Gels,
Год журнала:
2025,
Номер
11(2), С. 131 - 131
Опубликована: Фев. 12, 2025
Local
anesthetics
(LAs)
have
been
indispensable
in
clinical
pain
management,
yet
their
limitations,
such
as
short
duration
of
action
and
systemic
toxicity,
necessitate
improved
delivery
strategies.
Hydrogels,
with
biocompatibility,
tunable
properties,
ability
to
modulate
drug
release,
extensively
explored
platforms
for
enhancing
LA
efficacy
safety.
This
narrative
review
explores
the
historical
development
LAs,
physicochemical
applications,
providing
a
foundation
understanding
integration
hydrogels
anesthetic
delivery.
Advances
thermoresponsive,
stimuli-responsive,
multifunctional
demonstrated
significant
potential
prolonging
analgesia
reducing
exposure
preclinical
studies,
while
early
findings
highlight
feasibility
thermoresponsive
hydrogel
formulations.
Despite
these
advancements,
challenges
burst
mechanical
instability,
regulatory
considerations
remain
critical
barriers
translation.
Emerging
innovations,
including
nanocomposite
hydrogels,
biofunctionalized
matrices,
smart
materials,
offer
solutions
limitations.
Future
research
should
focus
on
optimizing
formulations,
expanding
validation,
integrating
advanced
fabrication
technologies
3D
printing
artificial
intelligence-driven
design
enhance
personalized
management.
By
bridging
materials
science
pharmacology,
this
provides
comprehensive
perspective
current
trends
future
directions
hydrogel-based
systems.
Giant,
Год журнала:
2024,
Номер
19, С. 100301 - 100301
Опубликована: Июнь 6, 2024
The
global
community
has
encountered
numerous
challenges
concerning
environmental
sustainability,
encompassing
issues
like
waste
generation,
depletion
of
natural
resources,
air
pollution,
and
other
threats
to
human
well-being.
Consequently,
the
pursuit
an
eco-friendly
environment
emerged
as
a
critical
concern
in
recent
years.
Polysaccharides,
being
biopolymers,
have
garnered
significant
attention
owing
their
distinctive
properties
that
make
them
versatile
for
various
applications.
Numerous
sustainable
environmentally
friendly
polysaccharides,
such
chitosan,
cellulose,
starch,
hyaluronic
acid,
alginate,
inulin,
been
identified.
This
article
highlights
characteristics
renewable
categorization,
potential
contribute
sustainability.
It
introduces
extraction
methods
aimed
at
minimizing
chemical
pollution.
Through
careful
selection
diverse
polysaccharides
application
functionalization
techniques,
suggests
possibility
obtaining
suitable
superabsorbent
hydrogels,
appropriate
nanocomposites,
effective
scaffolds.
significance
utilizing
polysaccharide-based
materials
is
explored
detail,
emphasizing
exceptional
properties.
Additionally,
discusses
applications
polymers,
including
agriculture,
biomedicine,
food
packaging.
Porous
aromatic
frameworks
(PAFs)
are
a
fundamental
group
of
porous
materials
characterized
by
their
distinct
structural
features
and
large
surface
areas.
These
synthesized
from
building
units
linked
strong
carbon–carbon
bonds,
which
confer
exceptional
rigidity
long-term
stability.
PAFs
functionalities
may
arise
directly
the
intrinsic
chemistry
or
through
postmodification
motifs
using
well-defined
chemical
processes.
Compared
to
other
traditional
such
as
zeolites
metallic-organic
frameworks,
demonstrate
superior
stability
under
severe
treatments
due
robust
bonding.
Even
in
challenging
environments,
ease
functionalization
flexibility
specificity.
Research
on
has
significantly
expanded
accelerated
over
past
decade,
necessitating
comprehensive
overview
key
advancements
this
field.
This
review
provides
an
in-depth
analysis
recent
advances
synthesis,
functionalization,
dimensionality
PAFs,
along
with
distinctive
properties
wide-ranging
applications.
explores
innovative
methodologies
strategies
for
functionalizing
structures,
manipulation
tailor
specific
potential
Similarly,
application
areas,
including
batteries,
absorption,
sensors,
CO2
capture,
photo-/electrocatalytic
usages,
supercapacitors,
separation,
biomedical
discussed
detail,
highlighting
versatility
addressing
modern
scientific
industrial
challenges.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Cancer
immunotherapy,
which
leverages
immune
system
components
to
treat
malignancies,
has
emerged
as
a
cornerstone
of
contemporary
therapeutic
strategies.
Yet,
critical
concerns
about
the
efficacy
and
safety
cancer
immunotherapies
remain
formidable.
Nanotechnology,
especially
polymeric
nanoparticles
(PNPs),
offers
unparalleled
flexibility
in
manipulation‐from
chemical
composition
physical
properties
precision
control
nanoassemblies.
PNPs
provide
an
optimal
platform
amplify
potency
minimize
systematic
toxicity
broad
spectrum
immunotherapeutic
modalities.
In
this
comprehensive
review,
basics
polymer
chemistry,
state‐of‐the‐art
designs
from
physicochemical
standpoint
for
encompassing
vaccines,
situ
vaccination,
adoptive
T‐cell
therapies,
tumor‐infiltrating
cell‐targeted
antibodies,
cytokine
therapies
are
delineated.
Each
immunotherapy
necessitates
distinctively
tailored
design
strategies
nanoplatforms.
The
extensive
applications
PNPs,
investigation
their
mechanisms
action
enhanced
particularly
focused
on.
profiles
clinical
research
progress
discussed.
Additionally,
forthcoming
developments
emergent
trends
nano‐immunotherapeutics
poised
transform
treatment
paradigms
into
clinics
explored.
