Food Chemistry, Год журнала: 2022, Номер 404, С. 134701 - 134701
Опубликована: Окт. 22, 2022
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)
Опубликована: Сен. 1, 2022
Abstract The current understanding of lactate extends from its origins as a byproduct glycolysis to role in tumor metabolism, identified by studies on the Warburg effect. shuttle hypothesis suggests that plays an important bridging signaling molecule coordinates among different cells, organs and tissues. Lactylation is posttranslational modification initially reported Professor Yingming Zhao’s research group 2019. Subsequent confirmed lactylation vital component function involved proliferation, neural excitation, inflammation other biological processes. An indispensable substance for various physiological cellular functions, regulatory aspects energy metabolism signal transduction. Therefore, comprehensive review summary presented clarify disease provide reference direction future research. This offers systematic overview homeostasis roles pathological processes, well effects diseases, particularly cancer.
Язык: Английский
Процитировано
629
Cells, Год журнала: 2022, Номер 11(23), С. 3843 - 3843
Опубликована: Ноя. 30, 2022
Atherosclerosis is a chronic inflammatory disease of the vascular system and leading cause cardiovascular diseases worldwide. Excessive generation reactive oxygen species (ROS) leads to state oxidative stress which major risk factor for development progression atherosclerosis. ROS are important maintaining health through their potent signalling properties. However, also activate pro-atherogenic processes such as inflammation, endothelial dysfunction altered lipid metabolism. As such, considerable efforts have been made identify characterise sources in blood vessels. Major enzymatic include NADPH oxidases, xanthine oxidase, nitric oxide synthases mitochondrial electron transport chains. The production balanced by ROS-scavenging antioxidant systems may become dysfunctional disease, contributing stress. Changes expression function antioxidants observed human atherosclerosis while vitro vivo animal models provided mechanistic insight into functions. There interest utilising molecules balance stress, yet clinical trials demonstrate any atheroprotective effects these molecules. Here we will review contribution discuss potential strategies ameliorate aspects disease.
Язык: Английский
Процитировано
230
Antioxidants, Год журнала: 2022, Номер 11(1), С. 133 - 133
Опубликована: Янв. 7, 2022
Flavonoids display a broad range of health-promoting bioactivities. Among these, their capacity to act as antioxidants has remained most prominent. The canonical reactive oxygen species (ROS)-scavenging mode the antioxidant action flavonoids relies on high susceptibility phenolic moieties undergo oxidation. As consequence, upon reaction with ROS, is severely compromised. Other phenol-compromising reactions, such those involved in biotransformation flavonoids, can also markedly affect properties. In recent years, however, increasing evidence indicated that, at least for some oxidation residues fact enhance original apparent paradoxical cases, activity arises from pro-oxidant and/or electrophilic character oxidation-derived metabolites and exerted by activating Nrf2-Keap1 pathway, which upregulates cell's endogenous capacity, and/or, preventing activation pro-inflammatory NF-κB pathway. This review focuses effects that oxidative non-oxidative modification groups may have ability resulting promote direct indirect actions. Considering case metabolite quercetin, we offer comprehensive description increasingly supports concept certain phenolics emerges mechanism amplifies An overlooked topic great phytomedicine potential thus unraveled.
Язык: Английский
Процитировано
159
Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 23
Опубликована: Окт. 19, 2022
Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range molecules with oxidizing properties known as ROS. Despite those being implied negatively in aging and numerous diseases, their key role signaling evident. ROS control several biological processes such inflammation, proliferation, cell death. The redox underlying these events one characteristic the new generation scientists aimed at defining environment. potential, which includes balance sources antioxidant system, implies an important target for understanding cells’ fate derived from signaling. In this review, we summarized chemical, balance, signaling, implications aging.
Язык: Английский
Процитировано
158
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Май 25, 2023
Abstract Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in which the airways narrow or collapse during sleep, causing obstructive apnea. The prevalence of OSAS continues to rise worldwide, particularly middle-aged and elderly individuals. mechanism upper airway incompletely understood but associated with several factors, including obesity, craniofacial changes, altered muscle function airway, pharyngeal neuropathy, fluid shifts neck. main characteristics are recurrent pauses respiration, lead intermittent hypoxia (IH) hypercapnia, accompanied by blood oxygen desaturation arousal sharply increases risk diseases. This paper first briefly describes epidemiology, incidence, pathophysiological mechanisms OSAS. Next, alterations relevant signaling pathways induced IH systematically reviewed discussed. For example, can induce gut microbiota (GM) dysbiosis, impair intestinal barrier, alter metabolites. These ultimately secondary oxidative stress, systemic inflammation, sympathetic activation. We then summarize effects on disease pathogenesis, cardiocerebrovascular disorders, neurological metabolic diseases, cancer, reproductive COVID-19. Finally, different therapeutic strategies for caused causes proposed. Multidisciplinary approaches shared decision-making necessary successful treatment future, more randomized controlled trials needed further evaluation define what treatments best specific patients.
