Enhancing cancer immunotherapy: Nanotechnology-mediated immunotherapy overcoming immunosuppression

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3834 - 3854

Published: June 3, 2024

Immunotherapy is an important cancer treatment method that offers hope for curing patients. While immunotherapy has achieved initial success, a major obstacle to its widespread adoption the inability benefit majority of The success or failure closely linked tumor's immune microenvironment. Recently, there been significant attention on strategies regulate tumor microenvironment in order stimulate anti-tumor responses immunotherapy. distinctive physical properties and design flexibility nanomedicines have extensively utilized target cells (including tumor-associated macrophages (TAMs), T cells, myeloid-derived suppressor (MDSCs), fibroblasts (TAFs)), offering promising advancements In this article, we reviewed aimed at targeting various focus models are based nanomedicines, with goal inducing enhancing improve It worth noting combining other treatments, such as chemotherapy, radiotherapy, photodynamic therapy, can maximize therapeutic effects. Finally, identified challenges nanotechnology-mediated needs overcome more effective nanosystems.

Language: Английский

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Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: March 20, 2024

Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes chronic diseases, affecting more than one-quarter people worldwide. Hepatic steatosis can progress to severe forms NAFLD, including NASH and cirrhosis. It also may develop secondary diseases such as diabetes cardiovascular disease. Genetic environmental factors regulate NAFLD incidence progression, making it a complex The contribution various risk factors, type 2 diabetes, obesity, hyperlipidemia, diet, sedentary lifestyle, exacerbation injury highly understood. Nevertheless, underlying mechanisms genetic variations in occurrence or its deterioration still need be clarified. Hence, understanding susceptibility essential for controlling course current review discusses genetics’ role pathological pathways lipid glucose metabolism, insulin resistance, cellular stresses, immune responses. Additionally, explains components induction progression lean individuals. Finally, highlights utility knowledge precision medicine early diagnosis treatment patients.

Language: Английский

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Molecular mechanism of nanomaterials induced liver injury: A review

World Journal of Hepatology, Journal Year: 2024, Volume and Issue: 16(4), P. 566 - 600

Published: April 24, 2024

The unique physicochemical properties inherent to nanoscale materials have unveiled numerous potential applications, spanning beyond the pharmaceutical and medical sectors into various consumer industries like food cosmetics. Consequently, humans encounter nanomaterials through diverse exposure routes, giving rise health considerations. Noteworthy among these are silica specific metallic nanoparticles, extensively utilized in products, which garnered substantial attention due their propensity accumulate induce adverse effects liver. This review paper aims provide an exhaustive examination of molecular mechanisms underpinning nanomaterial-induced hepatotoxicity, drawing insights from both vitro vivo studies. Primarily, most frequently observed manifestations toxicity following cells or animal models involve initiation oxidative stress inflammation. Additionally, we delve existing employed for evaluating hepatotoxic nanomaterials, emphasizing persistent endeavors advance bolster reliability nanotoxicology research.

Language: Английский

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Nanomaterial grouping: Unraveling the relationship of induced mechanisms and potency at a temporal scale

Nano Today, Journal Year: 2025, Volume and Issue: 61, P. 102639 - 102639

Published: Jan. 15, 2025

Language: Английский

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The Improvement Effects of Weizmannia coagulans BC99 on Liver Function and Gut Microbiota of Long-Term Alcohol Drinkers: A Randomized Double-Blind Clinical Trial

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 320 - 320

Published: Jan. 17, 2025

With the improvement of living standards, alcoholic liver disease caused by long-term drinking has been a common multiple disease. Probiotic interventions may help mitigate damage alcohol intake, but mechanisms need more investigation. This study involved 70 drinkers (18-65 years old, consumption ≥20 g/day, lasting for than one year) who were randomly assigned to either BC99 group or placebo group. Two groups given (3 1 × 1010 CFU) g/day) 60 days, respectively. Before and after intervention, blood routine indicators, function, renal inflammatory factors intestinal flora evaluated. The results showed that intervention with Weizmannia coagulans reduced levels alanine aminotransferase, aspartate glutamyl transpeptidase, serum total bilirubin, urea nitrogen, uric acid 'blood nitrogen/creatinine'. also pro-inflammatory TNF-α IL-6 increased anti-inflammatory factor IL-10. analysis regulated imbalance flora, beneficial bacteria abundance (Prevotella, Faecalibacterium Roseburia) conditionally pathogenic (Escherichia-Shigella Klebsiella). Both LEfSe random forest indicated increase in Muribaculaceae induced was key alleviating alcohol-induced damage. These findings demonstrate potential alleviate injury provide an effective strategy protection drinkers.

