Mangiferin mitigates neurological deficits and ferroptosis via NRF2/ARE pathway activation in cerebral ischemia-reperfusion rats DOI Creative Commons

Chenjia Peng,

Yang Zhang,

Jiaqing Chai

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Май 22, 2025

Ferroptosis is a newly described form of nonapoptotic, iron-dependent cell death that plays an essential role in the pathogenesis ischemic stroke. Targeting ferroptosis may be effective way to treat Mangiferin (MGF) natural polyphenol has been shown protect neurological function via multiple mechanisms. However, mechanism by which MGF inhibits stroke remains unclear. An rat model was established middle cerebral artery occlusion. Neurological scoring, TTC staining, behavioral tests, Nissl HE staining and immunochemistry were used analyze influences on deficits, infarct area, cognitive function, neuronal morphology, histopathological injury, morphology microglia astrocytes. Transmission electron microscopy Perls' stain evaluate characteristics ferroptosis. Western blotting expression NRF2, FTL, SLC7A11 GPX4. ELISA levels cytokines, including IL-6, IL-1β TNF-α, neuroinflammation. Oxidative stress evaluated analyzing ROS, MDA, GSH, SOD. clearly improved learning memory ability rats. significantly decreased ROS MDA increased suppressed neuroinflammation downregulating TNF-α. rats inhibited MGF. The NRF2 inhibitor ML385 reversed effects protects suppresses activating NRF2/ARE pathway

Язык: Английский

The Role of Solute Carrier Family Transporters in Hepatic Steatosis and Hepatic Fibrosis DOI Open Access
Chi Zhang,

X Yang,

Yi Xue

и другие.

Journal of Clinical and Translational Hepatology, Год журнала: 2025, Номер 000(000), С. 000 - 000

Опубликована: Янв. 22, 2025

Solute carrier (SLC) family transporters are crucial transmembrane proteins responsible for transporting various molecules, including amino acids, electrolytes, fatty and nucleotides. To date, more than fifty SLC transporter subfamilies have been identified, many of which linked to the progression hepatic steatosis fibrosis. These conditions often caused by factors such as non-alcoholic liver disease steatohepatitis, major contributors global burden. The activity members regulates transport substrates across biological membranes, playing key roles in lipid synthesis metabolism, mitochondrial function, ferroptosis. processes, turn, influence function hepatocytes, stellate cells, macrophages, thereby contributing development Additionally, some involved drug transport, acting critical regulators drug-induced steatosis. Beyond substrate certain also exhibit additional functions. Given pivotal role fibrosis, this review aimed summarize molecular mechanisms through these conditions.

Язык: Английский

Процитировано

1
Caffeine Ameliorates Metabolic-Associated Steatohepatitis by Rescuing Hepatic Dusp9 DOI Creative Commons
Xin Xin, Cheng Chen, Xiaoxue Xu

и другие.

Redox Biology, Год журнала: 2025, Номер 80, С. 103499 - 103499

Опубликована: Янв. 22, 2025

Язык: Английский

Процитировано

1
Hinokitiol ameliorates MASH in mice by therapeutic targeting of hepatic Nrf2 and inhibiting hepatocyte ferroptosis DOI

Xunzhe Yin,

Zuojia Liu, Chang Li

и другие.

Phytomedicine, Год журнала: 2025, Номер 139, С. 156472 - 156472

Опубликована: Фев. 5, 2025

Язык: Английский

Процитировано

1
The emerging role of E3 ubiquitin ligases and deubiquitinases in metabolic dysfunction-associated steatotic liver disease DOI Creative Commons
Yu Zhang, Jiahui Yang, Jiali Min

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Март 25, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic worldwide, with a prevalence as high 32.4%. MASLD encompasses spectrum of pathologies, ranging from steatosis to metabolic steatohepatitis (MASH), fibrosis, and, in some cases, progression end-stage (cirrhosis and hepatocellular carcinoma). A comprehensive understanding pathogenesis this highly prevalent may facilitate identification novel targets for development improved therapies. E3 ubiquitin ligases deubiquitinases (DUBs) are key regulatory components ubiquitin‒proteasome system (UPS), which plays pivotal role maintaining intracellular protein homeostasis. Emerging evidence implicates that aberrant expression DUBs involved MASLD. Here, we review abnormalities by (1) discussing their targets, mechanisms, functions MASLD; (2) summarizing pharmacological interventions targeting these enzymes preclinical clinical studies; (3) addressing challenges future therapeutic strategies. This synthesizes current highlight strategies based on UPS progressive disease.

