Redox Biology,
Год журнала:
2017,
Номер
14, С. 47 - 58
Опубликована: Авг. 10, 2017
Association
of
oxidative
stress
with
carcinogenesis
is
well
known,
but
not
understood
well,
as
pathophysiology
generated
during
different
types
anti-cancer
treatments.
Moreover,
recent
findings
indicate
that
cancer
associated
lipid
peroxidation
might
eventually
help
defending
adjacent
nonmalignant
cells
from
invasion.
Therefore,
untargeted
metabolomics
studies
designed
for
advanced
translational
and
clinical
are
needed
to
understand
the
existing
paradoxes
in
oncology,
including
those
related
controversial
usage
antioxidants
aiming
prevent
or
treat
cancer.
In
this
short
review
we
have
tried
put
emphasis
on
importance
development
relation
metabolic
adaptation
particular
allowing
us
conclude
one
main
driving
forces
pathophysiology.
With
many
novel
being
achieved
thus
encouraging
further
scientific
breakthroughs.
Combined
targeted
qualitative
quantitative
methods,
especially
immunochemistry,
research
reveal
bio-signatures
individual
patients
respective
malignant
diseases,
leading
individualized
treatment
approach,
according
concepts
modern
integrative
medicine.
Frontiers in Physiology,
Год журнала:
2020,
Номер
11
Опубликована: Июль 2, 2020
Oxidative
stress
plays
an
essential
role
in
the
pathogenesis
of
chronic
diseases
such
as
cardiovascular
diseases,
diabetes,
neurodegenerative
and
cancer.
Long
term
exposure
to
increased
levels
pro-oxidant
factors
can
cause
structural
defects
at
a
mitochondrial
DNA
level,
well
functional
alteration
several
enzymes
cellular
structures
leading
aberrations
gene
expression.
The
modern
lifestyle
associated
with
processed
food,
wide
range
chemicals
lack
exercise
important
oxidative
induction.
However,
use
medicinal
plants
antioxidant
properties
has
been
exploited
for
their
ability
treat
or
prevent
human
pathologies
which
seems
be
one
causes.
In
this
review
we
discuss
is
triggers
plant-derived
compounds
mechanisms
defenses
that
help
prevention
these
diseases.
Finally,
both
beneficial
detrimental
effects
molecules
are
used
reduce
conditions
discussed.
Antioxidants,
Год журнала:
2020,
Номер
9(9), С. 852 - 852
Опубликована: Сен. 10, 2020
Oxidative
stress
is
defined
as
“an
imbalance
between
oxidants
and
antioxidants
in
favor
of
the
oxidants,
leading
to
a
disruption
redox
signaling
control
and/or
molecular
damage”.
This
Commentary
presents
basic
features
this
global
concept
which
has
attracted
interest
biology
medicine.
The
term
“antioxidants”
cellular
defense
against
predominantly
includes
antioxidant
enzymes
with
their
substrates
coenzymes.
Exogenous
low-molecular-mass
compounds
also
have
role,
but
more
limited.
Multiple
biomarkers
damage
due
oxidative
been
identified
for
different
classes
(protein,
lipid,
carbohydrate,
DNA),
current
state
practical
aspects
health
disease
delineated.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2017,
Номер
2017(1)
Опубликована: Янв. 1, 2017
The
production
of
reactive
species
is
a
core
the
redox
cycling
profile
anthracyclines.
However,
these
molecular
characteristics
can
be
viewed
as
double‐edged
sword
acting
not
only
on
neoplastic
cells
but
also
multiple
cellular
targets
throughout
body.
This
phenomenon
translates
into
anthracycline
cardiotoxicity
that
serious
problem
in
growing
population
paediatric
and
adult
cancer
survivors.
Therefore,
better
understanding
processes
operate
within
go
beyond
cardiomyocytes
necessary
step
to
develop
more
effective
tools
for
prevention
treatment
progressive
often
severe
cardiomyopathy
experienced
by
otherwise
successfully
treated
oncologic
patients.
In
this
review,
we
focus
oxidative
stress‐triggered
events
such
DNA
damage,
senescence,
cell
death
implicated
cardiovascular
toxicity.
involvement
progenitor
cardiac
extracardiac
origin
well
different
types
discussed,
pointing
signals
impact
longevity
functional
competence.
Cells,
Год журнала:
2019,
Номер
8(8), С. 793 - 793
Опубликована: Июль 30, 2019
The
importance
of
reactive
oxygen
species
(ROS)
has
been
gradually
acknowledged
over
the
last
four
decades.
Initially
perceived
as
unwanted
products
detrimental
oxidative
stress,
they
have
upgraded
since,
and
now
ROS
are
also
known
to
be
essential
for
regulation
physiological
cellular
functions
through
redox
signaling.
In
majority
cases,
metabolic
demands,
along
with
other
stimuli,
vital
formation
their
actions.
this
review,
we
focus
on
role
in
regulating
cell
functioning
communication
among
themselves.
relevance
therapy
concepts
is
addressed
here.
In Vivo,
Год журнала:
2019,
Номер
33(4), С. 1011 - 1026
Опубликована: Янв. 1, 2019
Plasma
medicine
comprises
the
application
of
physical
plasma
directly
on
or
in
human
body
for
therapeutic
purposes.
Three
most
important
basic
effects
are
relevant
medical
applications:
i)
inactivation
a
broad
spectrum
microorganisms,
including
multidrug-resistant
pathogens,
ii)
stimulation
cell
proliferation
and
angiogenesis
with
lower
treatment
intensity,
iii)
cells
by
initialization
death
higher
above
all
cancer
cells.
Based
own
published
results
as
well
monitoring
literature
aim
this
topical
review
is
to
summarize
state
art
connect
it
redox
biology.
One
research
insight
that
biological
mainly
mediated
via
reactive
oxygen
nitrogen
species
influencing
cellular
redox-regulated
processes.
can
be
considered
field
applied