Language: Английский

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A Mitochondria-Targeted Nanozyme with Enhanced Antioxidant Activity to Prevent Acute Liver Injury by Remodeling Mitochondria Respiratory Chain

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123133 - 123133

Published: Jan. 1, 2025

Language: Английский

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Warning on the inhalation of silica nanoparticles: experimental evidence for its easy passage through the air-blood barrier, resulting in systemic distribution and pathological injuries

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111423 - 111423

Published: Feb. 1, 2025

Language: Английский

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Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 10, 2025

Abstract The ability of small nucleic acids to modulate gene expression via a range processes has been widely explored. Compared with conventional treatments, acid therapeutics have the potential achieve long-lasting or even curative effects editing. As result recent technological advances, efficient delivery for therapeutic and biomedical applications achieved, accelerating their clinical translation. Here, we review increasing number classes most common chemical modifications platforms. We also discuss key advances in design, development application each platform. Furthermore, this presents comprehensive profiles currently approved drugs, including 11 antisense oligonucleotides (ASOs), 2 aptamers 6 siRNA summarizing modifications, disease-specific mechanisms action strategies. Other candidates whose trial status recorded updated are discussed. consider strategic issues such as important safety considerations, novel vectors hurdles translating academic breakthroughs clinic. Small produced favorable results trials address previously “undruggable” targets, suggesting that they could be useful guiding additional candidates.

Language: Английский

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Liver fibrosis and MAFLD: the exploration of multi-drug combination therapy strategies

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: April 20, 2023

In recent years, the prevalence of metabolic-associated fatty liver disease (MAFLD) has reached pandemic proportions as a leading cause fibrosis worldwide. However, stage is associated with an increased risk severe liver-related and cardiovascular events strongest predictor mortality in MAFLD patients. More more people believe that multifactorial multiple pathways are involved promoting progression fibrosis. Numerous drug targets drugs have been explored for various anti-fibrosis pathways. The treatment single medicines brutal to obtain satisfactory results, so strategies multi-drug combination therapies attracted increasing attention. this review, we discuss mechanism MAFLD-related its regression, summarize current intervention methods disease, focus on analysis subsequent years explore safer effective therapy strategies.

Language: Английский

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Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney

Poultry Science, Journal Year: 2024, Volume and Issue: 103(7), P. 103817 - 103817

Published: May 1, 2024

Cadmium (Cd) is a common environmental pollutant associated with an increased incidence of renal metabolic diseases. Luteolin (Lut), natural flavonoid, widely used for its multifaceted therapeutic properties in inflammatory However, whether Lut protects against Cd-induced nephrotoxicity still equivocal. The present study investigated the effects supplementation on oxidative stress, inflammation and metabolism their related mechanisms. Therefore, 40 chickens were treated Cd and/or automatic water free food intake 1 mo then kidney tissues collected to explore this issue. In study, exposure induced glycolipid disorders resultant damage by periodic acid Schiff (PAS) staining, Oil Red O total cholesterol (TC), triglyceride (TG), glucose (Glu) levels kidney, which significantly ameliorated Lut. Moreover, also normalized expression factors Cd-disturbed metabolism, improving homeostasis, contributing alleviating damage. Furthermore, demonstrated potential stress enhancing antioxidant capacity inhibiting cytokine production tissues. Mechanistically, activated AMPK/SIRT1/FOXO1 signaling pathway, attenuating responses, ameliorating disturbance. conclusion, these observations demonstrate that treatment activates decreases response, may contribute prevent disorder consequent

Language: Английский

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