Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
The
emerged
apoptosis/ferroptosis
synergistic
platinum-based
therapy
has
attracted
a
lot
of
attention
but
is
far
from
clinic
use
due
to
high
systemic
toxicity.
Herein,
series
novel
precise
carrier-free
self-assembled
platinum(IV)
nanoparticles
with
lipid
regulation
effect
named
FSPNPs
(5NPs–8NPs)
were
constructed
via
connecting
fenofibrate
acid
(FA)
cisplatin
or
oxaliplatin-derived
platinum(IV)-intermediates
disulfide
bonds.
can
be
stimulated
by
high-glutathione/ascorbic
and
acidity
environment
produce
an
"explosion-like"
cascade
release
process.
Cell-activity
showed
precision
FSPNPs,
which
accumulated
more
in
tumor
cells
inhibited
cell
proliferation.
Especially,
5NPs
have
higher
selectivity
than
cisplatin.
downregulated
glutathione/glutathione
peroxidase
4,
increased
reactive
oxygen
species/lipid
peroxidation/malondialdehyde,
induced
DNA
damage/S-phase
arrest,
regulated
p53/Bcl-2/Bax
trigger
the
hybrid
pathway.
released
FA
derivates
docked
into
peroxisome
proliferator-activated
receptor
α
activating
cholesterol
metabolism
destroy
membrane
integrity.
also
good
biocompatibility
superior
antitumor
activity
no
observable
tissue
damage.
Heliyon,
Год журнала:
2024,
Номер
10(18), С. e37613 - e37613
Опубликована: Сен. 1, 2024
Oxaliplatin
(OXA)-based
therapy
is
effective
in
the
treatment
of
multiple
cancers.
However,
primary
or
acquired
OXA
resistance
remains
an
emerging
challenge
for
its
clinical
application.
Ferroptosis
iron-dependent
mode
cell
death
that
has
been
demonstrated
to
play
essential
role
chemoresistance
many
drugs,
including
OXA.
In
particular,
dysregulation
SLC7A11-GPX4,
one
major
antioxidant
systems
ferroptosis,
was
found
colorectal
cancer
(CRC)
and
hepatocellular
carcinoma
(HCC).
addition,
Nrf2,
upstream
regulator
GPX4
other
factors,
also
involved
CRC
HCC.
Inhibition
SLC7A11-GPX4
Nrf2
by
genetic
deletion
pharmaceutical
inhibition
could
significantly
reverse
resistance.
Long
noncoding
RNA
(lncRNA)
participates
ferroptosis
cells.
Specifically,
LINC01134
promotes
recruitment
promoter
GPX4,
thereby
exerting
transcriptional
regulation
which
eventually
increases
sensitivity
HCC
through
upregulation
ferroptosis.
On
hand,
a
novel
lncRNA
DACT3-AS1
sensitizes
gastric
cells
miR-181a-5p/sirtuin
1(SIRT1)-mediated
Therapies
based
on
combination
enhancers
provide
new
therapeutic
insights
overcome
present
review,
we
current
understanding
ferroptosis-related
resistance,
highlight
pathogenesis
chemoresistance,
summarize
available
therapies
target
enhancing
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 22, 2024
The
identification
of
ferroptosis
represents
a
pivotal
advancement
in
the
field
cell
death
research,
revealing
an
entirely
novel
mechanism
cellular
demise
and
offering
new
insights
into
initiation,
progression,
therapeutic
management
various
diseases.
Ferroptosis
is
predominantly
induced
by
intracellular
iron
accumulation,
lipid
peroxidation,
or
impairments
antioxidant
defense
system,
culminating
membrane
rupture
consequent
death.
Studies
have
associated
with
wide
range
diseases,
enhancing
our
comprehension
its
underlying
mechanisms,
we
can
formulate
innovative
strategies,
thereby
providing
renewed
hope
for
patients.
Journal of Applied Toxicology,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 18, 2024
Abstract
Doxorubicin
(DOX)
is
a
chemotherapy
drug
widely
used
in
clinical
settings,
acting
as
first‐line
treatment
for
various
malignant
tumors.
However,
its
use
greatly
limited
by
the
cardiotoxicity
it
induces,
including
doxorubicin‐induced
cardiomyopathy
(DIC).
The
mechanisms
behind
DIC
are
not
fully
understood,
but
potential
biological
thought
to
include
oxidative
stress,
inflammation,
energy
metabolism
disorders,
mitochondrial
damage,
autophagy,
apoptosis,
and
ferroptosis.
Recent
studies
have
shown
that
cardiac
injury
induced
DOX
closely
related
Due
their
high
efficacy,
availability,
low
side
effects,
natural
medicine
treatments
hold
strong
potential.
Currently,
medicines
been
mitigate
DOX‐induced
ferroptosis
ease
through
functions
such
antioxidation,
iron
ion
homeostasis
correction,
lipid
regulation,
function
improvement.
Therefore,
this
review
summarizes
of
regulation
plant
products,
with
expectation
providing
reference
future
research
development
inhibitors
targeting
DIC.
This
explores
(DIC)
how
products
can
alleviate
inhibiting
reducing
correcting
homeostasis,
regulating
metabolism,
improving
function.
Pain and Therapy,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Pain,
a
complex
symptom
encompassing
both
sensory
and
emotional
dimensions,
constitutes
significant
global
public
health
issue.
Oxidative
stress
is
pivotal
factor
in
the
pathophysiology
of
pain,
with
glutathione
peroxidase
4
(GPX4)
recognized
as
crucial
antioxidant
enzyme
involved
defense
mechanisms
ferroptosis
pathways.
This
review
systematically
explores
GPX4's
functions
across
various
pain
models,
including
neuropathic,
inflammatory,
low
back,
cancer-related
pain.
Specifically,
focus
includes
physiological
roles,
mechanisms,
regulation
ferroptosis,
involvement
signal
transduction
pathways,
metabolic
regulation.
By
summarizing
current
research,
we
highlight
potential
GPX4-targeted
therapies
management.
Advances in medical technologies and clinical practice book series,
Год журнала:
2024,
Номер
unknown, С. 79 - 134
Опубликована: Сен. 14, 2024
The
field
of
toxicology
is
undergoing
a
significant
transformation
due
to
the
integration
artificial
intelligence
(AI).
In
addition
traditional
reliance
on
empirical
studies
and
animal
testing,
AI-powered
predictive
now
used
predict
toxic
effects
chemicals
drugs.
This
chapter
examines
role
AI
in
enhancing
accuracy,
efficiency,
breadth
toxicological
assessments
by
bridging
gap
between
approaches
advanced
techniques.
It
explores
various
methodologies,
such
as
machine
learning,
deep
neural
networks,
focusing
their
application
toxicity
prediction.
Furthermore,
this
investigates
with
databases
development
validation
models.
also
addresses
challenges
associated
toxicology,
including
data
quality,
model
interpretability,
scalability.
concludes
that
despite
facing
challenges,
powerful
tool
modern
analysis.
