Toxicon,
Год журнала:
2025,
Номер
260, С. 108366 - 108366
Опубликована: Апрель 17, 2025
Matrine,
the
main
active
ingredient
in
Sophora
flavescens
and
Sophorae
tonkinensis
radix
et
rhizome,
is
a
highly
effective
insecticide.
However,
its
hepatotoxicity
to
some
extent
affects
application
value.
This
study
aimed
explore
mechanism
underlying
matrine-induced
liver
injury.
The
zebrafish
(Danio
rerio)
L02
cell
model
were
utilized
investigate
toxic
dose
of
matrine
effects
on
tissue
damage,
morphology
activity,
expression
levels
ALT
AST.
Zebrafish
samples
then
collected
for
transcriptomic
testing
further
possible
by
which
induced
Finally,
integrated
bioinformatics
methods
experiments
used
elucidate
mechanisms
behind
result
presented
solid
vivo
evidence
hepatotoxicity,
supported
abnormal
changes
morphological,
disturbed
structure,
obvious
apoptosis,
as
well
elevated
AST
zebrafish.
In
addition,
vitro
also
showed
that
can
produce
significant
damage
effects.
analysis
results
revealed
differentially
expressed
genes
(DEGs)
substantially
enriched
multiple
pathways
related
lipid
regulation.
Among
which,
steroid
biosynthesis
was
most
key
signaling
pathway,
evidenced
enhanced
eight
genes,
including
DHCR7,
SQLE,
CYP51,
CYP24A1,
SC5D,
LSS,
MSMO1
SOAT1.
Furthermore,
AY9944,
targeted
inhibitor
could
offset
effect,
reflected
diminished
phenotype
steatosis,
cholesterol
accumulation
caused
matrine.
Matrine
upregulate
resulting
inducing
hepatotoxicity.
them,
inhibition
DHCR7
gene
alleviate
Nutrients,
Год журнала:
2025,
Номер
17(2), С. 320 - 320
Опубликована: Янв. 17, 2025
With
the
improvement
of
living
standards,
alcoholic
liver
disease
caused
by
long-term
drinking
has
been
a
common
multiple
disease.
Probiotic
interventions
may
help
mitigate
damage
alcohol
intake,
but
mechanisms
need
more
investigation.
This
study
involved
70
drinkers
(18-65
years
old,
consumption
≥20
g/day,
lasting
for
than
one
year)
who
were
randomly
assigned
to
either
BC99
group
or
placebo
group.
Two
groups
given
(3
1
×
1010
CFU)
g/day)
60
days,
respectively.
Before
and
after
intervention,
blood
routine
indicators,
function,
renal
inflammatory
factors
intestinal
flora
evaluated.
The
results
showed
that
intervention
with
Weizmannia
coagulans
reduced
levels
alanine
aminotransferase,
aspartate
glutamyl
transpeptidase,
serum
total
bilirubin,
urea
nitrogen,
uric
acid
'blood
nitrogen/creatinine'.
also
pro-inflammatory
TNF-α
IL-6
increased
anti-inflammatory
factor
IL-10.
analysis
regulated
imbalance
flora,
beneficial
bacteria
abundance
(Prevotella,
Faecalibacterium
Roseburia)
conditionally
pathogenic
(Escherichia-Shigella
Klebsiella).
Both
LEfSe
random
forest
indicated
increase
in
Muribaculaceae
induced
was
key
alleviating
alcohol-induced
damage.
These
findings
demonstrate
potential
alleviate
injury
provide
an
effective
strategy
protection
drinkers.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(9), С. 3834 - 3854
Опубликована: Июнь 3, 2024
Immunotherapy
is
an
important
cancer
treatment
method
that
offers
hope
for
curing
patients.
While
immunotherapy
has
achieved
initial
success,
a
major
obstacle
to
its
widespread
adoption
the
inability
benefit
majority
of
The
success
or
failure
closely
linked
tumor's
immune
microenvironment.
Recently,
there
been
significant
attention
on
strategies
regulate
tumor
microenvironment
in
order
stimulate
anti-tumor
responses
immunotherapy.
distinctive
physical
properties
and
design
flexibility
nanomedicines
have
extensively
utilized
target
cells
(including
tumor-associated
macrophages
(TAMs),
T
cells,
myeloid-derived
suppressor
(MDSCs),
fibroblasts
(TAFs)),
offering
promising
advancements
In
this
article,
we
reviewed
aimed
at
targeting
various
focus
models
are
based
nanomedicines,
with
goal
inducing
enhancing
improve
It
worth
noting
combining
other
treatments,
such
as
chemotherapy,
radiotherapy,
photodynamic
therapy,
can
maximize
therapeutic
effects.
Finally,
identified
challenges
nanotechnology-mediated
needs
overcome
more
effective
nanosystems.
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Март 20, 2024
Abstract
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
one
of
the
leading
causes
chronic
diseases,
affecting
more
than
one-quarter
people
worldwide.
Hepatic
steatosis
can
progress
to
severe
forms
NAFLD,
including
NASH
and
cirrhosis.
It
also
may
develop
secondary
diseases
such
as
diabetes
cardiovascular
disease.
Genetic
environmental
factors
regulate
NAFLD
incidence
progression,
making
it
a
complex
The
contribution
various
risk
factors,
type
2
diabetes,
obesity,
hyperlipidemia,
diet,
sedentary
lifestyle,
exacerbation
injury
highly
understood.
Nevertheless,
underlying
mechanisms
genetic
variations
in
occurrence
or
its
deterioration
still
need
be
clarified.
