Highly efficient bacteria-infected diabetic wound healing employing a melanin-reinforced biopolymer hydrogel

Chemical Engineering Journal, Год журнала: 2023, Номер 460, С. 141852 - 141852

Опубликована: Фев. 11, 2023

Язык: Английский

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ε‑Polylysine-stabilized agarose/polydopamine hydrogel dressings with robust photothermal property for wound healing

Carbohydrate Polymers, Год журнала: 2021, Номер 264, С. 118046 - 118046

Опубликована: Апрель 7, 2021

Язык: Английский

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Natural and Synthetic Polymers for Biomedical and Environmental Applications

Polymers, Год журнала: 2024, Номер 16(8), С. 1159 - 1159

Опубликована: Апрель 20, 2024

Natural and synthetic polymers are a versatile platform for developing biomaterials in the biomedical environmental fields. organic compounds that found nature. The most common natural include polysaccharides, such as alginate, hyaluronic acid, starch, proteins, e.g., collagen, silk, fibrin, bacterial polyesters. have already been applied numerous sectors, carriers drug delivery, tissue engineering, stem cell morphogenesis, wound healing, regenerative medicine, food packaging, etc. Various polymers, including poly(lactic acid), poly(acrylic poly(vinyl alcohol), polyethylene glycol, etc., biocompatible biodegradable; therefore, they studied controlled release systems, nano-carriers, dispersion of biofilms, gene delivery bio-ink 3D-printing, textiles agriculture, heavy metals removal, packaging. In following review, recent advancements polymer chemistry, which enable imparting specific functions will be discussed detail, antiviral, anticancer, antimicrobial activities. This work contains authors’ experimental contributions to applications. review is vast overview used fields, synthesis, isolation methods, critically assessessing their advantages, limitations, prospects.

Язык: Английский

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Ultra‐Thin Flexible Encapsulating Materials for Soft Bio‐Integrated Electronics

Advanced Science, Год журнала: 2022, Номер 9(30)

Опубликована: Авг. 28, 2022

Abstract Recently, bioelectronic devices extensively researched and developed through the convergence of flexible biocompatible materials electronics design that enables more precise diagnostics therapeutics in human health care opens up potential to expand into various fields, such as clinical medicine biomedical research. To establish an accurate stable bidirectional bio‐interface, protection against external environment high mechanical deformation is essential for wearable devices. In case implantable bioelectronics, special encapsulation optimized designs configurations provide electronic stability functionality are required accommodating organ properties, lifespans, functions biofluid environment. Here, this study introduces recent developments ultra‐thin encapsulations with novel can preserve or even improve electrical performance bio‐integrated by supporting safety from destruction contamination well optimizing use systems physiological environments. addition, a summary materials, methods, characteristics most widely used technologies introduced, thereby providing strategic selection appropriate choices recently bioelectronics.

Язык: Английский

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Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications

Pharmaceutics, Год журнала: 2022, Номер 14(5), С. 1097 - 1097

Опубликована: Май 20, 2022

Microneedle (MNs) technology is a recent advancement in biomedical science across the globe. The current limitations of drug delivery, like poor absorption, low bioavailability, inadequate skin permeation, and biodistribution, can be overcome by MN-based delivery. Nanotechnology made significant changes fabrication techniques for microneedles design shifted from conventional to novel, using various types natural synthetic materials their combinations. Nowadays, MNs has gained popularity worldwide research delivery due its multifaceted broad-spectrum applications. This review broadly discusses MN's types, methods, composition, characterization, applications, advancements, global intellectual scenarios.

