis and aminolysis are two main commonly used chemical methods for surface modification of hydrophobic tissue engineering scaffolds. The type reagents along with the concentration treatment time factors that determine effects these on biomaterials. In present study, electrospun poly (ℇ-caprolactone) (PCL) nanofibers were modified through hydrolysis aminolysis. applied solutions NaOH (0.5-2 M) hexamethylenediamine/isopropanol (HMD/IPA, 0.5-2 correspondingly. Three distinct incubation points predetermined treatments. According to scanning electron microscopy results, morphological changes emerged only in higher concentrations solution (1 M 2 prolonged duration (6 12 h). contrast, treatments induced slight features PCL nanofibers. Even though hydrophilicity was noticeably improved both methods, resultant influence comparatively more considerable. As a general trend, resulted moderate decline mechanical performance samples. Energy dispersive spectroscopy analysis indicated elemental after However, X-ray diffraction, thermogravimetric analysis, infrared results did not show noticeable alterations subsequent fibroblast cells well spread exhibited spindle-like shape treated groups. Furthermore, according 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, procedures ameliorated proliferative properties These findings represented nanofibrous samples by can be considered as potentially favorable candidates applications.
Язык: Английский
Процитировано
63
RSC Pharmaceutics, Год журнала: 2024, Номер 1(3), С. 388 - 402
Опубликована: Янв. 1, 2024
Antimicrobial resistance poses a serious threat to global health, necessitating the exploration of innovative solutions.
Язык: Английский
Процитировано
63