Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Nature Reviews Molecular Cell Biology, Год журнала: 2022, Номер 23(7), С. 499 - 515

Опубликована: Фев. 21, 2022

Язык: Английский

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Alkoxy Radicals See the Light: New Paradigms of Photochemical Synthesis

Chemical Reviews, Год журнала: 2021, Номер 122(2), С. 2429 - 2486

Опубликована: Окт. 6, 2021

Alkoxy radicals are highly reactive species that have long been recognized as versatile intermediates in organic synthesis. However, their development has impeded due to a lack of convenient methods for generation. Thanks advances photoredox catalysis, enabling facile access alkoxy from bench-stable precursors and free alcohols under mild conditions, research interest this field renewed. This review comprehensively summarizes the recent progress radical-mediated transformations visible light irradiation. Elementary steps radical generation either or central reaction development; thus, each section is categorized discussed accordingly. Throughout review, we focused on different mechanisms well impact synthetic utilizations. Notably, catalytic abundant still early stage, providing intriguing opportunities exploit diverse paradigms.

Язык: Английский

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Oxidative eustress: On constant alert for redox homeostasis

Redox Biology, Год журнала: 2021, Номер 41, С. 101867 - 101867

Опубликована: Янв. 20, 2021

In the open metabolic system, redox-related signaling requires continuous monitoring and fine-tuning of steady-state redox set point. The ongoing oxidative metabolism is a persistent challenge, denoted as eustress, which operates within physiological range that has been called 'Homeodynamic Space', 'Goldilocks Zone' or 'Golden Mean'. Spatiotemporal control achieved by compartmentalized generation removal oxidants. cellular landscape H2O2, major molecule, characterized orders-of-magnitude concentration differences between organelles. This pattern mirrored oxidatively modified proteins, exemplified S-glutathionylated proteins. review presents conceptual background for short-term (non-transcriptional) longer-term (transcriptional/translational) homeostatic mechanisms stress responses. point variable moving target value, modulated circadian rhythm external influence, summarily exposome, includes nutrition lifestyle factors. Emerging fields cell-specific tissue-specific regulation in settings are briefly presented, including new insight into role eustress embryonal development lifespan, skeletal muscle exercise, sleep-wake rhythm, function nervous system with aspects leading to psychobiology.

Язык: Английский

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Innate-adaptive immunity interplay and redox regulation in immune response

Redox Biology, Год журнала: 2020, Номер 37, С. 101759 - 101759

Опубликована: Окт. 1, 2020

Innate and adaptive immune cell activation infiltration is the key characteristic of tissue inflammation. The innate system front line host defense in which cells are activated by danger signals, including pathogen- danger-associated molecular pattern, metabolite-associated signal. immunity can directly contribute to inflammation or resolution phagocytosis secretion biologically active molecules, indirectly via antigen-presenting (APC) activation-mediated responses. This review article describes cellular interplay innate-adaptive systems. Three major mechanisms emphasized this for their role facilitating interplay. 1) APC be formed from classical conditional bridge response. 2) Immune checkpoint pairs connect direct one-way two-way reactions. 3) Metabolic reprogramming during responses leads excessive cytosolic mitochondrial reactive oxygen species (ROS) production. Increased NADPH oxidase-derived extracellular intracellular ROS mostly responsible oxidative stress, contributes functional changes cells. Further understanding its underlying basis would lead identification therapeutic targets immunological inflammatory disease.

Язык: Английский

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Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries

Bioactive Materials, Год журнала: 2021, Номер 7, С. 47 - 72

Опубликована: Июнь 20, 2021

Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction, but morbidity and mortality of infarction still high. Reperfusion injuries inevitable due the generation reactive oxygen species (ROS) apoptosis cardiac muscle cells. However, many antioxidant anti-inflammatory drugs largely limited by pharmacokinetics route administration, such as short half-life, low stability, bioavailability, side effects for treatment ischemia injury. Therefore, it is necessary develop effective technologies address this issue. Fortunately, nanotherapies have demonstrated great opportunities treating Compared with traditional drugs, nanodrugs can effectively increase therapeutic effect reduces improving pharmacokinetic pharmacodynamic properties nanodrugs' size, shape, material characteristics. In review, biology ROS molecular mechanisms injury discussed. Furthermore, we summarized applications ROS-based nanoparticles, highlighting latest achievements nanotechnology researches

Язык: Английский

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Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection

Journal of Advanced Research, Год журнала: 2021, Номер 38, С. 223 - 244

Опубликована: Сен. 17, 2021

Recent research on the implications of gut microbiota brain functions has helped to gather important information relationship between them. Pathogenesis neurological disorders is found be associated with dysregulation gut-brain axis. Some bacteria metabolites are directly increase in reactive oxygen species levels, one most risk factors neurodegeneration. Besides their morbid association, also play a significant role reducing onset these life-threatening disorders.Studies done recent past raises two link and brain: "gut microbiota-oxidative stress-neurodegeneration" microbiota-antioxidant-neuroprotection. This review aims gives deep insight our readers, collective studies done, focusing mediated oxidative stress involved neurodegeneration along focus those showing involvement neuroprotection.This focused three main key concepts. Firstly, mounting evidences from clinical preclinical arenas shows influence resulting dysfunctional processes. Therefore, we describe potential influencing vulnerability stress, budding causative Alzheimer's Parkinson's disease. Secondly, contributing roles been observed attenuating inflammation via its own or by producing secondary and, modulation population antioxidative anti-inflammatory probiotics have shown promising neuro resilience. Thirdly, high throughput silico tools databases correlation microbiome, health, thus providing fascinating perspective new avenues for therapeutic options.

Язык: Английский

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Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction

Cell stem cell, Год журнала: 2021, Номер 29(2), С. 281 - 297.e12

Опубликована: Ноя. 10, 2021

Язык: Английский

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Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation

Antioxidants, Год журнала: 2022, Номер 11(2), С. 408 - 408

Опубликована: Фев. 17, 2022

Free radicals are formed as a part of normal metabolic activities but neutralized by the endogenous antioxidants present in cells/tissue, thus maintaining redox balance. This balance is disrupted certain neuropathophysiological conditions, causing oxidative stress, which implicated several progressive neurodegenerative diseases. Following neuronal injury, secondary injury progression also caused excessive production free radicals. Highly reactive radicals, mainly oxygen species (ROS) and nitrogen (RNS), damage cell membrane, proteins, DNA, triggers self-propagating inflammatory cascade degenerative events. Dysfunctional mitochondria under stress conditions considered key mediator neurodegeneration. Exogenous delivery holds promise to alleviate regain In this regard, natural synthetic have been evaluated. Despite promising results preclinical studies, clinical translation therapy treat diseases remains elusive. The issues could be their low bioavailability, instability, limited transport target tissue, and/or poor antioxidant capacity, requiring repeated high dosing, cannot administered humans because dose-limiting toxicity. Our laboratory investigating nanoparticle-mediated enzymes address some above issues. Apart from being endogenous, main advantage catalytic mechanism action; hence, they significantly more effective at lower doses detoxifying deleterious effects than nonenzymatic antioxidants. review provides comprehensive analysis potential therapy, challenges translation, role nanoparticles/drug systems play addressing these challenges.

Язык: Английский

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Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury

Free Radical Biology and Medicine, Год журнала: 2021, Номер 165, С. 24 - 37

Опубликована: Янв. 21, 2021

The heart is the most metabolically flexible organ with respect to use of substrates available in different states energy metabolism. Cardiac mitochondria sense substrate availability and ensure efficiency oxidative phosphorylation function. Mitochondria also play a critical role cardiac ischemia/reperfusion injury, during which they are directly involved ROS-producing pathophysiological mechanisms. This review explores mechanisms ROS production within metabolism pathways focuses on impact substrates. We describe main metabolites accumulating ischemia glucose, fatty acid, Krebs cycle pathways. Hyperglycemia, often present acute stress condition ischemia/reperfusion, increases cytosolic concentrations through activation NADPH oxidase 2 mitochondrial metabolic overloading decreased binding hexokinase II mitochondria. Fatty acid-linked related increased acid flux corresponding accumulation long-chain acylcarnitines. Succinate that accumulates anoxia/ischemia suggested be source ROS, itaconate as an inhibitor succinate dehydrogenase emerging. discuss strategies modulate counteract yield therapeutic implications this concept.

Язык: Английский

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Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis

Cells, Год журнала: 2021, Номер 11(1), С. 30 - 30

Опубликована: Дек. 23, 2021

Mitochondria are multifunctional subcellular organelles essential for cellular energy homeostasis and apoptotic cell death. It is, therefore, crucial to maintain mitochondrial fitness. Mitophagy, the selective removal of dysfunctional mitochondria by autophagy, is critical regulating quality control in many physiological processes, including development differentiation. On other hand, both impaired excessive mitophagy involved pathogenesis different ageing-associated diseases such as neurodegeneration, cancer, myocardial injury, liver disease, sarcopenia diabetes. The best-characterized pathway PTEN-induced putative kinase 1 (PINK1)/Parkin-dependent pathway. However, Parkin-independent pathways also reported mediate tethering autophagy apparatuses, directly activating (mitophagy receptors E3 ligases). In addition, existence molecular mechanisms than PINK1-mediated phosphorylation Parkin activation was proposed. adenosine5′-monophosphate (AMP)-activated protein (AMPK) emerging a key player metabolism mitophagy. Beyond its involvement fission autophagosomal engulfment, interplay with PINK1–Parkin reported. Here, we review recent advances elucidating canonical signaling that regulate mitophagy, focusing on early role spatial specificity AMPK/ULK1 axis.

Язык: Английский

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