Язык: Английский

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Polysaccharides based biopolymers for biomedical applications: A review

Polymers for Advanced Technologies, Год журнала: 2023, Номер 35(1)

Опубликована: Окт. 9, 2023

Abstract Polysaccharides are a class of natural biopolymers that have attracted significant attention due to their unique properties, which make them attractive for use in wide range applications. These an important role our daily life, and designing biomaterials biomedical applications requires careful consideration factors such as biocompatibility, biodegradability, renewability, affordability, availability, all can be achieved with polysaccharides. This review paper focuses on the polysaccharides provides in‐depth analysis potential arabinoxylan, type hemicellulose, various fields, including drug delivery, infection control, tissue engineering, wound healing, others. Arabinoxylan, is derived from plants, most abundant hemicellulose has diverse catalyst its renewable nature. Polysaccharide‐based covers, delivery systems, food preservation, biocomposite films, making emerging excipient pharmaceutical research. highlights polysaccharide‐based science suggests continued research development will lead broader more innovative field. The significantly advance healthcare improve patient outcomes.

Язык: Английский

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Simulation-based approaches for drug delivery systems: Navigating advancements, opportunities, and challenges

Journal of Molecular Liquids, Год журнала: 2023, Номер 395, С. 123888 - 123888

Опубликована: Дек. 27, 2023

Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals' targeted and effective administration. However, the intricate interplay between formulations poses challenges their design optimization. Simulations have emerged as indispensable tools for comprehending these interactions enhancing DDS performance to address this complexity. This comprehensive review explores latest advancements simulation techniques provides detailed analysis. The encompasses various methodologies, including molecular dynamics (MD), Monte Carlo (MC), finite element analysis (FEA), computational fluid (CFD), density functional theory (DFT), machine learning (ML), dissipative particle (DPD). These are critically examined context of research. article presents illustrative case studies involving liposomal, polymer-based, nano-particulate, implantable DDSs, demonstrating influential simulations optimizing systems. Furthermore, addresses advantages limitations It also identifies future directions research development, such integrating multiple techniques, refining validating models greater accuracy, overcoming limitations, exploring applications personalized medicine innovative DDSs. employing like MD, MC, FEA, CFD, DFT, ML, DPD offer crucial insights into behaviour, aiding Despite advantages, rapid cost-effective screening, require validation addressing limitations. Future should focus on models, enhance outcomes. paper underscores contribution emphasizing providing valuable facilitating development optimization ultimately patient As we continue explore impact advancing discovery improving DDSs is expected be profound.

Язык: Английский

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A Comprehensive Review of Polysaccharide-Based Hydrogels as Promising Biomaterials

Polymers, Год журнала: 2023, Номер 15(13), С. 2908 - 2908

Опубликована: Июнь 30, 2023

Polysaccharides have emerged as a promising material for hydrogel preparation due to their biocompatibility, biodegradability, and low cost. This review focuses on polysaccharide-based hydrogels’ synthesis, characterization, applications. The various synthetic methods used prepare hydrogels are discussed. characterization techniques also highlighted evaluate the physical chemical properties of hydrogels. Finally, applications SAPs in fields discussed, along with potential benefits limitations. Due environmental concerns, this shows growing interest developing bio-sourced made from natural materials such polysaccharides. many beneficial properties, including good mechanical morphological thermal stability, non-toxicity, abundance, economic viability, swelling ability. However, some challenges remain be overcome, limiting formulation complexity establishing general protocol calculating water absorption retention capacity. Furthermore, development requires multidisciplinary approach research should focus improving modification, well exploring Biocompatibility, biodegradation, regulatory approval pathway carefully evaluated ensure safety efficacy.

Язык: Английский

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Recent advances in cellulose, pectin, carrageenan and alginate-based oral drug delivery systems

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 244, С. 125357 - 125357

Опубликована: Июнь 15, 2023

Язык: Английский

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Injectable and self-healable nano-architectured hydrogel for NIR-light responsive chemo- and photothermal bacterial eradication

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(7), С. 1905 - 1925

Опубликована: Янв. 1, 2024

A stimuli-responsive, injectable, and in situ -forming hydrogel with synergistic, self-healing, on-demand drug-delivery antibacterial properties.

Язык: Английский

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