Язык: Английский

Процитировано

1
Cellular preconditioning and mesenchymal stem cell ferroptosis DOI
Doaa Hussein Zineldeen, Mazhar Mushtaq, Khawaja Husnain Haider

и другие.

World Journal of Stem Cells, Год журнала: 2024, Номер 16(2), С. 64 - 69

Опубликована: Фев. 25, 2024

In this editorial, we comment on the article published in recent issue of

Язык: Английский

Процитировано

5
Insight into the regulatory mechanism of m6A modification: From MAFLD to hepatocellular carcinoma DOI Open Access

Xuan Zha,

Zewei Gao,

Min Li

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 116966 - 116966

Опубликована: Июнь 20, 2024

In recent years, there has been a significant increase in the incidence of metabolic-associated fatty liver disease (MAFLD), which attributed to increasing prevalence type 2 diabetes mellitus (T2DM) and obesity. MAFLD affects more than one-third adults worldwide, making it most prevalent globally. Moreover, is considered risk factor for hepatocellular carcinoma (HCC), with MAFLD-related HCC cases increasing. Approximately 1 6 patients are believed have MAFLD, nearly 40 % these do not progress cirrhosis, indicating direct transformation from HCC. N6-methyladenosine (m

Язык: Английский

Процитировано

3
Liposome preparation of alpha-arbutin: stability and toxicity assessment using mouse B16F10 melanoma cells DOI
Altevir Rossato Viana,

Thatyana Cassol Poleze,

Franciele da Silva Bruckmann

и другие.

Journal of Toxicology and Environmental Health, Год журнала: 2024, Номер 87(22), С. 879 - 894

Опубликована: Сен. 2, 2024

Melanoma is the most aggressive type of skin cancer, with few therapeutic alternatives following metastasis development. In recent years, drug delivery-associated nanotechnology has shown promising targeted results diminished adverse effects compared to conventional treatments. This study aimed (1) examine plant-derived α-arbutin, a natural compound and (2) compare these findings bioactively developed liposomes containing α-arbutin utilizing B16-F10 murine melanoma cell line as model. Liposomes were obtained through reversed-phase evaporation by applying spray dryer assess their stability. The biologic assays measured cytotoxicity/antiproliferative (MTT, Neutral Red, dsDNA PicoGreen). addition, levels melanin purinergic enzymes also measured. production reactive oxygen species (ROS) nitric oxide (NO) was determined measure oxidative state. Treatment nano-liposome alpha-arbutin induced significant 68.4% cytotoxicity, similar positive control, in at 72 hr. Further, arbutin increased ROS nitrite formation hr highest concentration (100 300 µg/ml) Arbutin reduced all tested concentrations. lowered nucleotides (AMP, ADP, ATP) nucleoside (adenosine) cells. Evidence suggests that liposome can be considered an alternative immunosuppressive agent stimulated treatment.

Язык: Английский

Процитировано

3
Nuciferine Alleviates High-Fat Diet- and ApoE–/–-Induced Hepatic Steatosis and Ferroptosis in NAFLD Mice via the PPARα Signaling Pathway DOI
Jiannan Qiu, Yifei Le, Nian Liu

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(44), С. 24417 - 24431

Опубликована: Окт. 24, 2024

Nonalcoholic fatty liver disease (NAFLD) causes significant global mortality and healthcare costs with no recommended pharmacological intervention for clinical management. Nuciferine (Nuc) is an alkaloid aromatic rings, abundantly found in

Язык: Английский

Процитировано

3
Research progress of cysteine transporter SLC7A11 in endocrine and metabolic diseases DOI

Jiaqi Chen,

Ming‐Long Yuan, Jianping Wang

и другие.

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Фев. 3, 2025

Язык: Английский

Процитировано

0
Target discovery-directed pharmacological mechanism elucidation of bioactive natural products DOI Creative Commons
Zhao Zhen,

Lina Yin,

Tingting Niu

и другие.

Medical Review, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Abstract Natural products, the most important chemical library with magical structures and unique functions, have long been playing significant roles in contributing to discovery of novel drugs. The complexity diversity natural products present great challenges regarding exploration their potential targets. Identifying targets not only enhances our understanding biological functions molecular mechanisms, but also paves way for discovering lead compounds disease treatment. Recent advances technologies like biology, structural artificial intelligence provided powerful tools pinpointing product target unraveling mechanisms. This review aims comprehensively summarize innovative strategies employed recent years identify targets, evaluate impact on pathways by modulating pharmacological effects. Moreover, we discuss encountered this field outline future research prospects, aiming offer guidance researchers biology.

Язык: Английский

Процитировано

0