Biomaterials Science, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Nanocomposite hydrogels offer a promising approach to treating diabetic wounds. Key findings include enhanced mechanical properties, antibacterial effects, and the ability regulate wound microenvironment.
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155575 - 155575
Опубликована: Сен. 7, 2024
Язык: Английский
Процитировано
8
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 11321 - 11341
Опубликована: Ноя. 1, 2024
Background: Conventional wound dressings often adhere to wounds and can cause secondary injury due their lack of anti-inflammatory antibacterial properties. In contrast, collagen-based nanoparticles (NPs) as drug delivery systems exhibit both biocompatibility biodegradability, presenting a promising avenue for accelerating healing processes. Aims Study: This review aims provide comprehensive overview the mechanisms involved in healing, description attributes ideal dressings, understanding efficacy collagen, exploring NPs-mediated therapy, detailing synthesis fabrication techniques NPs, delineating applications various NPs infused on healing. Methodology: synthesizes relevant literature from reputable databases such Scopus, Science Direct, Google Scholar, PubMed. Results: A diverse array including nanopolymers, metal nanoemulsions, nanoliposomes, nanofibers, demonstrate pronounced promoting closure tissue regeneration. The incorporation has not only become an agent therapeutics but also actively contributes cascade. Conclusion: conclusion, brief, use presents compelling strategy expediting Keywords: nanoparticles, techniques, collagen
Язык: Английский
Процитировано
5
Journal of Biomaterials Science Polymer Edition, Год журнала: 2025, Номер unknown, С. 1 - 14
Опубликована: Янв. 6, 2025
The risks associated with wound infections are significant, making a snug-fitting hydrogel dressing an optimal choice for management. For it, we employed the self-cross-linking method of oxidized sodium alginate (SCSA), incorporating clarithromycin (Cla) and basic fibroblast growth factor (bFGF) to formulate rapidly forming, bacteriostatic, wound-healing (SCSA@C/b). Bacteriostatic cytocompatibility assays demonstrated that SCSA@C/b exhibits exceptional antibacterial activity alongside strong biocompatibility. A fractional infected model showed accelerated healing wounds by approximately three days compared time control group, nearly complete recovery. H&E staining SEM analysis healed sections revealed significant pro-healing effects. Thus, is promising medicinal encouraging in contaminated areas.
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 430 - 430
Опубликована: Март 18, 2025
Collagen is the main protein found in skin, bone, cartilage, ligaments, tendons and connective tissue, it can exhibit properties ranging from compliant to rigid or form gradients between these states. The collagen family comprises 28 members, each containing at least one triple-helical domain. These proteins play critical roles maintaining mechanical characteristics, tissue organization, structural integrity. Collagens regulate cellular processes such as proliferation, migration, differentiation through interactions with cell surface receptors. Fibrillar collagens, most abundant extracellular matrix (ECM) proteins, provide organs tissues stability connectivity. In mammalian myocardial interstitium, types I III collagens are predominant: organs, tendons, bones; II cartilage; reticular fibers; IV basement membranes; V nails hair. Recombinant human particularly sponge-like porous formats combined bone morphogenetic serve effective scaffolds for repair. Due their biocompatibility low immunogenicity, pivotal engineering applications wound regeneration. technology enables production of amino acid sequences identical tissue-derived collagens. This review summarizes recent advances molecular functions recombinant expression a focus on biomedical applications.
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 17, 2024
Язык: Английский
Процитировано
3
Biomaterials Science, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Natural resource based polymers, especially those derived from proteins, have attracted significant attention for their potential utilization in advanced wound care applications. Protein materials provide superior biocompatibility, biodegradability, and other functionalities compared to conventional dressings. The effectiveness of various fabrication techniques, such as electrospinning, phase separation, self-assembly, ball milling, is examined the context developing protein-based healing. These methods produce a wide range forms, including hydrogels, scaffolds, sponges, films, bioinspired nanomaterials, each designed specific types wounds different stages This review presents comprehensive analysis recent research that investigates transformation proteins into healing Our focus on essential keratin, collagen, gelatin, silk, zein, albumin, we emphasize distinct traits roles management. Protein-based show promising biomedical engineering, offering improved capabilities reduced risks infection. It crucial explore use these clinical settings while also addressing challenges may arise commercialization future.
Язык: Английский
Процитировано
2
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Авг. 12, 2024
Tympanic membrane perforation (TMP) is one of the most common conditions in otolaryngology worldwide, and hearing damage caused by inadequate or prolonged healing can be distressing for patients. This article examines rationale utilizing three-dimensional (3D) printing to produce scaffolds repairing TMP, compares advantages disadvantages 3D printed bioprinted grafts with traditional autologous materials other tissue engineering TMP repair, highlights practical clinical significance repair while discussing current progress promising future bioprinting. There a limited number reviews specifically dedicated repair. The majority offer general overview applications broader realm regeneration, some mention Alternatively, they explore biopolymers, cells, drug molecules utilized However, more in-depth analysis needed on strategies selecting bio-inks that integrate tympanic
Язык: Английский
Процитировано
1
Separations, Год журнала: 2024, Номер 11(12), С. 339 - 339
Опубликована: Ноя. 26, 2024
The purpose of this study is to achieve the quantitative detection recombinant type III collagen (rh-COL-III) in dressings with complex matrix. First all, marker peptide (GEAGIPGVPGAK) rhCOL-III was identified HPLC-MS/MS. Then, a qualitative and method based on peptides established validated. In order obtain higher sensitivity, pretreatment liquid, gel, ointment optimized. reference material for quantification combined using blank matrix each dressing. results indicated that relative standard deviation (RSD) 2.77%, RSD intraday interday precision 2.76% 2.31%, respectively. spiking recovery rate between 80% 90%. optimal Tris-HCl solvent replacement. trypsin concentration dressing solution 20 μg 500 μL. preparing substances can effectively eliminate influence effect results. average rates 50 μg/mL, 100 200 μg/mL three different ranged from 120%. limit (LOD) 1 ng/mL, 2 ng/g, ng/g ointment, gel dressings.
Язык: Английский
Процитировано
0
Biomaterials Science, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Nanocomposite hydrogels offer a promising approach to treating diabetic wounds. Key findings include enhanced mechanical properties, antibacterial effects, and the ability regulate wound microenvironment.
Язык: Английский
Процитировано
0