Agriculture,
Год журнала:
2023,
Номер
13(12), С. 2250 - 2250
Опубликована: Дек. 7, 2023
Soybean
fat
contains
five
principal
fatty
acids,
and
its
acid
composition
nutritional
value
depend
on
the
type
of
soybean
oil,
storage
duration,
conditions.
Among
contents,
polyunsaturated
such
as
linoleic
linolenic
acid,
play
an
essential
role
in
maintaining
human
life
activities;
thus,
increasing
proportions
contents
can
help
improve
oil.
Our
laboratory
completed
SLAF-seq
whole
genome
sequencing
natural
population
(292
varieties)
previous
growth
period.
In
this
study,
genome-wide
association
analysis
(GWAS)
was
performed
based
genotypic
data
three-year
phenotypic
a
significant
single
nucleotide
polymorphisms
(SNPs)
locus
(Gm13_10009679)
associated
with
oleic
content
repeatedly
detected
over
span
3
years
using
GLM
model
MLM
model.
Additionally,
another
SNP
(Gm19_41366844)
correlated
identified
through
same
models.
Genes
within
100
Kb
interval
upstream
downstream
loci
were
scanned
analyzed
for
their
functional
annotation
enrichment,
one
gene
related
to
synthesis
(Glyma.13G035600)
(Glyma.19G147400)
screened.
The
expressions
candidate
genes
verified
qRT-PCR,
verification
results,
it
hypothesized
that
Glyma.13G035600
Glyma.19G147400
positively
regulate
accumulation,
respectively.
above
study
lays
foundation
further
validating
functions,
analyzing
regulatory
mechanisms
accumulation
soybean.
Frontiers in Immunology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 24, 2024
Introduction
Vascular
smooth
muscle
cells
(VSMCs)
are
the
predominant
cell
type
in
medial
layer
of
aorta,
which
plays
a
critical
role
aortic
diseases.
Innate
immunity
is
main
driving
force
for
cardiovascular
Methods
To
determine
roles
innate
VSMC
and
pathologies,
we
performed
transcriptome
analyses
on
aortas
from
ApoE
–/–
angiotensin
II
(Ang
II)-induced
aneurysm
(AAA)
time
course,
atherosclerosis
as
well
VSMCs
stimulated
with
danger-associated
molecular
patterns
(DAMPs).
Results
We
made
significant
findings:
1)
95%
45%
upregulated
immune
pathways
(UIIPs,
based
data
1226
genes)
Ang
II-induced
AAA
at
7
days
were
different
that
14
28
days,
respectively;
showed
twin
peaks
UIIPs
major
peak
minor
days;
2)
all
6
weeks
32
78
(two
waves);
3)
additional
12
lists
immune-related
genes
1325
cytokine
chemokine
genes,
2022
plasma
membrane
protein
373
clusters
differentiation
(CD)
marker
280
nuclear
1425
nucleoli
6750
nucleoplasm
1496
transcription
factors
(TFs)
including
15
pioneer
TFs,
164
histone
modification
enzymes,
102
oxidative
death
68
necrotic
47
efferocytosis
confirmed
two-wave
inflammation
twin-peak
AAA;
4)
DAMPs-stimulated
judged
by
upregulation
lists;
5)
increased
trans-differentiation
potential
upregulating
not
only
some
82
markers
VSMC-plastic
types,
fibroblast,
osteogenic,
myofibroblast,
macrophage,
adipocyte,
foam
cell,
mesenchymal
but
also
18
new
types
(out
79
human
8065
markers);
6)
analysis
gene
deficient
transcriptomes
indicated
antioxidant
factor
NRF2
suppresses,
however,
other
five
inflammatory
master
regulators,
AHR,
NF-KB,
NOX
(ROS
enzyme),
PERK,
SET7
promote
twelve
atherosclerosis,
AAA,
DAMP-stimulated
VSMCs;
7)
both
trained
tolerance-promoting
metabolite
itaconate
contributed
to
cytokines
AAA.
Discussion
Our
findings
have
provided
novel
insights
responses
stresses
development
immunology
therapeutic
targets
treating
those
cerebrovascular
Redox Biology,
Год журнала:
2024,
Номер
76, С. 103331 - 103331
Опубликована: Авг. 29, 2024
Mitochondria,
traditionally
recognized
as
cellular
'powerhouses'
due
to
their
pivotal
role
in
energy
production,
have
emerged
multifunctional
organelles
at
the
intersection
of
bioenergetics,
metabolic
signaling,
and
immunity.
However,
understanding
exact
contributions
immunity
inflammation
is
still
developing.
This
review
first
introduces
innovative
concept
intracellular
immunity,
emphasizing
how
mitochondria
serve
critical
immune
signaling
hubs.
They
are
instrumental
recognizing
responding
pathogen
danger
signals,
modulating
responses.
We
also
propose
leading
organelles,
drawing
parallels
with
broader
system
functions
antigen
presentation,
regulation,
response.
Our
comprehensive
explores
mitochondrial
pathways,
therapeutic
potential
managing
chronic
diseases,
discusses
cutting-edge
methodologies
for
research.
Targeting
a
broad
readership
both
experts
newcomers
field,
this
sets
forth
new
directions
that
could
transform
our
integrated
organelles.
Journal of Alzheimer s Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
Background
Alzheimer's
disease
(AD)
is
a
neurodegenerative
disorder
characterized
by
memory
impairment.
Neuroinflammatory
processes,
mediated
glial
and
immune
cells,
contribute
to
neuronal
damage.
Emerging
evidence
implicates
innate
mechanisms,
including
trained
immunity
cell
trans-differentiation,
in
AD
pathogenesis,
though
their
roles
remain
unclear.
Objective
To
investigate
transcriptomic
changes
the
3xTg-AD
mouse
model,
focusing
on
trans-differentiation
mechanisms.