Hence,
understanding
susceptibility
essential
for
controlling
course
current
review
discusses
genetics’
role
pathological
pathways
lipid
glucose
metabolism,
insulin
resistance,
cellular
stresses,
immune
responses.
Additionally,
explains
components
induction
progression
lean
individuals.
Finally,
highlights
utility
knowledge
precision
medicine
early
diagnosis
treatment
patients.
World Journal of Hepatology,
Год журнала:
2024,
Номер
16(4), С. 566 - 600
Опубликована: Апрель 24, 2024
The
unique
physicochemical
properties
inherent
to
nanoscale
materials
have
unveiled
numerous
potential
applications,
spanning
beyond
the
pharmaceutical
and
medical
sectors
into
various
consumer
industries
like
food
cosmetics.
Consequently,
humans
encounter
nanomaterials
through
diverse
exposure
routes,
giving
rise
health
considerations.
Noteworthy
among
these
are
silica
specific
metallic
nanoparticles,
extensively
utilized
in
products,
which
garnered
substantial
attention
due
their
propensity
accumulate
induce
adverse
effects
liver.
This
review
paper
aims
provide
an
exhaustive
examination
of
molecular
mechanisms
underpinning
nanomaterial-induced
hepatotoxicity,
drawing
insights
from
both
vitro
vivo
studies.
Primarily,
most
frequently
observed
manifestations
toxicity
following
cells
or
animal
models
involve
initiation
oxidative
stress
inflammation.
Additionally,
we
delve
existing
employed
for
evaluating
hepatotoxic
nanomaterials,
emphasizing
persistent
endeavors
advance
bolster
reliability
nanotoxicology
research.
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Март 10, 2025
Abstract
The
ability
of
small
nucleic
acids
to
modulate
gene
expression
via
a
range
processes
has
been
widely
explored.
Compared
with
conventional
treatments,
acid
therapeutics
have
the
potential
achieve
long-lasting
or
even
curative
effects
editing.
As
result
recent
technological
advances,
efficient
delivery
for
therapeutic
and
biomedical
applications
achieved,
accelerating
their
clinical
translation.
Here,
we
review
increasing
number
classes
most
common
chemical
modifications
platforms.
We
also
discuss
key
advances
in
design,
development
application
each
platform.
Furthermore,
this
presents
comprehensive
profiles
currently
approved
drugs,
including
11
antisense
oligonucleotides
(ASOs),
2
aptamers
6
siRNA
summarizing
modifications,
disease-specific
mechanisms
action
strategies.
Other
candidates
whose
trial
status
recorded
updated
are
discussed.
consider
strategic
issues
such
as
important
safety
considerations,
novel
vectors
hurdles
translating
academic
breakthroughs
clinic.
Small
produced
favorable
results
trials
address
previously
“undruggable”
targets,
suggesting
that
they
could
be
useful
guiding
additional
candidates.
Frontiers in Medicine,
Год журнала:
2023,
Номер
10
Опубликована: Апрель 20, 2023
In
recent
years,
the
prevalence
of
metabolic-associated
fatty
liver
disease
(MAFLD)
has
reached
pandemic
proportions
as
a
leading
cause
fibrosis
worldwide.
However,
stage
is
associated
with
an
increased
risk
severe
liver-related
and
cardiovascular
events
strongest
predictor
mortality
in
MAFLD
patients.
More
more
people
believe
that
multifactorial
multiple
pathways
are
involved
promoting
progression
fibrosis.
Numerous
drug
targets
drugs
have
been
explored
for
various
anti-fibrosis
pathways.
The
treatment
single
medicines
brutal
to
obtain
satisfactory
results,
so
strategies
multi-drug
combination
therapies
attracted
increasing
attention.
this
review,
we
discuss
mechanism
MAFLD-related
its
regression,
summarize
current
intervention
methods
disease,
focus
on
analysis
subsequent
years
explore
safer
effective
therapy
strategies.
Poultry Science,
Год журнала:
2024,
Номер
103(7), С. 103817 - 103817
Опубликована: Май 1, 2024
Cadmium
(Cd)
is
a
common
environmental
pollutant
associated
with
an
increased
incidence
of
renal
metabolic
diseases.
Luteolin
(Lut),
natural
flavonoid,
widely
used
for
its
multifaceted
therapeutic
properties
in
inflammatory
However,
whether
Lut
protects
against
Cd-induced
nephrotoxicity
still
equivocal.
The
present
study
investigated
the
effects
supplementation
on
oxidative
stress,
inflammation
and
metabolism
their
related
mechanisms.
Therefore,
40
chickens
were
treated
Cd
and/or
automatic
water
free
food
intake
1
mo
then
kidney
tissues
collected
to
explore
this
issue.
In
study,
exposure
induced
glycolipid
disorders
resultant
damage
by
periodic
acid
Schiff
(PAS)
staining,
Oil
Red
O
total
cholesterol
(TC),
triglyceride
(TG),
glucose
(Glu)
levels
kidney,
which
significantly
ameliorated
Lut.
Moreover,
also
normalized
expression
factors
Cd-disturbed
metabolism,
improving
homeostasis,
contributing
alleviating
damage.
Furthermore,
demonstrated
potential
stress
enhancing
antioxidant
capacity
inhibiting
cytokine
production
tissues.
Mechanistically,
activated
AMPK/SIRT1/FOXO1
signaling
pathway,
attenuating
responses,
ameliorating
disturbance.
conclusion,
these
observations
demonstrate
that
treatment
activates
decreases
response,
may
contribute
prevent
disorder
consequent
