Downregulation of SLC7A11 by Bis(4‐Hydroxy‐3,5‐Dimethylphenyl) Sulfone Induces Ferroptosis in Hepatocellular Carcinoma Cell

Molecular Carcinogenesis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

The progression of tumors has been demonstrated to have a strong correlation with ferroptosis. Bis(4-hydroxy-3,5-dimethylphenyl) sulfone (TMBPS) shown effectively inhibit the proliferation hepatocellular carcinoma (HCC), but its underlying mechanism is not clear. In this study, ferrostatin-1 (Fer-1) was employed explore whether death HCC cells caused by TMBPS related intracellular lipid peroxides, Fe2+, malondialdehyde (MDA), GSH/GSSG, mitochondrial morphology, and potential were detected after treatment. target predicted molecular docking approach verified via quantitative real-time polymerase chain reaction (qRT-PCR), western blot, cellular heat transfer assay (CETSA). Our results revealed that Fer-1 reversed cell induced in cells. Treatment typical ferroptosis features, including increased levels MDA, along decreased GSSH/GSH ratio potential. These effects overexpressing SLC7A11. findings suggest triggered linked ferroptosis, potentially mediated through inhibition SLC7A11 expression.

Language: Английский

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The Role of Solute Carrier Family Transporters in Hepatic Steatosis and Hepatic Fibrosis

Journal of Clinical and Translational Hepatology, Journal Year: 2025, Volume and Issue: 000(000), P. 000 - 000

Published: Jan. 22, 2025

Solute carrier (SLC) family transporters are crucial transmembrane proteins responsible for transporting various molecules, including amino acids, electrolytes, fatty and nucleotides. To date, more than fifty SLC transporter subfamilies have been identified, many of which linked to the progression hepatic steatosis fibrosis. These conditions often caused by factors such as non-alcoholic liver disease steatohepatitis, major contributors global burden. The activity members regulates transport substrates across biological membranes, playing key roles in lipid synthesis metabolism, mitochondrial function, ferroptosis. processes, turn, influence function hepatocytes, stellate cells, macrophages, thereby contributing development Additionally, some involved drug transport, acting critical regulators drug-induced steatosis. Beyond substrate certain also exhibit additional functions. Given pivotal role fibrosis, this review aimed summarize molecular mechanisms through these conditions.

Language: Английский

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Caffeine Ameliorates Metabolic-Associated Steatohepatitis by Rescuing Hepatic Dusp9

Redox Biology, Journal Year: 2025, Volume and Issue: 80, P. 103499 - 103499

Published: Jan. 22, 2025

Language: Английский

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Hinokitiol ameliorates MASH in mice by therapeutic targeting of hepatic Nrf2 and inhibiting hepatocyte ferroptosis

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156472 - 156472

Published: Feb. 5, 2025

Language: Английский

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Mesenchymal stem cell-derived extracellular vesicles attenuate ferroptosis in aged hepatic ischemia/reperfusion injury by transferring miR-1275

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103556 - 103556

Published: Feb. 18, 2025

Language: Английский

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RNA Modification in Metabolism

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

ABSTRACT Epigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and most prevalent modification N6‐methyladenosine (m 6 A). Recently, emerged as a potential target for treatment. posttranscriptional gene expression that involved both physiological pathological processes. Evidence suggests m A significantly affects metabolism, its abnormal changes have observed variety diseases. Metabolic diseases are series caused by metabolic processes body, common include diabetes mellitus, obesity, nonalcoholic fatty liver disease, etc.; although pathogenesis these differs from each other to current understanding, recent studies suggested pivotal role modulating diseases, A‐based drug on agenda. This paper reviewed understanding hoping provide systematic information those area.

Language: Английский

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Ferroptosis in Endometriosis: Traditional Chinese Medicine Interventions and Mechanistic Insights

The American Journal of Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 27, 2025

Endometriosis (EMS) is a chronic, estrogen-dependent inflammatory disease affecting 5–10% of women reproductive age, characterized by the growth endometrial tissue on outside uterus. The dysregulation iron metabolism leads to accumulation ions at lesion sites, resulting in oxidative stress and pro-inflammatory responses that promote progression EMS. mechanisms underlying ferroptosis EMS primarily involve accumulation, lipid peroxidation, loss glutathione peroxidase 4 activity. These confer resistance within ectopic tissues facilitate cell survival proliferation. Traditional Chinese medicine (TCM) has demonstrated therapeutic potential for modulating ferroptosis. Studies have shown TCM monomers may regulate transport proteins anti-oxidant defense mechanisms. formulas employ distinct treatment strategies depending stage EMS: early stages, they control growth, whereas later inhibit reduce inflammation order improve health slow progression. This study provides new perspective management summarizing role its pathological reviewing findings use regulating

Language: Английский

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Liposome preparation of alpha-arbutin: stability and toxicity assessment using mouse B16F10 melanoma cells

Journal of Toxicology and Environmental Health, Journal Year: 2024, Volume and Issue: 87(22), P. 879 - 894

Published: Sept. 2, 2024

Melanoma is the most aggressive type of skin cancer, with few therapeutic alternatives following metastasis development. In recent years, drug delivery-associated nanotechnology has shown promising targeted results diminished adverse effects compared to conventional treatments. This study aimed (1) examine plant-derived α-arbutin, a natural compound and (2) compare these findings bioactively developed liposomes containing α-arbutin utilizing B16-F10 murine melanoma cell line as model. Liposomes were obtained through reversed-phase evaporation by applying spray dryer assess their stability. The biologic assays measured cytotoxicity/antiproliferative (MTT, Neutral Red, dsDNA PicoGreen). addition, levels melanin purinergic enzymes also measured. production reactive oxygen species (ROS) nitric oxide (NO) was determined measure oxidative state. Treatment nano-liposome alpha-arbutin induced significant 68.4% cytotoxicity, similar positive control, in at 72 hr. Further, arbutin increased ROS nitrite formation hr highest concentration (100 300 µg/ml) Arbutin reduced all tested concentrations. lowered nucleotides (AMP, ADP, ATP) nucleoside (adenosine) cells. Evidence suggests that liposome can be considered an alternative immunosuppressive agent stimulated treatment.

Language: Английский

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Nuciferine Alleviates High-Fat Diet- and ApoE^–/–-Induced Hepatic Steatosis and Ferroptosis in NAFLD Mice via the PPARα Signaling Pathway

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(44), P. 24417 - 24431

Published: Oct. 24, 2024

Nonalcoholic fatty liver disease (NAFLD) causes significant global mortality and healthcare costs with no recommended pharmacological intervention for clinical management. Nuciferine (Nuc) is an alkaloid aromatic rings, abundantly found in

Language: Английский

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Research progress of cysteine transporter SLC7A11 in endocrine and metabolic diseases

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 3, 2025

Language: Английский

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