Methods
RNA-sequencing
was
performed
brain
tissue
(cortex
plus
hippocampus)
from
11-month-old
female
wild-type
mice
(n
=
3/group).
Differentially
expressed
genes
(fold
change
>
1.5,
p
<
0.05)
were
identified
followed
bioinformatics
knowledge-based
profiling.
Public
datasets
also
analyzed.
Results
exhibited
316
upregulated
412
downregulated
genes.
Downregulated
included
those
for
blood-brain
barrier
protein,
while
related
cerebrospinal
fluid.
Increased
expression
of
proinflammatory
markers,
as
well
differentiation,
proliferation,
activation,
adhesion.
Upregulation
associated
with
migration
suggests
potential
role
inflammation
cellular
plasticity.
Additionally,
involved
inflammasome
pathways,
immunometabolism,
upregulated.
Mechanistically,
these
modulated
knockdown
promoter
SET-7,
overexpression
inhibitor
IL-37,
knockout
IL-1
receptor,
caspase-1,
pattern
recognition
receptor
CD36.
Conclusions
The
finding
underscore
AD,
revealing
mechanistic
framework
which
danger-associated
molecular
patterns
drive
responses,
plasticity
offering
therapeutic
targets
neuroinflammation
reprograming.
International Journal of Drug Discovery and Pharmacology,
Год журнала:
2024,
Номер
unknown, С. 100022 - 100022
Опубликована: Ноя. 26, 2024
Although
previous
reviews
explored
the
roles
of
selected
immune
checkpoints
(ICPs)
in
cardiovascular
diseases
(CVD)
and
cerebrovascular
from
various
perspectives,
many
related
aspects
have
yet
to
be
thoroughly
reviewed
analyzed.
Our
comprehensive
review
addresses
this
gap
by
discussing
cellular
functions
ICPs,
focusing
on
tissue-specific
microenvironment-localized
transcriptomic
posttranslational
regulation
ICP
expressions,
as
well
their
functional
interactions
with
metabolic
reprogramming.
We
also
analyze
how
14
pairs
including
CTLA-4/CD86-CD80,
PD1-PDL-1,
TIGIT-CD155,
regulate
CVD
pathogenesis.
Additionally,
covers
ICPs
modulating
CD4+Foxp3+
regulatory
T
cells
(Tregs),
cells,
innate
CVDs
diseases.
Furthermore,
we
outline
seven
immunological
principles
guide
development
new
ICP-based
therapies
for
CVDs.
This
timely
thorough
analysis
recent
advancements
challenges
provide
insights
into
role
CVDs,
Tregs,
will
support
novel
therapeutics
strategies
these
Metabolites,
Год журнала:
2024,
Номер
14(8), С. 438 - 438
Опубликована: Авг. 6, 2024
Hyperlipidemia
is
a
lipid
metabolism
disorder
that
refers
to
increased
levels
of
total
triglycerides
(TGs),
cholesterol
(TC),
and
low-density
lipoprotein-cholesterol
(LDL-C)
decreased
high-density
(HDL-C).
It
major
public
health
issue
with
prevalence
incidence
worldwide.
The
ability
identify
individuals
at
risk
this
before
symptoms
manifest
will
facilitate
timely
intervention
management
avert
potential
complications.
This
can
be
achieved
by
employing
metabolomics
as
an
early
detection
method
for
the
diagnostic
biomarkers
hyperlipidemia.
Metabolomics
analytical
approach
used
detect
quantify
metabolites.
provides
explain
metabolic
processes
involved
in
development
progression
certain
diseases.
In
recent
years,
interest
use
disease
has
increased,
several
have
been
discovered,
such
docosahexaenoic
acid,
glycocholic
citric
betaine,
carnitine.
review
discusses
primary
alterations
context
Furthermore,
we
provide
overview
studies
on
application
assessment
efficacy
traditional
herbal
products
common
lipid-lowering
medications.
Frontiers in Cardiovascular Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 26, 2024
Pathological
transdifferentiation,
where
differentiated
cells
aberrantly
transform
into
other
cell
types
that
exacerbate
disease
rather
than
promote
healing,
represents
a
novel
and
significant
concept.
This
perspective
discusses
its
role
potential
targeting
in
cardiovascular
diseases
chronic
inflammation.
Current
therapies
mainly
focus
on
mitigating
early
inflammatory
response
through
proinflammatory
cytokines
pathways
targeting,
including
corticosteroids,
TNF-α
inhibitors,
IL-1β
monoclonal
antibodies
blockers,
IL-6
nonsteroidal
anti-inflammatory
drugs
(NSAIDs),
along
with
modulating
innate
immune
memory
(trained
immunity).
However,
these
approaches
often
fail
to
address
long-term
tissue
damage
functional
regeneration.
For
instance,
fibroblasts
can
transdifferentiate
myofibroblasts
cardiac
fibrosis,
endothelial
may
undergo
mesenchymal
transition
(EndMT)
vascular
remodeling,
resulting
fibrosis
impaired
function.
Targeting
pathological
transdifferentiation
promising
therapeutic
avenue
by
focusing
key
signaling
drive
aberrant
cellular
phenotypic
transcriptomic
transitions.
approach
seeks
inhibit
or
modulate
plasticity
effective
regeneration
prevent
fibrosis.
Such
strategies
have
the
inflammation,
death,
damage,
providing
more
comprehensive
sustainable
treatment
solution.
Future
research
should
understanding
mechanisms
behind
identifying
relevant
biomarkers
master
regulators,
developing
preclinical
clinical
trials.
Integrating
new
existing
treatments
could
enhance
efficacy
improve
patient
outcomes.
Highlighting
as
target
paradigms,
leading
better
management
recovery
of
tissues
