Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 2485 - 2529

Опубликована: Июнь 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Язык: Английский

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MG53 inhibits ferroptosis by targeting the p53/SLC7A11/GPX4 pathway to alleviate doxorubicin-induced cardiotoxicity

Free Radical Biology and Medicine, Год журнала: 2024, Номер 223, С. 224 - 236

Опубликована: Авг. 6, 2024

Язык: Английский

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Punicalagin inhibits neuron ferroptosis and secondary neuroinflammation to promote spinal cord injury recovery

International Immunopharmacology, Год журнала: 2025, Номер 148, С. 114048 - 114048

Опубликована: Янв. 18, 2025

Язык: Английский

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Hollow mesoporous prussian blue nanozymes alleviate doxorubicin-induced cardiotoxicity by restraining oxidative stress associated with Nrf2 signaling

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 686, С. 1074 - 1088

Опубликована: Фев. 6, 2025

Язык: Английский

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The anti-Alzheimer's Disease effects of ganoderic acid A by inhibiting ferroptosis-lipid peroxidation via activation of the NRF2/SLC7A11/GPX4 signaling pathway

Chemico-Biological Interactions, Год журнала: 2025, Номер 412, С. 111459 - 111459

Опубликована: Март 5, 2025

Язык: Английский

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ROS-mediated ferroptosis and pyroptosis in cardiomyocytes: An update

Life Sciences, Год журнала: 2025, Номер unknown, С. 123565 - 123565

Опубликована: Март 1, 2025

Язык: Английский

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Synchronously Evoking Disulfidptosis and Ferroptosis via Systematical Glucose Deprivation Targeting SLC7A11/GSH/GPX4 Antioxidant Axis

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Disulfidptosis and ferroptosis are recently identified programmed cell deaths for tumor therapy, both of which highly depend on the intracellular cystine/cysteine transformation cystine transporter solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 (SLC7A11/GSH/GPX4) antioxidant axis. However, disulfidptosis usually asynchronous due to opposite effect transport them. Herein, systematic glucose deprivation, by inhibiting upstream uptake promoting downstream consumption, is proposed synchronously evoke ferroptosis. As an example, Au nanodots Fe-apigenin (Ap) complexes coloaded FeOOH nanoshuttles (FeOOH@Fe-Ap@Au NSs) employed regulate SLC7A11/GSH/GPX4 axis performing disulfidptosis- ferroptosis-mediated therapy synchronously. In this scenario, exhibit oxidase-like activity when consuming massive glucose. Meanwhile, Ap can inhibit downregulating 1, depriving fundamentally. The systematical deprivation limits supplement NADPH suppresses axis, thus solving contradiction addition, efficient delivery exogenous iron ions FeOOH@Fe-Ap@Au NSs self-supplied H2O2 through nanodots-catalytic oxidation facilitate Fenton reaction therewith help amplify a result synchronous occurrence ferroptosis, good efficacy in ovarian cancer therapeutic model.

Язык: Английский

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MAPK14 drives Ferroptosis and immune dysfunction in pediatric Sepsis-induced acute lung injury

Cellular Immunology, Год журнала: 2025, Номер unknown, С. 104948 - 104948

Опубликована: Апрель 1, 2025

Язык: Английский

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Galangin alleviated Doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through GSTP1/JNK pathway

Phytomedicine, Год журнала: 2024, Номер 134, С. 155989 - 155989

Опубликована: Авг. 31, 2024

Язык: Английский

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Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles alleviates atherosclerosis by suppressing macrophage ferroptosis via the NRF2/SLC7A11/GPX4 pathway.

Archives of Biochemistry and Biophysics, Год журнала: 2025, Номер 765, С. 110316 - 110316

Опубликована: Янв. 22, 2025

Язык: Английский

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