Biosensors,
which
combine
physical
transducers
with
biorecognition
elements,
have
seen
significant
advancement
due
to
the
heightened
interest
in
rapid
diagnostic
technologies
across
a
number
of
fields,
including
medical
diagnostics,
environmental
monitoring,
and
food
safety.
In
particular,
polydiacetylene
(PDA)
is
gaining
attention
as
an
ideal
material
for
label-free
colorimetric
biosensor
development
its
unique
color-changing
properties
response
external
stimuli.
PDA
forms
through
self-assembly
diacetylene
monomers,
color
change
occurring
conjugated
backbone
twists
stimuli
such
temperature,
pH,
chemical
interactions.
This
enables
detection
biomarkers,
metal
ions,
toxic
compounds.
Moreover,
combination
polymeric
structures
hydrogels
further
enhances
sensitivity
structural
stability
PDA-based
biosensors,
making
them
reliable
effective
complex
biological
conditions.
review
comprehensively
examines
recent
research
trends
applications
PDA–polymeric
structure
hybrid
while
discussing
future
directions
potential
advancements
this
field.
Processes,
Год журнала:
2025,
Номер
13(2), С. 542 - 542
Опубликована: Фев. 14, 2025
Currently,
approximately
one
third
of
food
is
wasted;
to
counteract
this,
several
novel
packaging
technologies
have
been
developed
extend
its
shelf
life,
among
which
active
stands
out.
In
this
research,
filmogenic
solutions
pectin
and
beeswax
with
the
addition
bioactive
compounds
as
anthocyanins
were
characterized
evaluate
their
potential
application
coatings.
The
antioxidant
antifungal
activity
coatings
determined,
rheological
properties,
pH,
color,
SEM
FT-IR
evaluated.
had
IC50
values
79.52
56.14
μg/mL
for
DPPH•
ABTS•+,
respectively,
0.25%
(w/v)
against
Colletotrichum
siamense,
was
inhibited
by
32.16%
morphological
affectations
in
fungus.
best
formulation
coating
obtained
3%
pectin,
1%
wax,
Tween
80,
0.1,
0.25,
0.5%
added.
properties
showed
adequate
viscosity
(0.08–0.12
Pa·s),
pH
acidic
(3.05–3.78)
reddish
tones.
analysis
that
interactions
between
components
included
C=O
stretching
band
being
shifted
due
intermolecular
micrographs
film
presented
continuous
areas
embedded
wax
crystals.
Promising
results
formulations
suitable
characteristics
use
food.
Journal of Composites Science,
Год журнала:
2024,
Номер
8(8), С. 324 - 324
Опубликована: Авг. 16, 2024
Shape-memory
polymers
(SMPs)
possess
unique
properties
that
respond
to
external
stimuli.
The
current
review
discusses
types
of
SMPs,
fabrication
methods,
and
the
characterization
their
mechanical,
thermal,
shape
recovery
properties.
Research
suggests
SMP
composites,
when
infused
with
fillers,
demonstrate
enhanced
mechanical
thermal
characteristics.
On
other
hand,
blends,
particularly
incorporating
polylactic
acid
(PLA),
exhibit
most
efficient
recovery.
Furthermore,
crosslinking
density
in
polymer
blends
impacts
force,
showcasing
a
correlation
between
energy
storage
capacity
force
networks.
Overall,
show
promising
features,
rendering
them
advantageous
for
applications
artificial
muscles,
soft
actuators,
biomedical
devices.
This
also
future
prospectives
robust
applications.
Gels,
Год журнала:
2024,
Номер
10(10), С. 636 - 636
Опубликована: Сен. 30, 2024
The
innovative
fusion
of
essential
oils
with
hydrogel
engineering
offers
an
optimistic
perspective
for
the
design
and
development
next-generation
materials
incorporating
natural
bioactive
compounds.
This
review
provides
a
comprehensive
overview
latest
advances
in
use
hydrogels
containing
biomedical,
dental,
cosmetic,
food,
food
packaging,
restoration
cultural
heritage
applications.
Polymeric
sources,
methods
obtaining,
cross-linking
techniques,
functional
properties
are
discussed.
unique
characteristics
polymer
agents
highlighted.
These
include
biocompatibility,
nontoxicity,
effective
antibacterial
activity,
control
sustained
prolonged
release
active
substances,
optimal
porosity,
outstanding
cytocompatibility.
Additionally,
specific
distinctive
explored,
along
their
extraction
encapsulation
methods.
advantages
disadvantages
these
also
We
have
considered
limitations
due
to
volatility,
solubility,
environmental
factors,
stability.
importance
loading
hydrogels,
stability,
biological
activity
is
analyzed.
highlights
through
in-depth
analysis,
recent
innovations,
challenges,
future
prospects
encapsulated
potential
multiple
applications
including
biomedicine,
dentistry,
cosmetics,
conservation.
ACS Omega,
Год журнала:
2024,
Номер
9(47), С. 46698 - 46732
Опубликована: Ноя. 14, 2024
Immobilization
of
lipases
by
physical
adsorption
improves
their
stability,
recovery,
and
reusability
in
biotechnological
processes.
The
present
review
provides
an
advanced
bibliometric
analysis
a
comprehensive
overview
research
progress
this
field.
By
searching
Web
Science,
39,575
publications
were
analyzed,
325
relevant
articles
selected.
Key
journals,
countries,
institutions,
authors
identified.
most
cited
focus
on
biofuel
production
industrial
applications.
revealed
four
themes
with
the
biofuel.
method
is
effective
when
appropriate
support
used.
Despite
decrease
patent
applications,
interest
remains
high.
Future
studies
should
optimizing
materials
exploring
new
applications
technique.
detailed
understanding
immobilization
adsorption.