Язык: Английский
Процитировано
154
Life, Год журнала: 2021, Номер 11(4), С. 332 - 332
Опубликована: Апрель 10, 2021
Mitochondria are key intracellular organelles involved not only in the metabolic state of cell, but also several cellular functions, such as proliferation, Calcium signaling, and lipid trafficking. Indeed, these characterized by continuous events fission fusion which contribute to dynamic plasticity their network, strongly influenced mitochondrial contacts with other subcellular organelles. Nevertheless, mitochondria release a major amount reactive oxygen species (ROS) inside eukaryotic cells, reported mediate plethora both physiological pathological growth regulation autophagy, apoptosis, metastasis. Therefore, targeting ROS could be promising strategy overcome hinder development diseases cancer, where malignant possessing higher respect healthy ones, specifically targeted therapeutic treatments. In this review, we collected ultimate findings on blended interplay among shaping, ROS, signaling pathways, order dissection molecular mechanisms pathophysiology possibly improving future approaches.
Язык: Английский
Процитировано
131
Antioxidants, Год журнала: 2022, Номер 11(5), С. 801 - 801
Опубликована: Апрель 20, 2022
Calcium is used in many cellular processes and maintained within the cell as free calcium at low concentrations (approximately 100 nM), compared with extracellular (millimolar) concentrations, to avoid adverse effects such phosphate precipitation. For this reason, cells have adapted buffering strategies by compartmentalizing into mitochondria endoplasmic reticulum (ER). In mitochondria, concentration millimolar range, it ER. Mitochondria actively contribute calcium, but if matrix increases beyond physiological demands, can promote opening of mitochondrial permeability transition pore (mPTP) and, consequently, trigger apoptotic or necrotic death. The pathophysiological implications mPTP ischemia-reperfusion, liver, muscle, lysosomal storage diseases, well those affecting central nervous system, for example, Parkinson’s disease (PD), Alzheimer’s (AD), Huntington’s (HD), amyotrophic lateral sclerosis (ALS) been reported. review, we present an updated overview main mechanisms regulation. We specially focus on neurodegenerative diseases related imbalances homeostasis summarize some proposed therapies studied attenuate these diseases.
Язык: Английский
Процитировано
128
Chemosphere, Год журнала: 2021, Номер 288, С. 132607 - 132607
Опубликована: Окт. 20, 2021
Язык: Английский
Процитировано
123
Antioxidants, Год журнала: 2021, Номер 10(9), С. 1442 - 1442
Опубликована: Сен. 10, 2021
Thyroid diseases, including neoplasms, autoimmune diseases and thyroid dysfunctions, are becoming a serious social problem with rapidly increasing prevalence. The latter is increasingly linked to oxidative stress. There many methods for determining the biomarkers of stress, making it possible evaluate profile in patients compared healthy population. This opens up new perspective investigating role elevated parameters stress damage people especially neoplastic nature. An imbalance between oxidants antioxidants observed at different stages types diseases. organ, which part endocrine system, uses free radicals (reactive oxygen species, ROS) produce hormones. cells release enzymes that catalyse ROS generation; therefore, key played by internal defence system non-enzymatic counteract excess not utilised hormones, acting as buffer neutralise ensure whole-body homeostasis. causes structural cell damage, undermining genomic stability. Looking negative effects accumulation, appears be implicated both initiation progression carcinogenesis. aim this review investigate oxidation background summarise links redox dysfunction disease.
Язык: Английский
Процитировано
119
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3264 - 3264
Опубликована: Март 13, 2024
Oxidative stress, characterized by an imbalance favouring oxidants over antioxidants, is a key contributor to the development of various common diseases. Counteracting these considered effective strategy mitigate levels oxidative stress in organisms. Numerous studies have indicated inverse correlation between consumption vegetables and fruits risk chronic diseases, attributing health benefits presence antioxidant phytochemicals foods. Phytochemicals, present wide range foods medicinal plants, play pivotal role preventing treating diseases induced working as antioxidants. These compounds exhibit potent antioxidant, anti-inflammatory, anti-aging, anticancer, protective properties against cardiovascular diabetes mellitus, obesity, neurodegenerative conditions. This comprehensive review delves into significance averting managing elucidating sources invaluable elements. Additionally, it provides summary recent advancements understanding associated with phytochemicals.
Язык: Английский
Процитировано
97